Herbal Amara extract induces gastric fundus relaxation via inhibition of the M2 muscarinic receptor. [PDF]
Piqué-Borràs MR, Röhrl J, Künstle G.
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Myelin dysfunction in aging and brain disorders: mechanisms and therapeutic opportunities. [PDF]
Huang Z +4 more
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Inhibitory effect of Zhujing Pill on myopia progression: Mechanistic insights based on metabonomics and network pharmacology. [PDF]
Du Y +12 more
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Epithelial genetic muscarinic receptor 3 ablation induces sex-specific modulation of colonic intestinal progenitor cells and response to intestinal injury. [PDF]
Ragab M +15 more
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m3 Muscarinic Acetylcholine Receptor Regulation in the Airway
American Journal of Respiratory Cell and Molecular Biology, 2002The m3 muscarinic acetylcholine receptor (m3 mAChR) plays an important role in airway function by mediating the effects of acetylcholine on multiple airway cell types. m3 mAChRs expressed in airway smooth muscle (ASM) cells promote increased ASM tension, and, therefore, airway narrowing, in response to acetylcholine release from postganglionic ...
Charlotte K. Billington, Raymond B. Penn
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Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean
Nature, 2001Members of the muscarinic acetylcholine receptor family (M1-M5) have central roles in the regulation of many fundamental physiological functions. Identifying the specific receptor subtype(s) that mediate the diverse muscarinic actions of acetylcholine is of considerable therapeutic interest, but has proved difficult primarily because of a lack of ...
Chieh J. Chou +13 more
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The endegenous muscarinic acetylcholine receptor in Xenopus oocytes is of the M3 subtype
European Journal of Pharmacology, 1988The muscarinic acetylcholine receptor of the Xenopus oocyte was characterized electrophysiologically. Iontophoretic responses to acetylcholine were inhibited by the muscarinic antagonists 4-DAMP, pirenzepine and AF-DX 116 at respective IC50 values of 7 nM, 15 microM and 2 microM.
Lambertus A.C.M. Van Wezenbeek +2 more
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Anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sjögren’s syndrome
Modern Rheumatology, 2012Sjögren's syndrome (SS) is an autoimmune disease that affects exocrine glands including salivary and lacrimal glands. Recently, autoantibodies against muscarinic acetylcholine receptor M3 (M3R) have been detected in serum from 9 to 100 % of patients with SS in addition to anti-SS-A and anti-SS-B antibodies.
Hiromitsu Asashima +4 more
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