Results 61 to 70 of about 28,480 (301)

The protective effect of hederagenin on renal fibrosis by targeting muscarinic acetylcholine receptor

Bioengineered, 2022
Hederagenin (HE) plays a protective role by inhibiting cell proliferation and ameliorating fibrosis. The current therapy for Chronic kidney disease (CKD) often result in the risks of side effects. The present study aimed to explore whether it can protect
Wei Yang, Lijuan He
semanticscholar   +1 more source

Critical metabolic roles of β-cell M3 muscarinic acetylcholine receptors [PDF]

Life Sciences, 2012
Muscarinic acetylcholine (ACh) receptors (mAChRs; M(1)-M(5)) regulate the activity of an extraordinarily large number of important physiological processes. We and others previously demonstrated that pancreatic β-cells are endowed with M(3) mAChRs which are linked to G proteins of the G(q) family.
Jürgen Wess, Dinesh Gautam, Jean-Marc Guettier, Shalini Jain, Inigo Ruiz de Azua   +4 more
openaire   +3 more sources

Metformin Improves Autonomic Nervous System Imbalance and Metabolic Dysfunction in Monosodium L-Glutamate-Treated Rats

Frontiers in Endocrinology, 2021
Metformin is an antidiabetic drug used for the treatment of diabetes and metabolic diseases. Imbalance in the autonomic nervous system (ANS) is associated with metabolic diseases.
Claudinéia Conationi da Silva Franco, Carina Previate, Amanda Bianchi Trombini, Rosiane Aparecida Miranda, Luiz Felipe Barella, Lucas Paulo Jacinto Saavedra, Júlio Cezar de Oliveira, Kelly Valério Prates, Laize Peron Tófolo, Tatiane Aparecida Ribeiro, Audrei Pavanello, Ananda Malta, Isabela Peixoto Martins, Veridiana Motta Moreira, Camila Cristina Ianoni Matiusso, Flávio Andrade Francisco, Vander Silva Alves, Ana Maria Praxedes de Moraes, Juliane Rocha de Sant Anna, Marialba Avezum Alves de Castro Prado, Rodrigo Mello Gomes, Elaine Vieira, Paulo Cezar de Freitas Mathias   +22 more
doaj   +1 more source

A Hydrophobic Gate in an Ion Channel: The Closed State of the Nicotinic Acetylcholine Receptor [PDF]

Physical Biology, 3(2):147-159, 2006, 2005
The nicotinic acetylcholine receptor (nAChR) is the prototypic member of the `Cys-loop' superfamily of ligand-gated ion channels which mediate synaptic neurotransmission, and whose other members include receptors for glycine, gamma-aminobutyric acid, and serotonin.
arxiv   +1 more source

Spatial intensity distribution analysis: studies of G Protein-coupled receptor oligomerization [PDF]

, 2018
Spatial intensity distribution analysis (SpIDA) is a recently developed approach for determining quaternary structure information on fluorophore-labelled proteins of interest in situ. It can be applied to live or fixed cells and native tissue.
Marsango, Sara, Milligan, Graeme, Pediani, John D., Ward, Richard J.   +3 more
core   +1 more source

Clinical and Preclinical Evidence for M1 Muscarinic Acetylcholine Receptor Potentiation as a Therapeutic Approach for Rett Syndrome

Neurotherapeutics, 2022
Rett syndrome (RTT) is a neurodevelopmental disorder that is characterized by developmental regression, loss of communicative ability, stereotyped hand wringing, cognitive impairment, and central apneas, among many other symptoms.
Mackenzie Smith, Bright Arthur, Jakub J Cikowski, Calista Holt, S. González, Nicole M. Fisher, S. Vermudez, C. Lindsley, C. Niswender, Rocco G. Gogliotti   +9 more
semanticscholar   +1 more source

The M3 Muscarinic Acetylcholine Receptor Can Signal through Multiple G Protein Families. [PDF]

Mol Pharmacol
Smith JS, Hilibrand AS, Skiba MA, Dates AN, Calvillo-Miranda VG, Kruse AC.   +5 more
europepmc   +3 more sources

Activation State of the M3 Muscarinic Acetylcholine Receptor Modulates Mammalian Odorant Receptor Signaling [PDF]

Science Signaling, 2011
Crosstalk between neurotransmitter signaling and odorant signaling may enhance the sense of smell.
Y. R. Li, H. Matsunami
semanticscholar   +3 more sources

Molecular Cloning of m3 Muscarinic Acetylcholine Receptor in Rat Iris.

Journal of Smooth Muscle Research, 1998
Muscarinic receptor subtypes that involved in cholinergic responses in rat iris were identified by reverse transcription-polymerase chain reaction (RT-PCR) analysis. mRNAs encoding m2, m3, and m4 subtypes were abundantly expressed in iris, whereas m1 and m5 subtypes were not detected.
Susumu Ohya, Minoru Watanabe, Yuji Imaizumi, Michino Furuta   +3 more
openaire   +4 more sources

Alpha7 nicotinic acetylcholine receptor signaling modulates ovine fetal brain astrocytes transcriptome in response to endotoxin [PDF]

Front. Immunol. 2019, 2018
Neuroinflammation in utero may result in lifelong neurological disabilities. Astrocytes play a pivotal role, but the mechanisms are poorly understood. No early postnatal treatment strategies exist to enhance neuroprotective potential of astrocytes. We hypothesized that agonism on alpha7 nicotinic acetylcholine receptor (alpha7nAChR) in fetal astrocytes
arxiv   +1 more source