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Molecular Mechanisms of Action of M5 Muscarinic Acetylcholine Receptor Allosteric Modulators [PDF]

open access: closedMolecular Pharmacology, 2016
Recently, the first subtype-selective allosteric modulators of the M5 muscarinic acetylcholine receptor (mAChR) have been described, but their molecular mechanisms of action remain unknown. Using radioligand-binding and functional assays of inositol phosphate (IP) accumulation and Ca(2+) mobilization in a recombinant cell line stably expressing the ...
Alice E. Berizzi   +6 more
  +9 more sources

Activation mechanism of the M5 muscarinic acetylcholine receptor

open access: closedBiophysical Journal, 2023
Lee Roy   +3 more
openalex   +2 more sources

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