Results 231 to 240 of about 13,541 (253)

Cloning and expression of a cDNA encoding bovine muscarinic acetylcholine m3 receptor

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1994
A cDNA clone encoding bovine muscarinic acetylcholine m3 receptor has been isolated from a bovine brain library. Sequencing of this clone has revealed a single open reading frame encoding a protein of 590 amino acids. Comparison with known muscarinic m3 receptor sequences from other species shows a high degree of conservation (92-98% homology) in the ...
P H, Lee, P K, Hodges, F, Glickman, K J, Chang   +3 more
openaire   +2 more sources

M3 muscarinic acetylcholine receptor antagonists: SAR and optimization of bi-aryl amines

Bioorganic & Medicinal Chemistry Letters, 2009
Exploration of multiple regions of a bi-aryl amine template led to the identification of highly potent M(3) muscarinic acetylcholine receptor antagonists such as 14 (pA(2)=11.0) possessing good sub-type selectivity for M(3) over M(2). The structure-activity relationships (SAR) and optimization of the bi-aryl amine series are described.
Brian, Budzik, Yonghui, Wang, Dongchuan, Shi, Feng, Wang, Haibo, Xie, Zehong, Wan, Chongye, Zhu, James J, Foley, Parvathi, Nuthulaganti, Lorena A, Kallal, Henry M, Sarau, Dwight M, Morrow, Michael L, Moore, Ralph A, Rivero, Michael, Palovich, Michael, Salmon, Kristen E, Belmonte, Dramane I, Laine, Jian, Jin   +18 more
openaire   +2 more sources

Muscarinic acetylcholine receptor M3 in proliferation and perineural invasion of cholangiocarcinoma cells

Hepatobiliary & Pancreatic Diseases International, 2012
Cholangiocarcinoma, a type of malignant tumor, originates from epithelial cells of the bile duct. Perineural invasion is common path for cholangiocarcinoma metastasis, and it is highly correlated with postoperative recurrence and poor prognosis. It has been reported that muscarinic acetylcholine receptor M3 (mAChR M3) is widely expressed in digestive ...
Yu-Jie, Feng, Bing-Yuan, Zhang, Ru-Yong, Yao, Yun, Lu   +3 more
openaire   +2 more sources

M1-M3 muscarinic acetylcholine receptor-deficient mice: novel phenotypes.

Journal of molecular neuroscience : MN, 2007
The five muscarinic acetylcholine receptors (M1-M5 mAChRs) mediate a very large number of important physiological functions (Caulfield, 1993; Caulfield and Birdsall, 1998; Wess, 2004). Because of the lack of small molecule ligands endowed with a high degree of receptor subtype selectivity and the fact that most tissues or cell types express two or more
Dinesh, Gautam, Alokesh, Duttaroy, Yinghong, Cui, Sung-Jun, Han, Chuxia, Deng, Thomas, Seeger, Christian, Alzheimer, Jürgen, Wess   +7 more
openaire   +1 more source

Novel selective M3 muscarinic acetylcholine receptor ligands: Design, synthesis, and characterization

2022
Asthma and COPD are the most prevalent obstructive lung diseases worldwide and are associated with chronic airflow restriction. In the respiratory tract, smooth muscle tone is predominantly dependent on cholinergic activation of the Gq-coupled M3 muscarinic acetylcholine receptor (mAChR).
openaire   +1 more source

M3 muscarinic acetylcholine receptor in cardiology and oncology

International Journal of Cardiology, 2014
openaire   +2 more sources

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly  

From structure to clinic: Design of a muscarinic M1 receptor agonist with the potential to treat Alzheimer’s disease

Cell, 2021
Sophie J Bradley, Kirstie Bennett, Chris De Graaf   +2 more
exaly  

Muscarinic acetylcholine receptors: novel opportunities for drug development

Nature Reviews Drug Discovery, 2014
Andrew C Kruse, Brian K Kobilka, Dinesh Gautam   +2 more
exaly  

M3 Muscarinic Acetylcholine Receptor

2007
openaire   +1 more source