Results 1 to 10 of about 7,801 (240)

The M3 Muscarinic Acetylcholine Receptor Promotes Epidermal Differentiation [PDF]

Journal of Investigative Dermatology, 2022
The M3 muscarinic acetylcholine receptor is predominantly expressed in the basal epidermal layer where it mediates the effects of the autocrine/paracrine cytotransmitter acetylcholine.
Junyan Duan, Charles Grando, Shuman Liu   +2 more
exaly   +9 more sources

Allosteric interactions at the M3 muscarinic acetylcholine receptor [PDF]

, 2008
The extracellular loops of muscarinic acetylcholine receptors are predicted to play a role in the binding and regulation of allosteric modulators. Furthermore, the sequence of the five subtypes of muscarinic receptors shows a large degree of diversity in
Iarriccio Silva, Laura
core   +7 more sources

Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists [PDF]

Proc Natl Acad Sci U S A, 2018
Drugs that treat chronic obstructive pulmonary disease by antagonizing the M3 muscarinic acetylcholine receptor (M3R) have had a significant effect on health, but can suffer from their lack of selectivity against the M2R subtype, which modulates heart ...
Bartuschat, Amelie, Sunahara, Roger K, Fisher, John T, Hirata, Kunio, Banerjee, Ashutosh, Heinrich, Markus R, Kobilka, Brian K, Liu, Xiangyu, Fish, Inbar, Schaake, Benjamin, Eitel, Katrin, Gmeiner, Peter, Shoichet, Brian K, Hofmann, Josefa, Clark, Mary J, Kaindl, Jonas, Rampp, Hannelore, Hübner, Harald, Liu, Hongtao, Vincent, Sandra G   +19 more
core   +7 more sources

Muscarinic acetylcholine receptor M1 and M3 subtypes mediate acetylcholine-induced endothelium-independent vasodilatation in rat mesenteric arteries [PDF]

Journal of Pharmacological Sciences, 2016
The present study investigated pharmacological characterizations of muscarinic acetylcholine receptor (AChR) subtypes involving ACh-induced endothelium-independent vasodilatation in rat mesenteric arteries.
Panot Tangsucharit, Takatori, Shingo, Zamami, Yoshito, Poungrat Pakdeechote, Takayama, Fusako, Kawasaki, Hiromu, Shingo Takatori, Mitsuhiro Goda, Yoshito Zamami, Fusako Takayama, Hiromu Kawasaki, Tangsucharit, Panot, Goda, Mitsuhiro, Pakdeechote, Poungrat   +13 more
core   +4 more sources

Muscarinic acetylcholine receptor m3 mutation causes urinary bladder disease and a prune-belly-like syndrome [PDF]

, 2011
Urinary bladder malformations associated with bladder outlet obstruction are a frequent cause of progressive renal failure in children. We here describe a muscarinic acetylcholine receptor M3 (CHRM3) (1q41-q44) homozygous frameshift mutation in familial ...
Woolf, A.S., Sozeri, Betül, Mohammad Reza Toliat, Thiele, H., Schaefer, F., Konrad, Martin, Woolf, Adrian S.; id_orcid, William G. Newman, Altmüller, Janine, Duncan T. Wilcox, Stefanie Weber, Neil A. Hanley, Schlingmann, Karl Peter, Betül Sozeri, Jennings, Rachel, Thiel, U., Thiele, Holger, Stuart, Helen M., Janine Altmüller, Reutter, H., Nürnberg, P., Peter Frommolt, Uwe Thiel, Frommolt, P., Frommolt, Peter, Franz Schaefer, Mir, S., Reutter, Heiko, Adrian S. Woolf, Karl Peter Schlingmann, Michael Ludwig, Martin Konrad, Ludwig, Michael, Woolf, Adrian S., Schlingmann, K.P., Newman, William G., Sozeri, B., Hoyer, Peter F., Toliat, M.R., Stuart, H.M, Jennings, R., Hanley, Neil A., Hoyer, P.F., Schaefer, Franz, Rolf Beetz, Markus Draaken, Ranjzad, P., Helen M. Stuart, Weber, Stefanie, Toliat, Mohammad Reza, Draaken, M., Hanley, Neil A.; id_orcid, Beetz, Rolf, Parisa Ranjzad, Rachel Jennings, Hanley, N.A., Heiko Reutter, Draaken, Markus, Mir, Sevgi, Nürnberg, Peter, Peter Nürnberg, Thiel, Uwe, Holger Thiele, Newman, W.G., Wilcox, D.T., Peter F. Hoyer, Ludwig, M., Altmüller, J., Konrad, M., Wilcox, Duncan T., Beetz, R., Ranjzad, Parisa, Newman, William G.; id_orcid, Sevgi Mir, Weber, S.   +74 more
core   +3 more sources

