Results 211 to 220 of about 13,248 (251)

Atropine can induce autophagy independent of the M3 muscarinic acetylcholine receptor

Haichang Yin, Wen-Zhu Zhuang, Xin-Jie Jiang, Di Liu   +3 more
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Circulating Autoantibodies Against Vasoactive Biomarkers Related to Orthostatic Intolerance in Long COVID Patients Compared to No-Long-COVID Populations: A Case-Control Study. [PDF]

Biomolecules
Han E, Müller-Zlabinger K, Hasimbegovic E, Poschenreithner L, Kastner N, Maleiner B, Hamzaraj K, Spannbauer A, Riesenhuber M, Vavrikova A, Domanig A, Nitsche C, Lukovic D, Zelniker TA, Gyöngyösi M.   +14 more
europepmc   +1 more source

Cholinergic Neuronal Activity Promotes Diffuse Midline Glioma Growth through Muscarinic Signaling

Drexler R, Drinnenberg A, Gavish A, Yalcin B, Shamardani K, Rogers A, Mancusi R, Taylor KR, Kim YS, Woo PJ, Ravel A, Tatlock E, Ramakrishnan C, Ayala-Sarmiento AE, Rincon Fernandez Pacheco D, Siverts L, Daigle TL, Tasic B, Zeng H, Breunig JJ, Deisseroth K, Monje M.   +21 more
europepmc   +1 more source

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m3 Muscarinic Acetylcholine Receptor Regulation in the Airway

American Journal of Respiratory Cell and Molecular Biology, 2002
The m3 muscarinic acetylcholine receptor (m3 mAChR) plays an important role in airway function by mediating the effects of acetylcholine on multiple airway cell types. m3 mAChRs expressed in airway smooth muscle (ASM) cells promote increased ASM tension, and, therefore, airway narrowing, in response to acetylcholine release from postganglionic ...
Charlotte K. Billington, Raymond B. Penn
openaire   +2 more sources

Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean

Nature, 2001
Members of the muscarinic acetylcholine receptor family (M1-M5) have central roles in the regulation of many fundamental physiological functions. Identifying the specific receptor subtype(s) that mediate the diverse muscarinic actions of acetylcholine is of considerable therapeutic interest, but has proved difficult primarily because of a lack of ...
Chieh J. Chou, Toru Moriguchi, Masahisa Yamada, Alokesh Duttaroy, Bing Xia, Ryosuke Makita, Tsuyoshi Miyakawa, Tsuyoshi Miyakawa, Akihiro Yamanaka, Jacqueline N. Crawley, Christian C. Felder, Masaharu Ogawa, Chu-Xia Deng, Jürgen Wess   +13 more
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The endegenous muscarinic acetylcholine receptor in Xenopus oocytes is of the M3 subtype

European Journal of Pharmacology, 1988
The muscarinic acetylcholine receptor of the Xenopus oocyte was characterized electrophysiologically. Iontophoretic responses to acetylcholine were inhibited by the muscarinic antagonists 4-DAMP, pirenzepine and AF-DX 116 at respective IC50 values of 7 nM, 15 microM and 2 microM.
Lambertus A.C.M. Van Wezenbeek, Gé S.F. Ruigt, Jeroen A.D.M. Tonnaer   +2 more
openaire   +3 more sources

Anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sjögren’s syndrome

Modern Rheumatology, 2012
Sjögren's syndrome (SS) is an autoimmune disease that affects exocrine glands including salivary and lacrimal glands. Recently, autoantibodies against muscarinic acetylcholine receptor M3 (M3R) have been detected in serum from 9 to 100 % of patients with SS in addition to anti-SS-A and anti-SS-B antibodies.
Hiromitsu Asashima, Mana Iizuka, Isao Matsumoto, Hiroto Tsuboi, Takayuki Sumida   +4 more
openaire   +3 more sources

Muscarinic acetylcholine receptor M3 in proliferation and perineural invasion of cholangiocarcinoma cells

Hepatobiliary & Pancreatic Diseases International, 2012
Cholangiocarcinoma, a type of malignant tumor, originates from epithelial cells of the bile duct. Perineural invasion is common path for cholangiocarcinoma metastasis, and it is highly correlated with postoperative recurrence and poor prognosis. It has been reported that muscarinic acetylcholine receptor M3 (mAChR M3) is widely expressed in digestive ...
Ru-Yong Yao, Yun Lu, Yujie Feng, Bing-Yuan Zhang   +3 more
openaire   +3 more sources

Determination of Region-Specific Roles of the M3 Muscarinic Acetylcholine Receptor in Gastrointestinal Motility

Digestive Diseases and Sciences, 2022
The specific role of the M3 muscarinic acetylcholine receptor in gastrointestinal motility under physiological conditions is unclear, due to a lack of subtype-selective compounds.The objective of this study was to determine the region-specific role of the M3 receptor in gastrointestinal motility.We developed a novel positive allosteric modulator (PAM ...
Yoko Igarashi-Hisayoshi, Eikichi Ihara, Xiaopeng Bai, Chika Higashi, Hiroko Ikeda, Yoshimasa Tanaka, Mayumi Hirano, Haruei Ogino, Takatoshi Chinen, Yasushi Taguchi, Yoshihiro Ogawa   +10 more
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Cloning and expression of a cDNA encoding bovine muscarinic acetylcholine m3 receptor

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1994
A cDNA clone encoding bovine muscarinic acetylcholine m3 receptor has been isolated from a bovine brain library. Sequencing of this clone has revealed a single open reading frame encoding a protein of 590 amino acids. Comparison with known muscarinic m3 receptor sequences from other species shows a high degree of conservation (92-98% homology) in the ...
Paula K. Hodges, Fraser Glickman, Kwen-Jen Chang, Paul H.K. Lee   +3 more
openaire   +3 more sources