Results 81 to 90 of about 13,541 (253)

New and developing non-adrenoreceptor small molecule drugs for the treatment of asthma [PDF]

, 2017
Introduction: Inhaled corticosteroids (ICS) alone or in combination with an inhaled long-acting beta2-agonist (LABA) are the preferred long-term treatment for adults and adolescents with symptomatic asthma.
Thomson, Neil C.
core   +1 more source

Alterations in histamine responses between juvenile and adult urinary bladder urothelium, lamina propria and detrusor tissues [PDF]

, 2020
Inflammatory mediators may have a role in various lower urinary tract disorders. Histamine is known to induce significant increases in both the tension and frequency of spontaneous phasic contractions in both urothelium with lamina propria (U&LP) and
Chess-Williams, Russ, Moro, Christian, Stromberga, Zane   +2 more
core   +1 more source

Arctic lake trout (Salvelinus namaycush) show evidence of seasonal acclimation of cardiac adrenergic sensitivity but not heat tolerance

Journal of Fish Biology, EarlyView.
Abstract Many Arctic fishes experience prolonged periods of extreme cold and large thermal variation over both rapid and seasonal time scales which challenge critical physiological functions. In the central Canadian Arctic, we caught wild adult lake trout (Salvelinus namaycush) acclimatized to winter and summer temperatures to determine the extent to ...
Emily P. Williams, Les N. Harris, Jean‐Sébastien Moore, Ella K. Middleton, Shira A. Berkelhammer, Ben Speers‐Roesch, Matthew J. H. Gilbert   +6 more
wiley   +1 more source

Electroacupuncture acutely improves cerebral blood flow and attenuates moderate ischemic injury via an endothelial mechanism in mice. [PDF]

PLoS ONE, 2013
Electroacupuncture (EA) is a novel therapy based on traditional acupuncture combined with modern eletrotherapy that is currently being investigated as a treatment for acute ischemic stroke.
Ji Hyun Kim, Kyung Ha Choi, Young Jung Jang, Sun Sik Bae, Byung-Cheul Shin, Byung Tae Choi, Hwa Kyoung Shin   +6 more
doaj   +1 more source

Association Between Cholinesterase Inhibitor‐Overactive Bladder Antimuscarinic Prescribing Cascade and Risk of Delirium and Falls Among Individuals Living With Dementia

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Prescribing cascades occur when cholinesterase inhibitor (ChEI)‐induced urinary incontinence is misinterpreted as a new condition, leading to overactive bladder (OAB) antimuscarinic initiation. We evaluated whether the ChEI‐OAB antimuscarinic prescribing cascade was associated with delirium or falls compared with mirabegron in older
Sarah Beth Tucker, Bryan L. Love, Chijioke M. Okeke, Erin D. Zwick, Chengwen Teng, Jingkai Wei, Ibraheem M. Karaye, Saud Alsahali, Krithika Rajagopalan, Ismaeel Yunusa   +9 more
wiley   +1 more source

Functional M₃ muscarinic acetylcholine receptors in mammalian hearts [PDF]

British Journal of Pharmacology, 2004
In contrast to most peripheral tissues where multiple subtypes of muscarinic acetylcholine receptor (mAChR) coexist, with each of them playing its part in the orchestra of parasympathetic innervation, the myocardium has been traditionally considered to possess a single mAChR subtype.
Zhiguo, Wang, Hong, Shi, Huizhen, Wang
openaire   +2 more sources

Activation of M3 Muscarinic Acetylcholine Receptors Delayed Cardiac Aging by Inhibiting the Caspase-1/IL-1β Signaling Pathway

Cellular Physiology and Biochemistry, 2018
Background/Aims: Because the prevalence of age-related cardiac impairment increases as the human lifespan increases, it is important to combat the effects of aging.
Shu Wang, Yanan Jiang, Jingling Chen, Changliang Dai, Dandan Liu, Wei Pan, Lijuan Wang, Moyondafoluwa Blessing Fasae, Lihua Sun, Lanfeng  Wang, Yan Liu   +10 more
doaj   +1 more source

Autoantibodies against Muscarinic Acetylcholine Receptor on Exocrine Glands in Sjögren Syndrome [PDF]

, 2014
These investigations demonstrate that serum antibodies against muscarinic acetylcholine receptors (mAChR) in primary Sjögren syndrome (pSS) and associated Sjögren syndrome (aSS) bind and activate both cholinergic receptors of M3 in salivary gland and M1 ...
Borda, Enri Santiago, Reina, Silvia Lorena   +1 more
core   +1 more source

Advances in Gene Therapy for Xerostomia: Current Perspectives and Future Directions: A Narrative Review

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Xerostomia, or dry mouth, significantly impairs quality of life and oral health, particularly in patients subjected to radiation therapy or suffering from systemic disorders. This narrative review summarizes the current evidence on the efficacy and safety of gene therapy interventions for xerostomia, exploring innovative ...
Muhammad Usman Bilal, Sarah Alvi, Fatima Humayune, Hasan Mujtaba, Shahzad Ahmad, Shazia Iqbal, Muhammad Farooq Umer   +6 more
wiley   +1 more source

Direct modulation of TRPC ion channels by Gα proteins

Frontiers in Physiology
GPCR-Gi protein pathways are involved in the regulation of vagus muscarinic pathway under physiological conditions and are closely associated with the regulation of internal visceral organs.
Hana Kang, Jinhyeong Kim, Christine Haewon Park, Byeongseok Jeong, Insuk So   +4 more
doaj   +1 more source