Results 151 to 160 of about 6,851 (178)

Identification of a novel protein partner of the M3 muscarinic acetylcholine receptor

The FASEB Journal, 2008
The M 3 muscarinic acetylcholine receptor is widely expressed throughout the central nervous system and is also found in many peripheral tissues and cell types. Several lines of work suggest that drugs acting on central or peripheral M 3 receptors might
Rosemond E, SCARSELLI, MARCO, De Azua I. Ruiz, Wess J.   +3 more
openaire   +2 more sources

Interaction of Edrophonium with Muscarinic Acetylcholine M2and M3Receptors

Anesthesiology, 2001
Background It has been reported that edrophonium can antagonize the negative chronotropic effect of carbachol. This study was undertaken to evaluate in detail the interaction of edrophonium with muscarinic Mz and M3 receptors. Methods A functional study was conducted to evaluate the
Y, Tanito, T, Miwa, M, Endou, Y, Hirose, M, Gamoh, H, Nakaya, F, Okumura   +6 more
openaire   +2 more sources

M3 muscarinic acetylcholine receptor antagonists: SAR and optimization of bi-aryl amines

Bioorganic & Medicinal Chemistry Letters, 2009
Exploration of multiple regions of a bi-aryl amine template led to the identification of highly potent M(3) muscarinic acetylcholine receptor antagonists such as 14 (pA(2)=11.0) possessing good sub-type selectivity for M(3) over M(2). The structure-activity relationships (SAR) and optimization of the bi-aryl amine series are described.
Brian, Budzik, Yonghui, Wang, Dongchuan, Shi, Feng, Wang, Haibo, Xie, Zehong, Wan, Chongye, Zhu, James J, Foley, Parvathi, Nuthulaganti, Lorena A, Kallal, Henry M, Sarau, Dwight M, Morrow, Michael L, Moore, Ralph A, Rivero, Michael, Palovich, Michael, Salmon, Kristen E, Belmonte, Dramane I, Laine, Jian, Jin   +18 more
openaire   +2 more sources

Role of microtubule structure in the maintenance of m3-muscarinic acetylcholine receptor rnRNA levels

Molecular and Cellular Neuroscience, 1991
The regulation of m3-muscarinic acetylcholine receptor (mAChR) mRNA following exposure to microtubule-disrupting agents was studied in cultured cerebellar granule cells. Colchicine (10 muM), an antimicrotubular agent, decreased the levels of m3-mAChR mRNA in a time-dependent fashion.
F, Fukamauchi, C, Hough, D M, Chuang
openaire   +2 more sources

Muscarinic Stimulation of Pancreatic Insulin and Glucagon Release Is Abolished in M3 Muscarinic Acetylcholine Receptor–Deficient Mice

Diabetes, 2004
Pancreatic muscarinic acetylcholine receptors play an important role in stimulating insulin and glucagon secretion from islet cells. To study the potential role of the M3 muscarinic receptor subtype in cholinergic stimulation of insulin release, we initially examined the effect of the muscarinic agonist, oxotremorine-M (Oxo-M), on insulin secretion ...
Alokesh, Duttaroy, Charles L, Zimliki, Dinesh, Gautam, Yinghong, Cui, David, Mears, Jürgen, Wess   +5 more
openaire   +2 more sources

Ligand-Induced Activation of the M3-Muscarinic Acetylcholine Receptor

This thesis explores the computer-aided drug design of the M3-muscarinic acetylcholine receptor in three chapters. The first chapter focuses on molecular docking to identify novel agonists using the ZINC12 library. A model of the M3 receptor was built based on the M2 receptor.
openaire   +1 more source

M3 muscarinic acetylcholine receptor in cardiology and oncology

International Journal of Cardiology, 2014
openaire   +2 more sources

Muscarinic Acetylcholine Receptor M3

2020
openaire   +1 more source

Primary structure of porcine cardiac muscarinic acetylcholine receptor deduced from the cDNA sequence

FEBS Letters, 1986
Tai Kubo, Akito Maeda, Katsunori Sugimoto   +2 more
exaly  

M3 Muscarinic Acetylcholine Receptor

2007
openaire   +1 more source