Results 141 to 150 of about 28,480 (301)
The mechanisms of calcium homeostasis and signalling in the lens [PDF]
, 2008 Excessive Ca2+ can be detrimental to cells and raised levels of Ca2+ in human lenses with cortical cataract have been found to play a major role in the opacification process.
Rhodes, JD, Sanderson, J
core +1 more source
Immunological Reviews, Volume 330, Issue 1, March 2025.ABSTRACT Asthma has become more appreciated for its heterogeneity with studies identifying type 2 and non‐type 2 phenotypes/endotypes that ultimately lead to airflow obstruction, airway hyperresponsiveness, and remodeling. The pro‐inflammatory environment in asthma influences airway smooth muscle (ASM) structure and function.
Maria L. Ford +4 more
wiley +1 more source
Journal of Neurochemistry, Volume 169, Issue 3, March 2025.We used advanced tools called DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) to control the activity of inhibitory neurons versus excitatory neurons in the hippocampus, a region of the brain critical for learning and memory. By activating or inactivating these neurons after training, we found that disrupting their normal activity ...
Ziying Huang +4 more
wiley +1 more source
Neurocardiology: translational advancements and potential
The Journal of Physiology, Volume 603, Issue 7, Page 1729-1779, 31 March 2025.Abstract figure legend Afferent signalling pathways of the autonomic nervous system and their efferent targets in the heart, kidneys and vasculature. Abstract In our original white paper published in the The Journal of Physiology in 2016, we set out our knowledge of the structural and functional organization of cardiac autonomic control, how it ...
N. Herring +13 more
wiley +1 more source
The m3 muscarinic acetylcholine receptor is coupled to mitogen-activated protein kinase via protein kinase C and epidermal growth factor receptor kinase [PDF]
, 2000 Barbara E. Slack
openalex +2 more sources
Boundary lipids of the nicotinic acetylcholine receptor: spontaneous partitioning via coarse-grained molecular dynamics simulation [PDF]
arXiv, 2018 Reconstituted nicotinic acetylcholine receptors (nAChRs) exhibit significant gain-of-function upon addition of cholesterol to reconstitution mixtures, and cholesterol affects organization of nAChRs within domain-forming membranes, but whether nAChR partitions to cholesterol-rich liquid-ordered ("raft" or $l_o$) domains or cholesterol-poor liquid ...
arxiv
Opening a hydrophobic gate: the nicotinic acetylcholine receptor as an example [PDF]
arXiv, 2009 To what extent must a hydrophobic gate expand for the channel to count as open? We address this question using the nicotinic acetylcholine receptor (nAChR) as the exemplar. The nAChR is an integral membrane protein which forms a cation selective channel gated by neurotransmitter binding to its extracellular domain.
arxiv
Characterization of a new muscarinic toxin from the venom of the Brazilian coral snake Micrurus lemniscatus in rat hippocampus [PDF]
, 2011 AimsWe have isolated a new muscarinic protein (MT-Mlα) from the venom of the Brazilian coral snake Micrurus lemniscatus.Main methodsThis small protein, which had a molecular mass of 7,048Da, shared high sequence homology with three-finger proteins that ...
Abdalla, Fernando Maurício Francis +6 more
core +1 more source
Cancer Cell International, 2018 Background Cholangiocarcinoma is a highly malignant tumor type that is not sensitive to radiotherapy or chemotherapy due to aggressive perineural invasion and metastasis.
Yujie Feng +9 more
doaj +1 more source
Using molecular dynamics for the refinement of atomistic models of GPCRs by homology modeling [PDF]
, 2017 Despite GPCRs sharing a common seven helix bundle, analysis of the diverse crystallographic structures available reveal specific features that might be relevant for ligand design.
Gómez Gutiérrez, Patricia +3 more
core +2 more sources