Scientific Reports, 2017 The RNA-binding protein Musashi-1 (MSI1) exerts essential roles in multiple cellular functions, such as maintenance of self-renewal and pluripotency of stem cells.
Hsiao-Yun Chen +12 more
doaj +1 more source
The AKT inhibitor triciribine in combination with paclitaxel has order-specific efficacy against Zfp217-induced breast cancer chemoresistance [PDF]
, 2017 We previously identified the transcription factor ZNF217 (human) / Zfp217 (mouse) as an oncogene and prognostic indicator of reduced survival, increased metastasis, and reduced response to therapy in breast cancer patients.
Badve, Sunil S. +5 more
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Comparative Analysis of the Frequency and Distribution of Stem and Progenitor Cells in the Adult Mouse Brain [PDF]
cells (NSCs) and progenitor cells, but it cannot discriminate between these two populations. Given two assays have purported to overcome this shortfall, we performed a comparative analysis of the distribution and frequency of NSCs and progenitor ...
Aguirre +64 more
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Musashi1 as a potential therapeutic target and diagnostic marker for lung cancer
Oncotarget, 2013 Lung cancer remains one of the leading causes of cancer-related deaths worldwide with a 5-year survival rate of less than 20%. One approach to improving survival is the identification of biomarkers to detect early stage disease. In this study, we investigated the potential of the stem cell and progenitor cell marker, Musashi1 (Msi1), as a diagnostic ...
Xiao-Yang, Wang +8 more
openaire +3 more sources
Cellular Physiology and Biochemistry, 2017 Background/Aims: Lung cancer is one of the leading causes for cancer mortality. The poor therapeutic outcome of non-small cell lung carcinoma (NSCLC) is mainly due to late diagnosis and chemoresistance. In this study, we investigated the role of Musashi1
Yaoguo Lang +8 more
doaj +1 more source
Neurogenesis in zebrafish – from embryo to adult [PDF]
, 2013 Neurogenesis in the developing central nervous system consists of the induction and proliferation of neural progenitor cells and their subsequent differentiation into mature neurons. External as well as internal cues orchestrate neurogenesis in a precise
Rebecca Schmidt +2 more
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Musashi-1 promotes a cancer stem cell lineage and chemoresistance in colorectal cancer cells
Scientific Reports, 2017 Colorectal cancers (CRCs) are a critical health issue worldwide. Cancer stem cell (CSC) lineages are associated with tumour transformation, progression, and malignant transformation.
Guang-Yuh Chiou +9 more
doaj +1 more source
Genomic Analyses of Musashi1 Downstream Targets Show a Strong Association with Cancer-related Processes [PDF]
Journal of Biological Chemistry, 2009 Musashi1 (Msi1) is a highly conserved RNA-binding protein with pivotal functions in stem cell maintenance, nervous system development, and tumorigenesis. Despite its importance, only three direct mRNA targets have been characterized so far: m-numb, CDKN1A, and c-mos.
Raquel, de Sousa Abreu +10 more
openaire +2 more sources
Musashi-1 is the candidate of the regulator of hair cell progenitors during inner ear regeneration
BMC Neuroscience, 2017 Background Hair cell loss in the cochlea is caused by ototoxic drugs, aging, and environmental stresses and could potentially lead to devastating pathophysiological effects.
Takahiro Wakasaki +7 more
doaj +1 more source
Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention [PDF]
, 2014 Glycogen synthase kinase-3 (GSK-3) is well documented to participate in a complex array of critical cellular processes. It was initially identified in rat skeletal muscle as a serine/threonine kinase that phosphorylated and inactivated glycogen synthase.
A Ballin +154 more
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