Results 131 to 140 of about 362,047 (272)

Role of Testosterone Signaling in Microglia: A Potential Role for Sex‐Related Differences in Alzheimer's Disease

Advanced Science, EarlyView.
Testosterone enhances Aβ‐induced autophagy in microglia via the non‐genomic testosterone receptor GPRC6A, promoting Aβ clearance by suppressing ERK phosphorylation and inhibiting mTOR activation. In male 5xFAD mice, testicular removal reduces microglial autophagy and Aβ clearance, which is restored by testosterone.
Haiyan Du, Akiko Mizokami, Junjun Ni, Simeng Zhang, Yosuke Yamawaki, Tomomi Sano, Eijiro Jimi, Isei Tanida, Takashi Kanematsu   +8 more
wiley   +1 more source

LIPUS Promotes Calcium Oscillation and Enhances Calcium Dependent Autophagy of Chondrocytes to Alleviate Osteoarthritis

Advanced Science, EarlyView.
A non‐invasive and safe physical therapy, low‐intensity pulsed ultrasound (LIPUS) can alleviate osteoarthritis. This study dynamically “visualizes” the invisible mechanical stimuli of LIPUS on living chondrocytes by fluorescence imaging technology in the form of calcium oscillations, confirming LIPUS maintains cartilage homeostasis by promoting ...
Mengtong Guan, Xiaoyu Han, Bo Liao, Wang Han, Lin Chen, Bin Zhang, Xiuqin Peng, Yu Tian, Gongyi Xiao, Xinhe Li, Liang Kuang, Ying Zhu, Dingqun Bai   +12 more
wiley   +1 more source

DAPK3 is Essential for DBP‐Induced Autophagy of Mouse Leydig Cells

Advanced Science, EarlyView.
This study has confirmed that death‐associated protein kinase 3 (DAPK3) is essential for dibutyl phthalate (DBP)‐induced autophagy of mouse Leydig cells, and is regulated by both transcription factor specific protein 2 (Sp2) and parkin RBR E3 ubiquitin‐protein ligase (PRKN), and melatonin can alleviate DBP‐induced autophagy of the cells.
Si Yang, Ying Yang, Linlin Xu, Chaoju Hao, Jiaxiang Chen   +4 more
wiley   +1 more source

Microfluidics‐Based Microcarriers for Live‐Cell Delivery

Advanced Science, EarlyView.
In this review, recent advancements in microfluidics‐based microcarriers for live‐cell delivery are highlighted. The structural designs of microfluidic‐derived cell‐laden microcarriers are systematically categorized, emphasizing innovative approaches in the fabrication of microspheres, microfibers, and microneedles.
Zhonglin Fang, Xinyuan Yang, Chong Wang, Luoran Shang   +3 more
wiley   +1 more source

A quantitative analysis of 3D-cell distribution in regenerating muscle-skeletal system with synchrotron X-ray computed microtomography. [PDF]

Sci Rep, 2018
Tesařová M, Mancini L, Simon A, Adameyko I, Kaucká M, Elewa A, Lanzafame G, Zhang Y, Kalasová D, Szarowská B, Zikmund T, Novotná M, Kaiser J.   +12 more
europepmc   +1 more source

Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration

Advanced Science, EarlyView.
The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan, Meiqian Wu, Chaonan Zhu, Hao Yu, Minh Duc Pham, Katharina Bottermann, Yijie Mao, Yue Wang, Mathias Langner, Mirko Peitzsch, Arka Provo Das, Silke Kauferstein, Jonathan Ward, Peter Mirtschink, Andreas Michael Zeiher, Stefanie Dimmeler, Jaya Krishnan   +16 more
wiley   +1 more source

Engineering the Immune Response to Biomaterials

Advanced Science, EarlyView.
This paper reviews immune responses to biomaterials, stages of evolution in relation to managing these responses ranging from preventing to modulating them. It also discusses state‐of‐the‐art strategies to modulate these responses and modes of their delivery.
Abolfazl Salehi Moghaddam, Mehran Bahrami, Einollah Sarikhani, Rumeysa Tutar, Yavuz Nuri Ertas, Faleh Tamimi, Ali Hedayatnia, Clotilde Jugie, Houman Savoji, Asma Talib Qureshi, Muhammad Rizwan, Chima V. Maduka, Nureddin Ashammakhi   +12 more
wiley   +1 more source

The Latest Advances in Mechanically Robust Self‐Healing Polyurea Based on Dynamic Chemistry

Advanced Science, EarlyView.
Solving the contradiction between strength, toughness, and self‐healing properties is extremely important to realize the breakthrough of polyurea applications. This review summarizes and discusses common strategies for the preparation of high‐performance and self‐healing polyurea materials based on dynamic chemistry, providing molecular‐level insights ...
Yujia Hao, Guangming Zhu
wiley   +1 more source

Multimodal Locomotion: Next Generation Aerial–Terrestrial Mobile Robotics

Advanced Intelligent Systems, EarlyView., 2023
Aerial–terrestrial robots can achieve efficient energy consumption and robust environmental interaction by adding morphological features, adapting forms for locomotion transitions, and integrating multiple platforms. This next generation of mobile robots advances real‐world robotic deployment for operations with complex tasks and tackle environments ...
Jane Pauline Ramirez, Salua Hamaza
wiley   +1 more source

Syntaxin 17 Translocation Mediated Mitophagy Switching Drives Hyperglycemia‐Induced Vascular Injury

Advanced Science, EarlyView.
Mitophagy switching drives high‐glucose‐induced vascular endothelial injury. Short‐term high‐glucose exposure upregulates Fis1 expression and enhances Fis1‐TBC1D15 interaction, activating Parkin‐mediated mitophagy. Long‐term high‐glucose exposure reduces Fis1 expression, inhibiting Parkin‐mediated mitophagy and triggering mitophagy switching from ...
Anqi Luo, Rui Wang, Jingwen Gong, Shuting Wang, Chuan Yun, Zongcun Chen, Yanan Jiang, Xiaoquan Liu, Haofu Dai, Haochen Liu, Yunsi Zheng   +10 more
wiley   +1 more source