Eosinophil-mediated cholinergic nerve remodeling [PDF]

, 2006
Eosinophils are observed to localize to cholinergic nerves in a variety of inflammatory conditions such as asthma, rhinitis, eosinophilic gastroenteritis, and inflammatory bowel disease, where they are also responsible for the induction of cell ...
McLean, W.G., Anthony G. Fenech, Madziar, B., Madziar, Beata, Durcan, Niamh, Gleich, G.J., Walsh, M., Fenech, Anthony G., McLean, Graham W., Jan Blusztajn, Gerard J. Gleich, Gleich, Gerard J., Niamh Durcan, Hall, Ian P., Beata Madziar, Walsh, Marie-Therese, Hall, I.P., Ian P. Hall, Durcan, N., Costello, Richard W., Richard W. Costello, Marie-Therese Walsh, McGarvey, Lorcan, Costello, R.W., Fenech, A.G., W. Graham McLean, Lorcan McGarvey, Blusztain, J., Blusztajn, Jan   +28 more
core   +1 more source

Ligand regulation of the quaternary organization of cell surface M3 muscarinic acetylcholine receptors analyzed by fluorescence resonance energy transfer (FRET) imaging and homogenous time-resolved FRET [PDF]

, 2010
Flp-In T-REx 293 cells expressing a wild type human M muscarinic acetylcholine receptor construct constitutively and able to express a Receptor Activated Solely by Synthetic Ligand (RASSL) form of this receptor on demand maintained response to the ...
Alvarez-Curto, Elisa, Ward, Richard J., Milligan, Graeme, Pediani, John D.   +3 more
core   +1 more source

The interaction of tiotropium with long lasting β2-agonists on lung cell function [PDF]

, 2013
The major question addressed in this thesis was to find the mechanism(s) by which muscarinic receptors interact with β2-adrenergic receptors in human airway fibroblasts.
Costa, Luigi
core   +1 more source

The Effects of the Selective Muscarinic M3 Receptor Antagonist Darifenacin, and of Hyoscine (scopolamine), on Motion Sickness, Skin Conductance & Cognitive Function [PDF]

, 2018
Aims: The aim of this study was to compare the effects of the selective M3 muscarinic acetylcholine receptor antagonist Darifenacin, oral Hyoscine hydrobromide and Placebo on motion sickness induced by cross-coupled stimulation.
Brian R. Leaker, Leaker, B.R., Wesnes, K.A., John F. Golding, Keith A. Wesnes, Golding, J.F.   +5 more
core   +1 more source

Distinct agonist regulation of muscarinic acetylcholine M2-M3 heteromers and their corresponding homomers [PDF]

, 2015
Each subtype of the muscarinic receptor family of G protein-coupled receptors is activated by similar concentrations of the neurotransmitter acetylcholine or closely related synthetic analogs such as carbachol. However, pharmacological selectivity can be
Alvarez-Curto, Elisa, Marsango, Sara, Aslanoglou, Despoina, Milligan, Graeme   +3 more
core   +1 more source