Results 1 to 10 of about 6,851 (178)

Molecular mechanism of muscarinic acetylcholine receptor M3 interaction with Gq [PDF]

Communications Biology
Muscarinic acetylcholine receptor M3 (M3) and its downstream effector Gq/11 are critical drug development targets due to their involvement in physiopathological processes.
Donghee Ham, Asuka Inoue, Jun Xu, Yang Du, Ka Young Chung   +4 more
doaj   +4 more sources

Antibodies to the Muscarinic Acetylcholine Receptor M3 in Primary Biliary Cholangitis Inhibit Receptor Function on Cholangiocytes [PDF]

Frontiers in Immunology, 2020
Background and Aims: In primary biliary cholangitis (PBC), antibodies to a peptide of the muscarinic acetylcholine receptor 3 (mAChR3) have been described.
Christian Mayer, Beate Preuss, Julia Grottenthaler, Christoph Berg, Reinhild Klein   +4 more
doaj   +2 more sources

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Successful Therapeutic Plasma Exchange Treatment After SARS-CoV-2 Infection-A Case Report. [PDF]

Clin Case Rep
This schematic timeline of symptom progression, infectious history, autoantibody dynamics, and therapeutic interventions illustrates the clinical course of our patient with long‐standing ME/CFS, showing initial improvement during Raltegravir therapy, subsequent symptom worsening following SARS‐CoV‐2 infection with rising autoantibody levels, and ...
Ciobanu G, Arn N.
europepmc   +2 more sources

Anti‐M3 Muscarinic Acetylcholine Receptor Autoantibody in the Serum and Saliva of Oral Lichen Planus Patients: A Case‐Control Study [PDF]

Health Science Reports
Background and Aims Oral lichen planus OLP) is a chronic, T‐cell–mediated disease frequently accompanied by xerostomia. Prior work suggests reduced salivary M3 muscarinic acetylcholine receptor (M3R) may contribute to hyposalivation.
Farzaneh Agha‐hosseini, Mahsa Koochaki, Mahdieh‐Sadat Moosavi, Iraj Mirzaei‐Dizgah, Mina Khayamzadeh   +4 more
doaj   +2 more sources

Synergistic mechanisms of medullary cholinergic-serotonergic pathway interactions in regulating neuronal excitability and locomotor activities [PDF]

Communications Biology
Medullary serotonergic (5-HT) neurons play a pivotal role in locomotor initiation. While these neurons receive cholinergic innervation, the functional consequences and underlying mechanisms remain poorly understood. Using ePet-EYFP transgenic mice (P3–P6)
Yi Cheng, Yue Dai, Renkai Ge, Qiang Zhang   +3 more
doaj   +2 more sources

Dualsteric Agonist for M2 Muscarinic Receptor Causes Oxidative Stress and Mitochondrial Alteration in Human Glioblastoma Cancer Stem Cells. [PDF]

J Neurochem
Dualsteric agonist N8‐iper shows cytotoxic effects on glioblastoma cancer stem cells, but not on human normal astrocytes. Lipid accumulation appears as a consequence of cytotoxic stress; in fact, they are not present in healthy astrocytes. ABSTRACT Glioblastoma (GB) is the most malignant form of human brain tumor, characterized by heterogeneous cell ...
Guerriero C, De Nuccio C, Petrone M, Rinaldi T, Cirigliano A, Visentin S, Bernardo A, Conti L, Matera C, De Amici M, Dallanoce C, Tata AM.   +11 more
europepmc   +2 more sources

Muscarinic receptor M3 contributes to intestinal stem cell maintenance via EphB/ephrin-B signaling

Life Science Alliance, 2021
A signaling cascade composing M3, EphB/ephrin-B, and MEK synergizes to guide the homeostasis of intestinal epithelial cell growth and differentiation following modifications of the cholinergic intestinal niche.
Toshio Takahashi, Akira Shiraishi, Jun Murata, Shin Matsubara, Satsuki Nakaoka, Shinji Kirimoto, Masatake Osawa   +6 more
doaj   +1 more source

General anaesthesia-related complications of gut motility with a focus on cholinergic mechanisms, TRP channels and visceral pain

Frontiers in Physiology, 2023
General anesthesia produces multiple side effects. Notably, it temporarily impairs gastrointestinal motility following surgery and causes the so-called postoperative ileus (POI), a multifactorial and complex condition that develops secondary to ...
Alexander V. Zholos, Dariia O. Dryn, Mariia I. Melnyk, Mariia I. Melnyk   +3 more
doaj   +1 more source

New promising agents against COPD and asthma among the amides of 1-oxo-3-phenyl-isochroman-6-carboxylic acid

Біофізичний вісник, 2023
Background: Bronchodilators, which are compounds that can relax airway smooth muscle, are perhaps the most important component of combination therapy for chronic obstructive pulmonary disease, one of the most common non-communicable diseases in the world,
Олексій Нипорко, Ольга Цимбалюк, Іван Войтешенко, Сергій Старосила, Микола Протопопов, Володимир Бджола   +5 more
doaj   +1 more source

M3 subtype of muscarinic acetylcholine receptor promotes cardioprotection via the suppression of miR-376b-5p. [PDF]

PLoS ONE, 2012
The M(3) subtype of muscarinic acetylcholine receptors (M(3)-mAChR) plays a protective role in myocardial ischemia and microRNAs (miRNAs) participate in many cardiac pathophysiological processes, including ischemia-induced cardiac injury.
Zhenyu Pan, Yueping Guo, Hanping Qi, Kai Fan, Shu Wang, Hua Zhao, Yuhua Fan, Jing Xie, Feng Guo, Yunlong Hou, Ning Wang, Rong Huo, Yong Zhang, Yan Liu, Zhimin Du   +14 more
doaj   +1 more source