Results 21 to 30 of about 7,801 (240)

Activation State of the M3 Muscarinic Acetylcholine Receptor Modulates Mammalian Odorant Receptor Signaling [PDF]

Science Signaling, 2011
Crosstalk between neurotransmitter signaling and odorant signaling may enhance the sense of smell.
Yun Rose Li, Hiroaki Matsunami
openalex   +4 more sources

Aged Mice Devoid of the M3 Muscarinic Acetylcholine Receptor Develop Mild Dry Eye Disease [PDF]

Int J Mol Sci, 2021
The parasympathetic nervous system is critically involved in the regulation of tear secretion by activating muscarinic acetylcholine receptors. Hence, various animal models targeting parasympathetic signaling have been developed to induce dry eye disease
Panagiotis Chronopoulos, Yue Ruan, Subao Jiang, Aytan Musayeva, Huige Li, Jenia Kouchek Zadeh, Werner E.G. Müller, Adrian Gericke, Maximilian Ackermann, Ning Xia, Norbert Pfeiffer   +10 more
core   +2 more sources

M3 muscarinic acetylcholine receptor-reactive Th17 cells in primary Sjögren's syndrome. [PDF]

JCI Insight, 2020
M3 muscarinic acetylcholine receptor (M3R) is one of the autoantigens associated with Sjögren's syndrome (SS) and is localized in exocrine glands where disease-specific inflammation occurs. The inflammatory lesion is characterized by infiltration of CD4+ T cells, including clonally expanded Th17 cells.
Abe S, Tsuboi H, Kudo H, Asashima H, Ono Y, Honda F, Takahashi H, Yagishita M, Hagiwara S, Kondo Y, Matsumoto I, Sumida T.   +11 more
europepmc   +4 more sources

Molecular Modeling of the M3 Acetylcholine Muscarinic Receptor and Its Binding Site [PDF]

Journal of Biomedicine and Biotechnology, 2012
The present study reports the results of a combined computational and site mutagenesis study designed to provide new insights into the orthosteric binding site of the human M3 muscarinic acetylcholine receptor. For this purpose a three-dimensional structure of the receptor at atomic resolution was built by homology modeling, using the crystallographic ...
Marlet Martínez‐Archundia, Arnau Cordomí, Pere Garriga, Juan J. Pérez   +3 more
openalex   +4 more sources

Choline Attenuates Cardiac Fibrosis by Inhibiting p38MAPK Signaling Possibly by Acting on M3 Muscarinic Acetylcholine Receptor [PDF]

Frontiers in Pharmacology, 2019
Choline has been reported to produce a variety of cellular functions including cardioprotection via activating M3 muscarinic acetylcholine receptor (M3R) under various insults.
Lihui Zhao, Lihui Zhao, Tingting Chen, Tingting Chen, Pengzhou Hang, Pengzhou Hang, Wen Li, Wen Li, Jing Guo, Jing Guo, Yang Pan, Yang Pan, Jingjing Du, Jingjing Du, Yuyang Zheng, Yuyang Zheng, Zhimin Du, Zhimin Du, Zhimin Du   +18 more
doaj   +2 more sources

Molecular mechanism of muscarinic acetylcholine receptor M3 interaction with Gq

Communications Biology
Muscarinic acetylcholine receptor M3 (M3) and its downstream effector Gq/11 are critical drug development targets due to their involvement in physiopathological processes.
Donghee Ham, Asuka Inoue, Jun Xu, Yang Du, Ka Young Chung   +4 more
doaj   +3 more sources

Beneficial metabolic effects of M3 muscarinic acetylcholine receptor deficiency [PDF]

Cell Metabolism, 2006
SummaryMost animal models of obesity and hyperinsulinemia are associated with increased vagal cholinergic activity. The M3 muscarinic acetylcholine receptor subtype is widely expressed in the brain and peripheral tissues and plays a key role in mediating 
Jou, William, Li, Jian H., Wess, Jürgen, Gautam, Dinesh, Cui, Yinghong, Jeon, Jongrye, Pack, Stephanie, Gavrilova, Oksana   +7 more
core   +3 more sources

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Successful Therapeutic Plasma Exchange Treatment After SARS‐CoV‐2 Infection—A Case Report [PDF]

Clinical Case Reports, Volume 14, Issue 5, May 2026.
This schematic timeline of symptom progression, infectious history, autoantibody dynamics, and therapeutic interventions illustrates the clinical course of our patient with long‐standing ME/CFS, showing initial improvement during Raltegravir therapy, subsequent symptom worsening following SARS‐CoV‐2 infection with rising autoantibody levels, and ...
Georgiana Ciobanu, Norbert Arn
wiley   +2 more sources

Exploring the Antidiarrheal Properties of Papaya Leaf: Insights In Vivo Study in Mice-Model and In Silico Analysis at M3 Muscarinic Acetylcholine Receptor Interaction [PDF]

Scientifica
Diarrhea caused by gut motility involves 5-HT3 serotonin receptor (5-HT3R) antagonist, M3 muscarinic acetylcholine receptor (M3-AchR), and H1 histamine receptor (H1R) via their respective agonist.
Nyi Mekar Saptarini, Faruk Jayanto Kelutur, Mary Jho-Anne Tolentino Corpuz   +2 more
doaj   +2 more sources

Effect of M3 muscarinic acetylcholine receptor deficiency on collagen antibody-induced arthritis. [PDF]

Arthritis Res Ther, 2016
Background: There is increasing evidence that the non-neuronal cholinergic system might be of importance for the pathology of rheumatoid arthritis. The role of M3 muscarinic acetylcholine receptor (M3R) in this regard has, however, not been investigated to date.
Beckmann J, Dittmann N, Schütz I, Klein J, Lips KS.   +4 more
europepmc   +7 more sources