Results 111 to 120 of about 13,431 (223)

Ligand-guided homology modeling drives identification of novel histamine H3 receptor ligands [PDF]

, 2019
In this study, we report a ligand-guided homology modeling approach allowing the analysis of relevant binding site residue conformations and the identification of two novel histamine H3 receptor ligands with binding affinity in the nanomolar range.
Hagenow, Stefanie, Schaller, David, Stark, Holger, Wolber, Gerhard   +3 more
core   +2 more sources

Anti-M3 muscarinic acetylcholine receptor antibodies in systemic lupus erythematosus

, 2015
Fil: Pisoni, Cecilia.
Reina, Silvia Lorena, Pisoni, Cecilia, Eimon, Alicia, Carrizo, Carolina, Arana, Roberto, Borda, Enri Santiago   +5 more
openaire   +2 more sources

Role of M3 Muscarinic Acethylcholine Receptor Antibodies as a New Marker in Primary Sjögren Syndrome [PDF]

, 2017
Aims: This paper investigates the presence of M3 muscarinic acetylcholine receptor autoantibody present in the serum of patients with primary Sjögren syndrome (pSS).
Borda, Enri Santiago, Ganzinelli, Sabrina Belen, González Arana, Roberto, Pisoni, Cecilia, Reina, Silvia Lorena   +4 more
core   +1 more source

Muscarinic cannabinoid suppression of excitation, a novel form of coincidence detection

Pharmacological Research
Δ9-tetrahydrocannabinol (THC), the chief psychoactive ingredient of cannabis, acts in the brain primarily via cannabinoid CB1 receptors. These receptors are implicated in several forms of synaptic plasticity – depolarization-induced suppression of ...
Michaela Dvorakova, Ken Mackie, Alex Straiker   +2 more
doaj   +1 more source

Atropine can induce autophagy independent of the M3 muscarinic acetylcholine receptor

, 2022
Abstract Atropine is a well-known muscarinic acetylcholine receptor (mAchR) antagonist; it has been used widely in medicine in that role. Autophagy plays an important role in many physiological processes. In this study, human renal epithelium (293T) cells were treated with different physiological regulators.
Xin Liu, hong chen, Na-na Yi, Tian-fei Yu, Hai-chang Yin   +4 more
openaire   +1 more source

M3 muscarinic acetylcholine receptors regulate epithelial–mesenchymal transition, perineural invasion, and migration/metastasis in cholangiocarcinoma through the AKT pathway

Cancer Cell International, 2018
Background Cholangiocarcinoma is a highly malignant tumor type that is not sensitive to radiotherapy or chemotherapy due to aggressive perineural invasion and metastasis.
Yujie Feng, Xiao Hu, Guangwei Liu, Lianfang Lu, Wei Zhao, Fangzhen Shen, Kai Ma, Chuandong Sun, Chengzhan Zhu, Bingyuan Zhang   +9 more
doaj   +1 more source

Muscarinic Acetylcholine Receptor M3 Expression and Survival in Human Colorectal Carcinoma-An Unexpected Correlation to Guide Future Treatment? [PDF]

Int J Mol Sci, 2023
Lobbes LA, Schütze MA, Droeser R, Arndt M, Pozios I, Lauscher JC, Hering NA, Weixler B.   +7 more
europepmc   +1 more source

Assessment of the molecular mechanisms of action of novel 4-phenylpyridine-2-one and 6-phenylpyrimidin-4-one allosteric modulators at the M1 muscarinic acetylcholine receptors [PDF]

, 2018
Positive allosteric modulators (PAMs) that target the M1 muscarinic acetylcholine (ACh) receptor (M1 mAChR) are potential treatments for cognitive deficits in conditions such as Alzheimer's disease and schizophrenia.
Andrew B. Tobin, Arthur Christopoulos, Arthur Spathis, Ben Capuano, Celine Valant, Davoren, Ehlert, Ehlert, Elham Khajehali, Emma T. van der Westhuizen, Furchgott, Manuela Jörg, Mistry, Patrick M. Sexton, Peter J. Scammells, Shailesh N. Mistry   +15 more
core   +2 more sources

Reduced M3 muscarinic acetylcholine receptor expression in gestational diabetes mellitus: implications for placental dysfunction and vascular regulation

The Journal of Maternal-Fetal & Neonatal Medicine
Objectives Gestational diabetes mellitus (GDM) is a prevalent metabolic disorder affecting pregnancy, leading to significant maternal and fetal complications.
Süleyman Cemil Oğlak, Fırat Aşır, Tuğcan Korak, Ayşegül Aşır, Emine Zeynep Yılmaz, Elif Ağaçayak   +5 more
doaj   +1 more source

Effect of Eugenol on Detrusor Muscle: Potential for Overactive Bladder Treatment [PDF]

International Neurourology Journal
Purpose This investigation was conducted to elucidate the effects of eugenol on bladder contractility through experimental and in silico approaches. Methods To assess the impact of eugenol on muscular contractility, longitudinal strips of bladder tissue,
Marília Cavalcante Araújo, Átila Pereira-Gonçalves, André Nogueira Cardeal dos Santos, José Ednésio da Cruz Freire, Luís Peireira-de-Morais, Francisco Sydney Henrique-Félix, Nicoly Câmara Castro Sousa-Júlio, José Henrique Leal-Cardoso, Andrelina Noronha Coelho-de-Souza   +8 more
doaj   +1 more source