Results 171 to 180 of about 28,480 (301)

Random Mutagenesis of the M3 Muscarinic Acetylcholine Receptor Expressed in Yeast [PDF]

, 2004
Bo Li, Nicola M. Nowak, Soo‐Kyung Kim, Kenneth A. Jacobson, Ali Bagheri, Clarice Schmidt, Jürgen Wess   +6 more
openalex   +1 more source

Bis-Quinolinium Cyclophane Blockers of SK Potassium Channels Are Antagonists of M3 Muscarinic Acetylcholine Receptors [PDF]

, 2020
Vladislav Bugay, Derek Wallace, Bin Wang, Irving Salinas, Adriana Paola Chapparo, Hudson R. Smith, Peter H. Dube, Edward G. Brooks, Kelly A. Berg, Robert Brenner   +9 more
openalex   +1 more source

Acetylcholine induces fibrogenic effects via M2/M3 ACh receptors in NASH and in primary human hepatic stellate cells [PDF]

, 2016
BACKGROUND: The parasympathetic nervous system (PNS), via neurotransmitter Acetylcholine (ACh), modulates fibrogenesis in animal models. However, the role of ACh in human hepatic fibrogenesis is unclear.
Cordero, P, McKee, C, Morgan, ML, Mouraliderane, A, Nguyen, V, Oben, JA, Sigala, B, Soeda, J, Vinciguerra, M   +8 more
core  

Identification and Structural Determination of the M3 Muscarinic Acetylcholine Receptor Basolateral Sorting Signal [PDF]

, 2005
Heidi A. Iverson, David Fox, Laurie S. Nadler, Rachel E. Klevit, Neil M. Nathanson   +4 more
openalex   +1 more source

Regulation of Src family kinases by muscarinic acetylcholine receptors in heterologous cells and neurons

Frontiers in Molecular Neuroscience
Five muscarinic acetylcholine (mACh) receptor subtypes are divided into two classes: the M1 class (M1, M3, and M5) and the M2 class (M2 and M4). The former is coupled to Gq proteins, while the latter is coupled to Gi/o proteins.
Li-Min Mao, Lexi Young, Xiang-Ping Chu, John Q. Wang, John Q. Wang   +4 more
doaj   +1 more source

Pronounced Conformational Changes following Agonist Activation of the M3 Muscarinic Acetylcholine Receptor [PDF]

, 2005
Sung‐Jun Han, Fadi F. Hamdan, Soo‐Kyung Kim, Kenneth A. Jacobson, Lars Brichta, Lanh M. Bloodworth, Jian H. Li, Jürgen Wess   +7 more
openalex   +1 more source

M3 Muscarinic Receptor Antagonists Inhibit Small Cell Lung Carcinoma Growth and Mitogen-Activated Protein Kinase Phosphorylation Induced by Acetylcholine Secretion [PDF]

, 2007
Pingfang Song, Harmanjatinder S. Sekhon, Allison Lu, Juan Arredondo, David Sauer, Courtney Gravett, Gregory P. Mark, Sergei A. Grando, Eliot R. Spindel   +8 more
openalex   +1 more source

Mogrol stimulates G-protein-coupled bile acid receptor 1 (GPBAR1/TGR5) and insulin secretion from pancreatic β-cells and alleviates hyperglycemia in mice

Scientific Reports
Target identification is a crucial step in elucidating the mechanisms by which functional food components exert their functions. Here, we identified the G-protein-coupled bile acid receptor 1 (GPBAR1, also known as TGR5) as a target of the triterpenoid ...
Chisato Tanaka, Naoki Harada, Yoshiaki Teraoka, Hiroki Urushizaki, Yoh Shinmori, Teruaki Onishi, Yusuke Yotsumoto, Yuta Ito, Tomoya Kitakaze, Takashi Inui, Yuji Murata, Hiroshi Inui, Ryoichi Yamaji   +12 more
doaj   +1 more source

Predicting Novel Functional Roles of Designed Small Biomolecules: An ML Approach Utilizing PubChem Compound and Substance Identifiers (CID-SID ML model) [PDF]

arXiv
Significance and Object: The proposed methodology aims to provide time- and cost-effective approach for the early stage in drug discovery. The machine learning models developed in this study used only the identification numbers provided by PubChem.
arxiv  

The substrate of the biopsychosocial influences in the carcinogenesis of the digestive tract [PDF]

, 2016
Digestive cancer represents a severe public health problem, being one of the main causes of death. It is considered a multifactorial disease, with hereditary predisposition, environmental factors, and other factors involved in carcinogenesis.
Caragea, Daniel, Florescu, Cristina, Pirici, Daniel, Târtea, Elena A, Târtea, Georgică C, Vere, Cristin C   +5 more
core   +2 more sources