Results 51 to 60 of about 2,567 (167)

Arabidopsis TRB Proteins Form Two Closely Related Complexes to Mediate H3K4me3 Demethylation and Transcriptional Repression

Advanced Science, Volume 12, Issue 47, December 18, 2025.
This study reveals that Arabidopsis telomere repeat binding proteins (TRBs) form two closely related complexes. These complexes mediate H3K4me3 demethylation and transcriptional repression through a positive feedback loop and cooperate with PEAT and PRC2 complexes to regulate multiple histone modifications and gene expression across the genome ...
Qi Wang, Dan‐Yang Yuan, Yu‐Jia Lu, Xin Wang, Hao Zheng, Lin Li, She Chen, Xin‐Jian He   +7 more
wiley   +1 more source

Regulation of miRNAs by Agents Targeting the Tumor Stem Cell Markers DCLK1, MSI1, LGR5, and BMI1 [PDF]

Current Pharmacology Reports, 2015
Gastrointestinal cancers such as colorectal, pancreatic, liver, gastric, and esophageal, are the most common forms of malignant cancers. MicroRNAs (miRNA) play important role in regulating gastrointestinal cancer progress either as potent oncogenes or tumor suppressors.
Sripathi M, Sureban, Dongfeng, Qu, Courtney W, Houchen   +2 more
openaire   +2 more sources

Cancer Stem Cells in Human Gastrointestinal and Hepatic Cancers

MedComm, Volume 6, Issue 12, December 2025.
Gastrointestinal cancer stem cells obtain the ability of unlimited self‐renewal, drug resistance, tumorigenicity as well as tendency of metastasis. ABSTRACT Gastrointestinal cancers, including gastric, hepatic, and colorectal cancers, represent a major public health problem globally. Although the 5‐year survival rate of gastrointestinal tumors has been
Jiawen Bu, Mingming Cui, Yu Zhang, Yu Lu, Xudong Zhu, Fu Peng, Hong Zhang   +6 more
wiley   +1 more source

The Musashi family RNA-binding proteins in stem cells

Biomolecular Concepts, 2010
The Musashi family is an evolutionarily conserved group of RNA-binding proteins. In mammal, two members of the group, Msi1 and Msi2, have been identified to date.
Horisawa Kenichi, Imai Takao, Okano Hideyuki, Yanagawa Hiroshi   +3 more
doaj   +1 more source

Structural Insight into the Recognition of r(UAG) by Musashi-1 RBD2, and Construction of a Model of Musashi-1 RBD1-2 Bound to the Minimum Target RNA

Molecules, 2017
Musashi-1 (Msi1) controls the maintenance of stem cells and tumorigenesis through binding to its target mRNAs and subsequent translational regulation.
Ryo Iwaoka, Takashi Nagata, Kengo Tsuda, Takao Imai, Hideyuki Okano, Naohiro Kobayashi, Masato Katahira   +6 more
doaj   +1 more source

MicroRNA156‐SPL13B Module Induces Parthenocarpy Through the Gibberellin Pathway

Plant Biotechnology Journal, Volume 23, Issue 12, Page 5536-5549, December 2025.
ABSTRACT Fruit development typically follows pollination and fertilisation. However, parthenocarpy, the formation of seedless fruits, represents an alternative pathway. The fruit that grows from the ovary under unpollinated and/or unfertilised conditions is termed parthenocarpic.
Da‐Ru Wang, Chun‐Ling Zhang, Xun Wang, Dan‐Dan Liu, Xin Liu, Guo‐Lin Chen, Qing Wang, Man‐Shu Qu, Kuo Yang, Chun‐Xiang You, Xiao‐Fei Wang   +10 more
wiley   +1 more source

Musashi-1 promotes cancer stem cell properties of glioblastoma cells via upregulation of YTHDF1

Cancer Cell International, 2020
Background Glioblastoma (GBM) is the most lethal brain tumor characterized by high morbidity and limited treatment options. Tumor malignancy is usually associated with the epigenetic marks, which coordinate gene expression to ascertain relevant ...
Aliaksandr A. Yarmishyn, Yi-Ping Yang, Kai-Hsi Lu, Yi-Chen Chen, Yueh Chien, Shih-Jie Chou, Ping-Hsing Tsai, Hsin-I. Ma, Chian-Shiu Chien, Ming-Teh Chen, Mong-Lien Wang   +10 more
doaj   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, Volume 19, Issue 11, Page 3135-3155, November 2025.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

PcG Proteins MSI1 and BMI1 Function Upstream of miR156 to Regulate Aerial Tuber Formation in Potato [PDF]

Plant Physiology, 2019
Polycomb Repressive Complexes (PRC1 and PRC2) regulate developmental transitions in plants. AtBMI1, a PRC1 member, represses micro RNA156 (miR156) to trigger the onset of adult phase in Arabidopsis (Arabidopsis thaliana). miR156 overexpression (OE) reduces below-ground tuber yield, but stimulates aerial tubers in potato (Solanum tuberosum ssp andigena)
Amit Kumar, Kirtikumar Ramesh Kondhare, Pallavi Vijay Vetal, Anjan Kumar Banerjee   +3 more
openaire   +2 more sources

Exosomal circ_IFT80 Enhances Tumorigenesis and Suppresses Radiosensitivity in Colorectal Cancer by Regulating miR-296-5p/MSI1 Axis

Cancer Management and Research, 2021
Liang Li,1 Zhipeng Jiang,2 Xiangcai Zou,3 Tengfei Hao1 1Department of Digestive Medicine Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, People’s Republic of China; 2Department of Gastrointestinal Surgery, The Sixth ...
Li L, Jiang Z, Zou X, Hao T
doaj