Results 61 to 70 of about 2,567 (167)

Alteration of Musashi1 Intra-cellular Distribution During Regeneration Following Gentamicin-Induced Hair Cell Loss in the Guinea Pig Crista Ampullaris

Frontiers in Cellular Neuroscience, 2019
The mechanism underlying hair cell (HC) regeneration in the mammalian inner ear is still under debate. Understanding what molecules regulate the HC regeneration in mature mammals will be the key to the treatment of the inner ear disorder. Musashi1 (MSI1)
Makoto Kinoshita, Chisato Fujimoto, Shinichi Iwasaki, Akinori Kashio, Yayoi S. Kikkawa, Kenji Kondo, Hideyuki Okano, Tatsuya Yamasoba   +7 more
doaj   +1 more source

A novel dual epigenetic approach targeting BET proteins and HDACs in Group 3 (MYC-driven) Medulloblastoma

Journal of Experimental & Clinical Cancer Research, 2022
Background Medulloblastoma (MB) patients with MYC oncogene amplification or overexpression exhibit extremely poor clinical outcomes and respond poorly to current therapies. Epigenetic deregulation is very common in MYC-driven MB.
Matthew J. Kling, Varun Kesherwani, Nitish K. Mishra, Gracey Alexander, Erin M. McIntyre, Sutapa Ray, Kishore B. Challagundla, Shantaram S. Joshi, Don W. Coulter, Nagendra K. Chaturvedi   +9 more
doaj   +1 more source

Synthesized Depside Molecules Suppress the Progression of Colorectal Cancer by Binding VDAC1/PHB/MMP9 Being at the Crossroads of Stemness, Motility, Apoptosis, and Metabolism

MedComm, Volume 6, Issue 11, November 2025.
This study suggests that newly synthesized depside compounds suppress the progression of colorectal cancer by directly targeting VDAC1/PHB/MMP9. Especially, SB4 demonstrated significant bioavailability and successfully suppressed the tumor growth. ABSTRACT Lichen secondary metabolites have shown potential in cancer therapy, but strategies to enhance ...
Mücahit Varlı, Young Hyun Yu, Jieun Yu, Suresh R. Bhosle, Sang Kyum Kim, Yoon Gyoon Kim, Hyung‐Ho Ha, Hangun Kim   +7 more
wiley   +1 more source

Downregulation of Msi1 suppresses the growth of human colon cancer by targeting p21cip1

International Journal of Oncology, 2014
Musashi1 (Msi1), a member of the RNA-binding protein (RBP) family, is highly expressed in neural progenitor or stem cells for the maintenance of stemness as well as in various cancers. Emerging studies have demonstrated that it regulates cell processes by translational activation or suppresses specifically bound mRNA. In the present study, we initially
Chao, Gao, Chun, Han, Qiyao, Yu, Yue, Guan, Na, Li, Jingjing, Zhou, Yanming, Tian, Yi, Zhang   +7 more
openaire   +3 more sources

A role for the ELAV RNA-binding proteins in neural stem cells: stabilization ofMsi1mRNA [PDF]

Journal of Cell Science, 2006
Post-transcriptional regulation exerted by neural-specific RNA-binding proteins plays a pivotal role in the development and maintenance of the nervous system. Neural ELAV proteins are key inducers of neuronal differentiation through the stabilization and/or translational enhancement of target transcripts bearing the AU-rich elements (AREs), whereas ...
A. Ratti, C. Fallini, L. Cova, R. Fantozzi, C. Calzarossa, E. Zennaro, A. Pascale, A. Quattrone, V. Silani   +8 more
openaire   +2 more sources

Aging Reduces Intestinal Stem Cell Activity in Killifish and Intermittent Fasting Reverses Intestinal Gene Expression Patterns

Aging Cell, Volume 24, Issue 11, November 2025.
Intestinal stem cells occur in clusters, and the cycle time of stem cells increases with age. The age‐dependent decline in structural intestinal tissue homeostasis is associated with a decline in stem cell activity. Aging causes significant changes in intestinal gene expression; intermittent fasting from adulthood onwards results in a gene expression ...
Michael Kothmayer, Sylvia Laffer, Philipp Widmayer, Elmar E. Ebner, Fehima Ugarak, David Martin, Stefan H. Geyer, Kareem Elsayad, Wolfgang J. Weninger, Sabine Lagger, Klara Weipoltshammer, Oliver Pusch, Christian Schöfer   +12 more
wiley   +1 more source

A critical role for MSI1 and MSI2 in photoreceptor morphogenesis

, 2020
ABSTRACT We previously proposed a role for the Musashi proteins, MSI1 and MSI2, in photoreceptor cell development that is mediated by their ability to control alternative splicing. Photoreceptors with simultaneous deletion of Msi1 and Msi2 did not respond to light, displayed severely disrupted OS morphology and axonemal defects. At postnatal day 5, we
Sundar, Jesse, Matalkah, Fatimah, Jeong, Bohye, Stoilov, Peter, Ramamurthy, Visvanathan   +4 more
openaire   +1 more source

Micropollutants and Their Interactions With Relevant Environmental Viruses

Environmental Microbiology, Volume 27, Issue 10, October 2025.
Environmental micropollutants increase virus stability. ABSTRACT Emerging pollutants encompass a diverse array of chemicals classified as micropollutants, including pharmaceuticals and microplastics (MPs). Viruses are known to adsorb onto MPs, including binding to bacterial biofilms that form the plastisphere.
Catielen Paula Pavi, Mariana Alves Elois, Yasmin Ferreira Souza Hoffmann Jempierre, Rafael Dorighello Cadamuro, Beatriz Pereira Savi, Giulia Von Tönnemann Pilati, Gislaine Fongaro   +6 more
wiley   +1 more source

Aging Adipose‐Derived Mesenchymal Stem Cells, Cultured on a Native Young Extracellular Matrix, Are Protected From Senescence and Apoptosis Along With Increased Expression of HLA‐DR and CD74 Associated With PI3K Signaling

Aging Cell, Volume 24, Issue 9, September 2025.
The maintenance of aging mesenchymal stem cells (MSCs) on extracellular matrix synthesized by human amniotic fluid‐derived pluripotent stem cells (ECM Plus), a young microenvironment, remarkably restored their quantity and quality along with up‐regulating HLA‐DR and CD74.
Aaron O. Gonzalez, Parveez A. Abdul Azees, Jerry P. Chen, Milos Marinkovic, Brian Cao, Ting Liang, Peiqing Hu, Chih‐Ko Yeh, David D. Dean, Yidong Bai, Xiao‐Dong Chen   +10 more
wiley   +1 more source

The WD40 Domain Protein MSI1 Functions in a Histone Deacetylase Complex to Fine-Tune Abscisic Acid Signaling [PDF]

The Plant Cell, 2015
MSI1 belongs to a family of histone binding WD40-repeat proteins. Arabidopsis thaliana contains five genes encoding MSI1-like proteins, but their functions in diverse chromatin-associated complexes are poorly understood. Here, we show that MSI1 is part of a histone deacetylase complex.
Saher Mehdi, Maria Derkacheva, Margareta Ramström, Lejon Kralemann, Jonas Bergquist, Lars Hennig   +5 more
openaire   +4 more sources