Results 101 to 110 of about 897,142 (304)

mTORC2 affects the maintenance of the muscle stem cell pool

Skeletal Muscle, 2019
Background The mammalian target of rapamycin complex 2 (mTORC2), containing the essential protein rictor, regulates cellular metabolism and cytoskeletal organization by phosphorylating protein kinases, such as PKB/Akt, PKC, and SGK.
Nathalie Rion, Perrine Castets, Shuo Lin, Leonie Enderle, Judith R. Reinhard, Markus A. Rüegg   +5 more
doaj   +1 more source

Human laminin-111 and laminin-211 protein therapy prevents muscle disease progression in an immunodeficient mouse model of LAMA2-CMD

Skeletal Muscle, 2020
Background Laminin-α2-related congenital muscular dystrophy (LAMA2-CMD) is a devastating genetic disease caused by mutations in the LAMA2 gene. These mutations result in progressive muscle wasting and inflammation leading to delayed milestones, and ...
Pamela Barraza-Flores, Hailey J. Hermann, Christina R. Bates, Tyler G. Allen, Timothy T. Grunert, Dean J. Burkin   +5 more
doaj   +1 more source

Flux control of cytochrome c oxidase in human skeletal muscle [PDF]

, 2000
In the present work, by titrating cytochrome c oxidase (COX) with the specific inhibitor KCN, the flux control coefficient and the metabolic reserve capacity of COX have been determined in human saponin-permeabilized muscle fibers. In the presence of the
Attardi, Giuseppe, Elger, Christian E., Kudin, Alexei, Kunz, Wolfram S., Vielhaber, Stefan, Villani, Gaetano   +5 more
core   +1 more source

Pain and Patient‐Reported Physical Function Did Not Differ Between Body Composition Profiles in Patients with Hip Osteoarthritis

Arthritis Care &Research, Accepted Article.
Objective To explore whether higher body fat and lower lean mass are associated with greater pain and worse patient‐reported physical function in individuals with hip osteoarthritis (OA). A secondary aim was to examine whether pain and patient‐reported physical function differ according to four body composition profiles: high body fat, low lean mass ...
Alexandra Ryan, Boliang Wang, Fiona Dobson, Ben Kirk, Travis Haber, Kim L. Bennell, Shirley P. Yu, Kim Allison, Ricardo J.S. Costa, Gabrielle Knox, Michelle Hall   +10 more
wiley   +1 more source

Myoblast fusion confusion: the resolution begins

Skeletal Muscle, 2018
The fusion of muscle precursor cells is a required event for proper skeletal muscle development and regeneration. Numerous proteins have been implicated to function in myoblast fusion; however, the majority are expressed in diverse tissues and regulate ...
Srihari C. Sampath, Srinath C. Sampath, Douglas P. Millay   +2 more
doaj   +1 more source

Surgical fatigue syndrome and EDiS3 intervention, should every surgeon need to know how to mitigate muscle skeletal discomfort? [PDF]

Surg Open Sci, 2023
Chávez-Saavedra G, Espinosa-Hinojosa A, Colonna-Márquez LE, Hidalgo-Valadez C, Díaz-Martínez DA, González-Sandoval BV.   +5 more
europepmc   +1 more source

Denervation does not induce muscle atrophy through oxidative stress [PDF]

, 2017
Denervation leads to the activation of the catabolic pathways, such as the ubiquitin-proteasome and autophagy, resulting in skeletal muscle atrophy and weakness.
Adamo, Sergio, Bellezza, Ilaria, Fulle, Stefania, Greco, Emanuela, Grottelli, Silvia, Mancinelli, Rosa, Minelli, Alba, Moresi, Viviana, Morozzi, Giulio, Pigna, Eva, Rotini, Alessio   +10 more
core   +3 more sources

Obesity subtypes and longitudinal trajectories of function over 7‐years of follow‐up: data from the Multicenter Osteoarthritis Study

Arthritis Care &Research, Accepted Article.
Background Obesity, defined by BMI ≥30kg/m2, is a risk factor for functional limitations in people with knee osteoarthritis (OA). However, function varies among such individuals. Our objective was to evaluate the implications of obesity subtypes on longitudinal patterns of physical functioning in people with or at risk for knee OA.
Kristine Godziuk, Sarah Tilley, Michael LaValley, Michael C. Nevitt, Cora E. Lewis, James C. Torner, Tuhina Neogi   +6 more
wiley   +1 more source

Author Correction: Long-term voluntary running prevents the onset of symptomatic Friedreich’s ataxia in mice

Scientific Reports, 2021
Henan Zhao, Bevan M. Lewellen, Rebecca J. Wilson, Di Cui, Joshua C. Drake, Mei Zhang, Zhen Yan   +6 more
doaj   +1 more source

Level of muscle regeneration in limb-girdle muscular dystrophy type 2I relates to genotype and clinical severity

Skeletal Muscle, 2011
Background The balance between muscle regeneration and ongoing degeneration is a relationship that greatly influences the progression of muscular dystrophy.
Krag Thomas O, Hauerslev Simon, Sveen Marie, Schwartz Malene, Vissing John   +4 more
doaj   +1 more source