Results 71 to 80 of about 2,567 (167)
Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins
BMC Cancer, 2018 Background The Musashi (MSI) family of RNA-binding proteins is best known for the role in post-transcriptional regulation of target mRNAs. Elevated MSI1 levels in a variety of human cancer are associated with up-regulation of Notch/Wnt signaling.
Lan Lan +16 more
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The FASEB Journal, Volume 39, Issue 16, 31 August 2025.Human induced pluripotent stem cells were differentiated into neural stem cells and floor plate progenitors of dopaminergic neurons, followed by microRNA profiling. While intracellular differences were limited, extracellular vesicle microRNAs showed 27 differentially expressed microRNAs and five consistently enriched across lineages.
Lilian Cruz +10 more
wiley +1 more source
PS1017 MICRO RNA SIGNATURE OF ONCOGENIC MUSASHI RNA BINDING PROTEINS MSI1 AND MSI2
HemaSphere, 2019 Background:MSI1 and MSI2 are two paralogous RNA binding proteins (RBPs) which are frequently dysregulated in multiple cancers ranging from breast cancer, gliomas, medullobalstoma to acute myeloid leukemia (AML) and chronic myeloid leukemia (CML). RBPs along with MicroRNAs are key form of regulatory molecules working post‐transcriptionally.
S. Duggimpudi, J. Höll, A. Borkhardt
openaire +1 more source
Allosteric inhibition of a stem cell RNA-binding protein by an intermediary metabolite
eLife, 2014 Gene expression and metabolism are coupled at numerous levels. Cells must sense and respond to nutrients in their environment, and specialized cells must synthesize metabolic products required for their function.
Carina C Clingman +6 more
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RNA Epigenetics in Cancer: Current Knowledge and Therapeutic Implications
MedComm, Volume 6, Issue 8, August 2025.RNA epigenetics regulates cancer through RNA modifications, splicing, transport, and translation. Key components include m⁶A writers, splicing factors, RBPs, and nuclear export machinery. Aberrant RNA metabolism drives tumor progression and immune evasion.
Shanhe Huang +4 more
wiley +1 more source
CmFDa‐mediated epigenetic regulation of flowering in chrysanthemum
Plant Biotechnology Journal, Volume 23, Issue 7, Page 2720-2733, July 2025.Summary FD, a conserved bZIP transcription factor, is well known for its role in promoting flowering. Here, we uncover that a short coding sequence of the Chrysanthemum morifolium FD gene, CmFDa, represses flowering. Interestingly, we identified CmFDa as a novel epiallele stringently regulated by DNA methylation in chrysanthemum for the first time ...
Wanjie Xue +15 more
wiley +1 more source
Cancer Management and Research, 2020 Shouchao Li, Sheng Zheng Department of Anorectal Surgery, Weifang People’s Hospital, Weifang 261000, People’s Republic of ChinaCorrespondence: Sheng Zheng Email Zhengsheng966@163.comBackground: 5-fluorouracil, leucovorin, and oxaliplatin ...
Li S, Zheng S
doaj
Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer’s disease
Acta Neuropathologica Communications, 2018 Alzheimer’s disease (AD) is the most common neurodegenerative disorder associated with structural and functional alterations of brain cells causing progressive deterioration of memory and other cognitive functions. Recent studies demonstrate that several
Urmi Sengupta +5 more
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Cancer Management and Research, 2020 Bin Zhu,* Wei Liu,* Hongliang Liu, Qiang Xu, Wei Xu Department of Neurosurgery, Huashan North Hospital, Baoshan Branch, Fudan University, Shanghai 200431, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei ...
Zhu B, Liu W, Liu H, Xu Q, Xu W
doaj
Musashi-1 is the candidate of the regulator of hair cell progenitors during inner ear regeneration
BMC Neuroscience, 2017 Background Hair cell loss in the cochlea is caused by ototoxic drugs, aging, and environmental stresses and could potentially lead to devastating pathophysiological effects.
Takahiro Wakasaki +7 more
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