Results 221 to 230 of about 788,671 (263)
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NFAT Regulation in Smooth Muscle
Trends in Cardiovascular Medicine, 2003First identified in activated T cells, the calcium (Ca2+)-dependent transcription factor, nuclear factor of activated T cells (NFAT), has since been shown to play a role in nonimmune cells, including cells of the cardiovascular system. In arterial smooth muscle, the diverse array of calcium-signaling modalities, the functional interplay between smooth ...
Nelson, Mark +4 more
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Evidence that unphosphorylated smooth muscle myosin supports smooth muscle contraction
Biochemical and Biophysical Research Communications, 1991Unphosphorylated smooth muscle myosin filaments do not disassemble in MgATP, provided that the solution is supplemented either by 25% serum albumin or by 6% polyethylene glycol 6000. These filaments are able to support actomyosin retraction but their ATPase activity is not activated by tropomyosin-decorated F-actin.
Enrico Grazi, Giorgio Trombetta
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Clinics in Chest Medicine, 1986
Contraction of tracheal smooth muscle requires the binding of Ca2+ to calmodulin, which then binds to and activates MLCK. The Ca2+-calmodulin-MLCK complex catalyzes the phosphorylation of myosin, which causes contraction by stimulating actin-activated Mg2+-ATPase activity of myosin.
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Contraction of tracheal smooth muscle requires the binding of Ca2+ to calmodulin, which then binds to and activates MLCK. The Ca2+-calmodulin-MLCK complex catalyzes the phosphorylation of myosin, which causes contraction by stimulating actin-activated Mg2+-ATPase activity of myosin.
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Halothane Increases Smooth Muscle Protein Phosphatase in Airway Smooth Muscle
Anesthesiology, 2001Background Halothane relaxes airway smooth muscle, in part, by decreasing the force produced for a given intracellular [Ca(2+)] (i.e., Ca(2+) sensitivity) during muscarinic stimulation, an effect produced by a decrease in regulatory myosin light-chain (rMLC) phosphorylation.
Keith A. Jones +3 more
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[7] Smooth muscle mitochondria
1979Publisher Summary In contrast with other tissues, such as liver and heart, where the mitochondria are particularly abundant, the bulk of smooth muscle tissue consists of myofibrils and connective tissue with relatively few mitochondria. This and the fact that large amounts of smooth muscle are difficult to obtain routinely have resulted in only a few
B Sloane +3 more
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Airway Smooth Muscle in Asthma
Annual Review of Pathology: Mechanisms of Disease, 2004Airway smooth muscle plays a multifaceted role in the pathogenesis of asthma. We review the current understanding of the contribution of airway myocytes to airway inflammation, airway wall remodeling, and airflow obstruction in this prevalent disease syndrome. Together, these roles make airway smooth muscle an attractive target for asthma therapy.
Julian Solway +3 more
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Calcium sparks in smooth muscle
American Journal of Physiology-Cell Physiology, 2000Local intracellular Ca2+transients, termed Ca2+ sparks, are caused by the coordinated opening of a cluster of ryanodine-sensitive Ca2+ release channels in the sarcoplasmic reticulum of smooth muscle cells. Ca2+ sparks are activated by Ca2+ entry through dihydropyridine-sensitive voltage-dependent Ca2+ channels, although the precise mechanisms of ...
Nelson, MT. +3 more
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Canadian Journal of Biochemistry and Physiology, 1958
The sodium, potassium, chloride, and water concentrations have been analyzed in relatively pure smooth muscles of electrophysiological interest and compared to similar analyses of other muscle types. The smooth muscles analyzed included isolated longitudinal myometrium from the uteri of various species and the taenia coli from guinea pigs and rabbits.
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The sodium, potassium, chloride, and water concentrations have been analyzed in relatively pure smooth muscles of electrophysiological interest and compared to similar analyses of other muscle types. The smooth muscles analyzed included isolated longitudinal myometrium from the uteri of various species and the taenia coli from guinea pigs and rabbits.
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The Contractile Apparatus of Smooth Muscle
1980Publisher Summary This chapter describes the architecture of the contractile apparatus. Smooth muscle cells, when isolated, are generally spindle-like in shape with tapered ends and possess a centrally placed, elongated nucleus. In vivo, where the cells occur in bundles and overlapping layers, they adapt themselves to the contours of the tissue; in
Sobieszek A, Small Jv
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1986
Muscles of inner organs of vertebrates, such as gut, uterus, bronchial tree and blood vessels, are termed “smooth muscles” as they lack ordinary striations. Smooth muscles may be spontaneously active, or they may contract in response to nervous or hormonal stimulation.
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Muscles of inner organs of vertebrates, such as gut, uterus, bronchial tree and blood vessels, are termed “smooth muscles” as they lack ordinary striations. Smooth muscles may be spontaneously active, or they may contract in response to nervous or hormonal stimulation.
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