Results 61 to 70 of about 6,851 (178)
Effect of M3 muscarinic acetylcholine receptor deficiency on collagen antibody-induced arthritis [PDF]
Arthritis Research & Therapy, 2016 Background: There is increasing evidence that the non-neuronal cholinergic system might be of importance for the pathology of rheumatoid arthritis. The role of M3 muscarinic acetylcholine receptor (M3R) in this regard has, however, not been investigated to date.
Beckmann, Janet +5 more
openaire +5 more sources
Journal of Pharmaceutical Analysis, 2021 Diarrhea is a prevalent gastrointestinal problem associated with fatal implications. It is a huge public health concern that requires better alternatives to current drugs.
Blessing O. Omolaso +5 more
doaj +1 more source
Archiv der Pharmazie, Volume 359, Issue 6, June 2026.Modulation of K2P and Kv7 channels has the potential to reduce hyperexcitability and hypersynchronicity within the thalamocortical system. This offers a new avenue to suppress spike and wave discharges, the electrophysiological hallmark of absence epilepsy.
Anushka Takhi +3 more
wiley +1 more source
AnimalsPhotoperiods are crucial environmental factors in the growth and health of modern intensive broiler chicken production. To date, the effects of different photoperiods on glucose metabolism, acetylcholine (ACh), and its relative acetylcholine receptor ...
Miao Yu +4 more
doaj +1 more source
Influence of nano-TiO2 on functioning of gastric smooth muscles: in vitro and in silico studies
Біологічні студії, 2019 Nanosized materials, including titanium dioxide nanoparticles, sized under 10 nm, are systems with an excessive energy and high chemical activity, while the nanoparticles of about (1–3) nm enter the reactions with other chemical compounds practically ...
O. V. Tsymbalyuk +2 more
doaj +1 more source
PLoS ONE, 2022 Overexpression of M3 subtype muscarinic receptors (M3R) hastens colon cancer progression. As microRNA (miRNA) expression is commonly dysregulated in cancer, we used microarrays to examine miRNA profiles in muscarinic receptor agonist-treated human colon ...
Shannon M Larabee +3 more
doaj +1 more source
Gastric Cancer: Pathobiology and Therapeutics
MedComm, Volume 7, Issue 6, June 2026.Gastric cancer is a multistep process driven by the interplay of microbial virulence, host epithelial injury, and evolving molecular reprogramming. Initiation involves pathogen‐induced epigenetic alterations and the early subversion of key oncogenic signaling networks, facilitating the transition from chronic injury to metaplasia and malignant ...
Ruixian Yu +16 more
wiley +1 more source
Computational Quantification of Peristalsis in Preclinical Mouse Models Using Smartphone Videography
Neurogastroenterology &Motility, Volume 38, Issue 6, June 2026.A new computational method and analytical pipeline for quantifying gut peristalsis in live mouse models that involves taking a video using a smartphone camera and then processing the videographic data using our custom analytical pipeline to quantify gastrointestinal motility.
Joseph C. Schindler +4 more
wiley +1 more source
M3 Muscarinic Acetylcholine Receptor-Mediated Signaling Is Regulated by Distinct Mechanisms
Molecular Pharmacology, 2008 We have used RNA interference previously to demonstrate that G protein-coupled receptor kinase 2 (GRK2) regulates endogenously expressed H1 histamine receptor in human embryonic kidney 293 cells. In this report, we investigate the regulation of endogenously expressed M(3) muscarinic acetylcholine receptor (M(3) mAChR).
Jiansong, Luo +2 more
openaire +3 more sources
Health Science Reports, Volume 9, Issue 5, May 2026.ABSTRACT Background and Aims Xerostomia, or dry mouth, significantly impairs quality of life and oral health, particularly in patients subjected to radiation therapy or suffering from systemic disorders. This narrative review summarizes the current evidence on the efficacy and safety of gene therapy interventions for xerostomia, exploring innovative ...
Muhammad Usman Bilal +6 more
wiley +1 more source