Ligand-Induced Activation of the M3-Muscarinic Acetylcholine Receptor
This thesis explores the computer-aided drug design of the M3-muscarinic acetylcholine receptor in three chapters. The first chapter focuses on molecular docking to identify novel agonists using the ZINC12 library. A model of the M3 receptor was built based on the M2 receptor.
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Inhaled glycopyrrolate for the treatment of chronic obstructive pulmonary disease
International Journal of COPD, 2018 Donald P Tashkin,1 Nicholas J Gross2 1Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; 2Department of Medicine, University Medical Research LLC, Saint Francis Hospital and Medical Center, Hartford, CT, USA Abstract:
Tashkin DP, Gross NJ
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Rapid and Persistent Desensitization of m3 Muscarinic Acetylcholine Receptor-stimulated Phospholipase D [PDF]
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Muscarinic acetylcholine receptor M3 modulates odorant receptor activity via inhibition of β-arrestin-2 recruitment. [PDF]
Nat Commun, 2015 Jiang Y +4 more
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Modulation of lower urinary tract smooth muscle contraction and relaxation by the urothelium [PDF]
, 2018 Chess-Williams, Russ +2 more
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Xanomeline/trospium-induced polyuria: A patient case report. [PDF]
Ment Health ClinLeach H, DiGuglielmo F.
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Regulation of acetylcholine release from guinea-pig bladder urothelial cells - potential role in bladder filling sensations [PDF]
, 2014 Fry, C. H. +2 more
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Physiological Significance of Endothelial M3 Muscarinic Receptors During Exercise. [PDF]
Circ ResAckland GL +12 more
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The Activation of Rac1 by M3 Muscarinic Acetylcholine Receptors Involves the Translocation of Rac1 and IQGAP1 to Cell Junctions and Changes in the Composition of Protein Complexes Containing Rac1, IQGAP1, and Actin [PDF]
, 2002 Rebecca Ruiz-Velasco +2 more
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