Neuroimmune interactions: The bridge between inflammatory bowel disease and the gut microbiota
Clinical and Translational Medicine, Volume 15, Issue 5, May 2025.The gut microbiota regulates the gut–brain–immune axis, modulating neuroimmune interactions in inflammatory bowel disease (IBD). Microbiota‐derived metabolites influence immune cells, driving cytokine release that activates dorsal root ganglion (DRG) neurons.
Jinxia Zhai +3 more
wiley +1 more source
The mechanisms of calcium homeostasis and signalling in the lens [PDF]
, 2008 Excessive Ca2+ can be detrimental to cells and raised levels of Ca2+ in human lenses with cortical cataract have been found to play a major role in the opacification process.
Rhodes, JD, Sanderson, J
core +1 more source
Neurourology and Urodynamics, Volume 44, Issue 3, Page 568-576, March 2025.ABSTRACT Aims To answer the question of whether the bladder itself can to any extent control or modulate the initiation of voiding. Methods This subject was discussed at the International Consultation on Incontinence‐Research Society (ICI‐RS) 2024 conference in Bristol, UK in a proposal session.
Gommert Van Koeveringe +7 more
wiley +1 more source
Using molecular dynamics for the refinement of atomistic models of GPCRs by homology modeling [PDF]
, 2017 Despite GPCRs sharing a common seven helix bundle, analysis of the diverse crystallographic structures available reveal specific features that might be relevant for ligand design.
Gómez Gutiérrez, Patricia +3 more
core +2 more sources
The m3 muscarinic acetylcholine receptor is coupled to mitogen-activated protein kinase via protein kinase C and epidermal growth factor receptor kinase [PDF]
, 2000 Barbara E. Slack
openalex +2 more sources
The substrate of the biopsychosocial influences in the carcinogenesis of the digestive tract [PDF]
, 2016 Digestive cancer represents a severe public health problem, being one of the main causes of death. It is considered a multifactorial disease, with hereditary predisposition, environmental factors, and other factors involved in carcinogenesis.
Caragea, Daniel +5 more
core +3 more sources
Modulation of c-Jun NH2-Terminal (JNK) by Cholinergic Autoantibodies from Patients with Sjögren’s Syndrome [PDF]
, 2011 Background: We wanted to determine (via an immunopharmacological approach) whether the c-Jun NH2 terminal kinase (JNK) cascade is phosphorylated in the submandibular gland by carbachol and cholinergic autoantibodies (IgG) present in the sera of patients ...
Borda, Enri Santiago +3 more
core +1 more source
New and developing non-adrenoreceptor small molecule drugs for the treatment of asthma [PDF]
, 2017 Introduction: Inhaled corticosteroids (ICS) alone or in combination with an inhaled long-acting beta2-agonist (LABA) are the preferred long-term treatment for adults and adolescents with symptomatic asthma.
Thomson, Neil C.
core +1 more source
Muscarinic Acetylcholine Receptor M3 Expression and Survival in Human Colorectal Carcinoma-An Unexpected Correlation to Guide Future Treatment? [PDF]
Int J Mol Sci, 2023 Lobbes LA +7 more
europepmc +1 more source
Calcium Mobilization by Activation of M3/M5 Muscarinic Receptors in the Human Retinoblastoma
Journal of Pharmacological Sciences, 2007 Activation of muscarinic acetylcholine receptors (mAChR) is one of the most important signal transduction pathways in the human body. In this study, we investigated the role of mAChR activation in relation to its subtypes in human retinoblastoma cell ...
Dae-Ran Kim +8 more
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