Results 21 to 30 of about 13,541 (253)

Activation State of the M3 Muscarinic Acetylcholine Receptor Modulates Mammalian Odorant Receptor Signaling [PDF]

Science Signaling, 2011
Crosstalk between neurotransmitter signaling and odorant signaling may enhance the sense of smell.
Yun Rose Li, Hiroaki Matsunami
openalex   +4 more sources

Expression of M3 muscarinic acetylcholine receptors in gastric cancer

Romanian Journal of Morphology and Embryology, 2022
Gastric cancer represents a real public health problem as far as incidence, aggressiveness and unfavorable prognosis are concerned. The autonomous nervous system might be one of the major factors involved in the onset, progression, and metastasis, both sympathetically and parasympathetically.
Mehedinţeanu, Alina Maria, Mirea, Cecil Sorin, Stovicek, Puiu Olivian, Schenker, Michael, Stancu, Marius Ionuţ, Ciurea, Ana-Maria, Streba, Liliana, Istrate-Ofiţeru, Anca-Maria, Sas, Teodor-Nicuşor, Vere, Cristin Constantin   +9 more
openaire   +2 more sources

Muscarinic receptor M3 contributes to intestinal stem cell maintenance via EphB/ephrin-B signaling

Life Science Alliance, 2021
A signaling cascade composing M3, EphB/ephrin-B, and MEK synergizes to guide the homeostasis of intestinal epithelial cell growth and differentiation following modifications of the cholinergic intestinal niche.
Toshio Takahashi, Akira Shiraishi, Jun Murata, Shin Matsubara, Satsuki Nakaoka, Shinji Kirimoto, Masatake Osawa   +6 more
doaj   +1 more source

Random Mutagenesis of the M3 Muscarinic Acetylcholine Receptor Expressed in Yeast [PDF]

Journal of Biological Chemistry, 2003
Clarice Schmidt, Bo Li, Lanh M. Bloodworth, Isolde Erlenbach, Fu‐Yue Zeng, Jürgen Wess   +5 more
openalex   +2 more sources

Molecular Modeling of the M3 Acetylcholine Muscarinic Receptor and Its Binding Site [PDF]

Journal of Biomedicine and Biotechnology, 2012
The present study reports the results of a combined computational and site mutagenesis study designed to provide new insights into the orthosteric binding site of the human M3 muscarinic acetylcholine receptor. For this purpose a three-dimensional structure of the receptor at atomic resolution was built by homology modeling, using the crystallographic ...
Marlet Martínez‐Archundia, Arnau Cordomí, Pere Garriga, Juan J. Pérez   +3 more
openalex   +4 more sources

Inhibition of m3 muscarinic acetylcholine receptors by local anaesthetics [PDF]

British Journal of Pharmacology, 2001
Muscarinic m1 receptors are inhibited by local anaesthetics (LA) at nM concentrations. To elucidate in more detail the site(s) of LA interaction, we compared these findings with LA effects on m3 muscarinic receptors. We expressed receptors in Xenopus oocytes.
Hollmann, M. W., Ritter, C. H., Henle, P., de Klaver, M., Kamatchi, G. L., Durieux, M. E.   +5 more
openaire   +3 more sources

General anaesthesia-related complications of gut motility with a focus on cholinergic mechanisms, TRP channels and visceral pain

Frontiers in Physiology, 2023
General anesthesia produces multiple side effects. Notably, it temporarily impairs gastrointestinal motility following surgery and causes the so-called postoperative ileus (POI), a multifactorial and complex condition that develops secondary to ...
Alexander V. Zholos, Dariia O. Dryn, Mariia I. Melnyk, Mariia I. Melnyk   +3 more
doaj   +1 more source

New promising agents against COPD and asthma among the amides of 1-oxo-3-phenyl-isochroman-6-carboxylic acid

Біофізичний вісник, 2023
Background: Bronchodilators, which are compounds that can relax airway smooth muscle, are perhaps the most important component of combination therapy for chronic obstructive pulmonary disease, one of the most common non-communicable diseases in the world,
Олексій Нипорко, Ольга Цимбалюк, Іван Войтешенко, Сергій Старосила, Микола Протопопов, Володимир Бджола   +5 more
doaj   +1 more source

Novel Insights into M3 Muscarinic Acetylcholine Receptor Physiology and Structure [PDF]

Journal of Molecular Neuroscience, 2013
Recent studies with M3 muscarinic acetylcholine receptor (M3R) mutant mice suggest that drugs selectively targeting this receptor subtype may prove useful for the treatment of various pathophysiological conditions. Moreover, the use of M3R-based designer G protein-coupled receptors (GPCRs) has provided novel insights into how Gq-coupled GPCRs can ...
Andrew C, Kruse, Jianhua, Li, Jianxin, Hu, Brian K, Kobilka, Jürgen, Wess   +4 more
openaire   +2 more sources

Antibodies against 25-mer synthetic peptide of M3 muscarinic acetylcholine receptor [PDF]

, 2004
Polona Žigon, Alojzija Hočevar, Saša Čučnik, Borut Božič, B Rozman, Matija Tomšič, Tanja Kveder   +6 more
openalex   +2 more sources