Neurogenèse dans les pathologies du système nerveux [PDF]
, 2005 Les cellules souches neurales (CSN) sont des cellules multipotentes, capables de s’autorenouveler et de produire différentes cellules du système nerveux : neurones, astrocytes et oligodendrocytes.
Taupin, Philippe
core +1 more source
NOTCH3 Signaling Regulates MUSASHI-1 Expression in Metastatic Colorectal Cancer Cells
Cancer Research, 2014 Abstract MUSASHI-1 (MSI-1) is a well-established stem cell marker in both normal and malignant colon cells and it acts by positively regulating the NOTCH pathway through inactivation of NUMB, a NOTCH signaling repressor. To date, the mechanisms of regulation of MSI-1 levels remain largely unknown.
Pasto A +14 more
openaire +5 more sources
Ekman Boundary Layers and Energy Dissipation in Rotating Drums During Spin-Down Process
International Journal of Rotating Machinery, 1995 The Laser Doppler Velocimetry (LDV) is employed to investigate energy dissipation during a spin-down process inside a rotating drum. The tracer/light sheet method is applied to observe flow patterns in the entire flow field from which the instantaneous ...
Hiroshi Ohue +2 more
doaj +1 more source
Communications Biology, 2022 The RNA-binding proteins, Musashi 1 and 2, regulate splicing of photoreceptor-specific alternative exons and activate protein expression, and are essential for promoting translation of proteins required for vision and photoreceptor survival.
Fatimah Matalkah +5 more
doaj +1 more source
Enhanced expression of the stemness-related factors OCT4, SOX15 and TWIST1 in ectopic endometrium of endometriosis patients [PDF]
, 2016 Background Current evidence suggests that endometrial-derived stem cells, spilled in the peritoneal cavity via retrograde menstruation, are key players in the establishment of endometriotic lesions. The aim of this study was to determine the presence and
Berthold Streubel +10 more
core +3 more sources
The RNA-Binding Protein Musashi1 Affects Medulloblastoma Growth via a Network of Cancer- Related Genes and Is an Indicator of Poor Prognosis [PDF]
, 2012 Musashi1 (Msi1) is a highly conserved RNA-binding protein that is required during the development of the nervous system. Msi1 has been characterized as a stem cell marker, controlling the balance between self-renewal and differentiation, and has also ...
Abreu, Raquel de Sousa +19 more
core +1 more source
Histone deacetylase 6 controls Notch3 trafficking and degradation in T-cell acute lymphoblastic leukemia cells [PDF]
, 2018 Several studies have revealed that endosomal sorting controls the steady-state levels of Notch at the cell surface in normal cells and prevents its inappropriate activation in the absence of ligands.
Agnusdei, Valentina +11 more
core +3 more sources
Increased number of neural progenitors in human temporal lobe epilepsy
Neurobiology of Disease, 2005 An increased neurogenesis is reported in animal models of mesial temporal lobe epilepsy (MTLE) but the fate of newborn cells is unknown. Here, we attempted to demonstrate neurogenesis in adult epileptic tissue obtained after hippocampectomy.
Arielle Crespel +8 more
doaj +1 more source
Nature Communications, 2022 MYC amplification is an independent prognostic factor for the most aggressive subgroup (Group 3) of pediatric medulloblastoma (G3 MB). Here, the authors highlight the role of the RNA-binding protein, Musashi-1 (MSI1) in G3 MB and identify MSI1-bound ...
Michelle M. Kameda-Smith +30 more
doaj +1 more source
The newt reprograms mature RPE cells into a unique multipotent state for retinal regeneration [PDF]
, 2014 The reprogramming of retinal pigment epithelium (RPE) cells in the adult newt immediately after retinal injury is an area of active research for the study of retinal disorders and regeneration.
Casco-Robles Martin Miguel +9 more
core +1 more source