Results 111 to 120 of about 28,480 (301)
Journal of Pharmacological Sciences, 2011 .: In small cell lung carcinoma (SCLC), acetylcholine (ACh) is synthesized and secreted, and it acts as an autocrine growth factor through activation of its receptors, muscarinic receptor (mAChR) and nicotinic receptor (nAChR). Alteration of tumor growth
Nozomi Ami +5 more
doaj
Influence of nano-TiO2 on functioning of gastric smooth muscles: in vitro and in silico studies
Біологічні студії, 2019 Nanosized materials, including titanium dioxide nanoparticles, sized under 10 nm, are systems with an excessive energy and high chemical activity, while the nanoparticles of about (1–3) nm enter the reactions with other chemical compounds practically ...
O. V. Tsymbalyuk +2 more
doaj +1 more source
Assessing the clinical value of fast onset and sustained duration of action of long-acting bronchodilators for COPD [PDF]
, 2015 Date of Aceptance: 12/02/2015 Acknowledgments The authors were assisted in the preparation of the manuscript by Sarah Filcek, a professional medical writer at CircleScience (Tytherington, UK), part of KnowledgePoint360, an Ashfield Company.
Beeh, Kai M +3 more
core +1 more source
Progress on the development of Class A GPCR‐biased ligands
British Journal of Pharmacology, Volume 182, Issue 14, Page 3249-3300, July 2025.Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales +20 more
wiley +1 more source
Signaling Bias and Antagonism of Pilocarpine for M3 Muscarinic Acetylcholine Receptor
The FASEB Journal, 2018 Pilocarpine is a prototypical drug used to treat glaucoma and dry mouth since the 19th century and classified as either a full or partial muscarinic agonist. Here, we report several unexpected results pertaining to its interaction with its main therapeutic target ‐ muscarinic M3 receptor (M3R).
Kelly Wang +2 more
openaire +1 more source
Frontiers in Neural Circuits, 2022 The neuromodulator acetylcholine (ACh) plays an important role in arousal, attention, vigilance, learning and memory. ACh is released during different behavioural states and affects the brain microcircuit by regulating neuronal and synaptic properties ...
Guanxiao Qi +3 more
doaj +1 more source
Cholinergic switch between two types of slow waves in cerebral cortex [PDF]
Cerebral Cortex 2019, 2018 Sleep slow waves are known to participate in memory consolidation, yet slow waves occurring under anesthesia present no positive effects on memory. Here, we shed light onto this paradox, based on a combination of extracellular recordings in vivo, in vitro, and computational models.
arxiv +1 more source
Non-Neuronal Functions of the M2 Muscarinic Acetylcholine Receptor [PDF]
, 2013 Acetylcholine is an important neurotransmitter whose effects are mediated by two classes of receptors. The nicotinic acetylcholine receptors are ion channels, whereas the muscarinic receptors belong to the large family of G protein coupled seven ...
Acevedo +58 more
core +3 more sources
BMC Gastroenterology, 2010 Background Autoantibodies to the human muscarinic acetylcholine receptor of the M3 type (hmAchR M3) have been suggested to play an etiopathogenic role in Sjögren's syndrome.
Berg Peter A +6 more
doaj +1 more source
A factor graph EM algorithm for inference of kinetic microstates from patch clamp measurements [PDF]
arXiv, 2021 We derive a factor graph EM (FGEM) algorithm, a technique that permits combined parameter estimation and statistical inference, to determine hidden kinetic microstates from patch clamp measurements. Using the cystic fibrosis transmembrane conductance regulator (CFTR) and nicotinic acetylcholine receptor (nAChR) as examples, we perform {\em Monte Carlo}
arxiv