Muscarinic receptor M3 contributes to intestinal stem cell maintenance via EphB/ephrin-B signaling
Life Science Alliance, 2021 A signaling cascade composing M3, EphB/ephrin-B, and MEK synergizes to guide the homeostasis of intestinal epithelial cell growth and differentiation following modifications of the cholinergic intestinal niche.
Toshio Takahashi +6 more
semanticscholar +1 more source
Elevated Hippocampal Cholinergic Neurostimulating Peptide precursor protein (HCNP-pp) mRNA in the amygdala in major depression [PDF]
, 2015 The amygdala is innervated by the cholinergic system and is involved in major depressive disorder (MDD). Evidence suggests a hyper-activate cholinergic system in MDD.
Argibay, Pablo +3 more
core +1 more source
Investigation of M3 Muscarinic Acetylcholine Receptor Expression in Placentas of Smoking Women
Perinatal JournalObjective: This study examined M3 muscarinic acetylcholine receptor expression in placentas of women who smoked during pregnancy and explored the affected signaling pathways via network and functional annotation analyses. Methods: Placenta samples from 45 control subjects and 45 individuals who smoked during pregnancy were fixed in zinc-formalin and em-
Esma Yıldırım +6 more
openalex +2 more sources
Anti-M3 muscarinic acetylcholine receptor antibodies and Sjögren's syndrome
Japanese Journal of Clinical Immunology, 2013 Sjögren's syndrome (SS) is an autoimmune disease that affects exocrine glands including salivary and lacrimal glands. It is characterized by lymphocytic infiltration into exocrine glands, leading to dry mouth and eyes. A number of auto-antibodies are detected in patients with SS. However, no SS-specific pathologic auto-antibodies have yet been found in
Hiroto, Tsuboi +3 more
openaire +3 more sources
Identification and Role of Muscarinic Receptor Subtypes Expressed in Rat Adrenal Medullary Cells
Journal of Pharmacological Sciences, 2011 .: The muscarinic receptor is known to be involved in the acetylcholine (ACh)-induced secretion of catecholamines in the adrenal medullary (AM) cells of various mammals.
Keita Harada +4 more
doaj +1 more source
Thymol as a Potential Natural Antiemetic: Insights From In Vivo and In Silico Studies. [PDF]
Food Sci NutrAccording to the study, thymol (THY) greatly decreased retches and enhanced latency in a model of chick emesis; the highest effectiveness was shown at 20 mg/kg. According to molecular docking, THY binds strongly to important emetic receptors (5‐HT3A, D2, M3, and H1), indicating a multi‐target mechanism.
Akbor S +11 more
europepmc +2 more sources
Generation of Choline for Acetylcholine Synthesis by Phospholipase D Isoforms [PDF]
, 2001 DEDICATION: This article is dedicated to the memory of Sue Kim Hanson, a graduate student in the department of Pathology and Laboratory Medicine at Boston University School of Medicine, who perished in the terrorist attacks of September 11, 2001 ...
Blusztajn, Jan Krzysztof +2 more
core +3 more sources
Enteric dysfunctions in experimental Parkinson's disease: alterations of excitatory cholinergic neurotransmission regulating colonic motility in rats [PDF]
, 2016 Parkinson's disease (PD) is frequently associated with gastrointestinal symptoms, mostly represented by constipation and defecatory dysfunctions.
Al Harraq, Zainab +14 more
core +1 more source
Bioengineered, 2022 Hederagenin (HE) plays a protective role by inhibiting cell proliferation and ameliorating fibrosis. The current therapy for Chronic kidney disease (CKD) often result in the risks of side effects. The present study aimed to explore whether it can protect
Wei Yang, Lijuan He
semanticscholar +1 more source
Carbachol increases intracellular free calcium concentrations in human granulosa-lutein cells [PDF]
, 1992 We investigated whether the stimulation of human granulosa-lutein cells with muscarinic and nicotinic receptor agonists can cause increases in intracellular free calcium (Ca2+), using Fura-2 microfluorimetry.
Föhr, K. J. +3 more
core +1 more source