Results 151 to 160 of about 28,480 (301)

Calcium Mobilization by Activation of M3/M5 Muscarinic Receptors in the Human Retinoblastoma

Journal of Pharmacological Sciences, 2007
Activation of muscarinic acetylcholine receptors (mAChR) is one of the most important signal transduction pathways in the human body. In this study, we investigated the role of mAChR activation in relation to its subtypes in human retinoblastoma cell ...
Dae-Ran Kim, Sang Hoon Rah, Joon Hyung Sohn, Byung-Il Yeh, Chang Mann Ko, Jeong Sook Park, Min-Jeong Kim, Joong Woo Lee, In Deok Kong   +8 more
doaj  

Muscarinic Acetylcholine Receptor M3 Expression and Survival in Human Colorectal Carcinoma-An Unexpected Correlation to Guide Future Treatment? [PDF]

Int J Mol Sci, 2023
Lobbes LA, Schütze MA, Droeser R, Arndt M, Pozios I, Lauscher JC, Hering NA, Weixler B.   +7 more
europepmc   +1 more source

New and developing non-adrenoreceptor small molecule drugs for the treatment of asthma [PDF]

, 2017
Introduction: Inhaled corticosteroids (ICS) alone or in combination with an inhaled long-acting beta2-agonist (LABA) are the preferred long-term treatment for adults and adolescents with symptomatic asthma.
Thomson, Neil C.
core   +1 more source

Modulation of c-Jun NH2-Terminal (JNK) by Cholinergic Autoantibodies from Patients with Sjögren’s Syndrome [PDF]

, 2011
Background: We wanted to determine (via an immunopharmacological approach) whether the c-Jun NH2 terminal kinase (JNK) cascade is phosphorylated in the submandibular gland by carbachol and cholinergic autoantibodies (IgG) present in the sera of patients ...
Borda, Enri Santiago, Passafaro, Daniela, Reina, Silvia, Sterin Borda, Leonor   +3 more
core   +1 more source

Chronic exposure to the anti-M3 muscarinic acetylcholine receptor autoantibody in pemphigus vulgaris contributes to disease pathophysiology [PDF]

, 2022
Alex I. Chernyavsky, Mykhailo M. Khylynskyi, Krupa G. Patel, Sergei A. Grando   +3 more
openalex   +1 more source

The Lower Urinary Tract Science Group Abstracts—ICI‐RS 2024

Neurourology and Urodynamics, Volume 44, Issue 3, Page 691-697, March 2025.
Christopher H. Fry, Andrew Gammie, Bahareh Vahabi, Faezeh A. Hassani, Karen D. McCloskey, Mathijs M. de Rijk, Pradeep Tyagi, Hikaru Hashitani, Michael Winder, Patrik Aronsson, Basu Chakrabarty   +10 more
wiley   +1 more source

Associations of genetic variations in the M3 receptor with salt sensitivity, longitudinal changes in blood pressure and the incidence of hypertension in Chinese adults

The Journal of Clinical Hypertension
Recent studies have reported the role of the M3 muscarinic acetylcholine receptor (M3R), a member of the G‐protein coupled receptor superfamily, encoded by the CHRM3 gene, in cardiac function and the regulation of blood pressure (BP).
Xi Zhang, Shi Yao, Peng Bao, Mingfei Du, Guilin Hu, Chao Chu, Dan Wang, Chen Chen, Qiong Ma, Hao Jia, Yue Sun, Yu Yan, Yueyuan Liao, Zejiaxin Niu, Ziyue Man, Lan Wang, Weihua Gao, Hao Li, Jie Zhang, Wenjing Luo, Xin Wang, Yang Wang, Jianjun Mu   +22 more
doaj   +1 more source

Tiotropium suppresses acetylcholine-induced release of chemotactic mediators in vitro [PDF]

, 2007
SummaryThe driving force in the progression of COPD is the development of exacerbations which are mostly the result of excessive inflammation. Bronchodilatators play an important role in the treatment of COPD. The reported reduction in exacerbation rates
Bühling, Frank, Kühlmann, Ulrike C., Lieder, Nadine, Waldburg, Nadine, Welte, Tobias   +4 more
core   +1 more source

Systems level circuit model of C. elegans undulatory locomotion: mathematical modeling and molecular genetics [PDF]

Journal of Computational Neuroscience 24, 253-276 (2008), 2007
To establish the relationship between locomotory behavior and dynamics of neural circuits in the nematode C. elegans we combined molecular and theoretical approaches. In particular, we quantitatively analyzed the motion of C. elegans with defective synaptic GABA and acetylcholine transmission, defective muscle calcium signaling, and defective muscles ...
arxiv  

P2Y2 Purinergic and M3 Muscarinic Acetylcholine Receptors Activate Different Phospholipase C-β Isoforms That Are Uniquely Susceptible to Protein Kinase C-dependent Phosphorylation and Inactivation [PDF]

, 2000
Derek Strassheim, Carol L. Williams
openalex   +1 more source