Results 201 to 210 of about 425,571 (245)

Advancing the Understanding and Treatment of Cancer Cachexia: Mechanisms, Therapeutic Approaches, and Future Opportunities. [PDF]

Cancer Manag Res
Li X, Xu T, Zhou L, Li G, Yuan Y, Song H, Liu C, Liu X.   +7 more
europepmc   +1 more source

Site‐Specific Mitochondrial RNA N1‐Methyladenosine Demethylation via an Engineered MTS‐PUF‐ALKBH3 Fusion Protein

Advanced Science, EarlyView.
A CRISPR‐free mitochondrial RNA m1A demethylation (MRD) editor combining MTS, PUF proteins, and ALKBH3 enables precise m1A removal from mitochondrial mRNA and tRNA, which influences mitochondrial protein levels, cellular proliferation, ATP production, and mitochondrial respiration. Subsequently, in vivo demethylation of the m1A modification is achieved
Xiangrui Li, Deqiang Kong, Hongmei Liu, Jie Yang, Jiale Zhou, Yuqiang Qian, Ding Zhao, Jinze Li, Xinyu Wu, Tao Zhang, Xiaodi Sun, Yang Han, Liangxue Lai, Zhanjun Li   +13 more
wiley   +1 more source

Integrated fibre-specific methylome and proteome profiling of human skeletal muscle across males and females with fibre-type deconvolution. [PDF]

Skelet Muscle
Palmer AS, García-Domínguez E, Taylor MF, Garnham A, Seale K, Steele JR, Lee HC, Schittenhelm RB, Eynon N.   +8 more
europepmc   +1 more source

Mechanical Stretch‐Induced Interlayer Coordination between MMP2 and COL17A1 Exacerbates Regenerative Exhaustion in Skin

Advanced Science, EarlyView.
Regeneration reaches a hidden limit under mechanical stretch. Prolonged tension alters dermal–epidermal communication, exhausting epidermal stem cells via MMP2–COL17A1 signaling. MMP2 inhibition by Marimastat preserves adhesion and regenerative capacity, offering a potential strategy to overcome the inherent boundaries of skin expansion.
Yidan Sun, Qili Qian, Luwen Xu, Bowen Gao, Ting Li, Yin Li, Jiayi Zheng, Qiaoyu Fu, Xi Cheng, Nuo Chen, Sijia Wang, Liang Zhang, Caiyue Liu, Qingfeng Li   +13 more
wiley   +1 more source

The impact of second-generation androgen receptor pathway inhibitors on skeletal muscle morphology and strategies to mitigate their effects in prostate cancer patients. [PDF]

Front Rehabil Sci
Edwards S, Lulic-Kuryllo T, Batra A.
europepmc   +1 more source

Assessment of Lectin Staining Biomarkers using a Murine Model of GNE Myopathy. [PDF]

MicroPubl Biol
Parker O, Woods J, Rothkopf M, Drach D, Wetzel HN, Crowe KE.   +5 more
europepmc   +1 more source

AI-Assistance Body Composition CT at T12 and T4 in Lung Cancer: Diagnosing Sarcopenia, and Its Correlation with Morphofunctional Assessment Techniques. [PDF]

Cancers (Basel)
Montero-Benitez MZ, Carmona-Llanos A, Fernández-Jiménez R, Román-Jobacho A, Gómez-Millán J, Modamio-Molina J, Cabrera-Cesar E, Vegas-Aguilar I, Amaya-Campos MDM, Tinahones FJ, Molina-Montes E, Cayón-Blanco M, García-Almeida JM.   +12 more
europepmc   +1 more source

Radiation-induced impairment of skeletal muscle regeneration. [PDF]

Radiol Oncol
Cemazar M, Jurdana M.
europepmc   +1 more source

Surface electrical impedance myography detects disease in an adult-onset SOD1-G93A zebrafish model of amyotrophic lateral sclerosis. [PDF]

Sci Rep
Rutkove SB, Shah P, Hevenor L, Tiwari G, Patil D, Mourey T, Nagy JA, Nath AK.   +7 more
europepmc   +1 more source

Integrated proteomics and transcriptomics analysis of dynamic changes in muscle fiber types in different regions of porcine skeletal muscle. [PDF]

Adv Biotechnol (Singap)
Feng Z, Wang X, Zhou Q, Liu Y, Xu R, Liang Z, Zhang C, Liu X, Zhao Y, Chen Y, Mo D.   +10 more
europepmc   +1 more source