Results 71 to 80 of about 3,179,601 (345)

The Anatomic Features of Müller’s Muscle: A Histology Study in Chinese

open access: yesPlastic and Reconstructive Surgery, Global Open, 2021
Background:. The purpose of this article is to clarify the character of Müller’s muscle in Chinese specimens. Methods:. Ten upper eyelids of 10 formalin-fixed Chinese cadavers (9 elderly people, from 68 to 86 years of age; 1 male child, 10 years old ...
Minchen Zhang, BS   +5 more
doaj   +1 more source

Unique Contractile and Structural Protein Expression in Dog Ileal Inner Circular Smooth Muscle [PDF]

open access: yes, 2009
This study was designed to test the hypothesis that there is heterogeneous expression of contractile and structural proteins between the smooth muscle cells (SMCs) in the inner and outer circular muscle (ICM and OCM) layers of the ileum ...
Eddinger, Thomas J.
core   +1 more source

MMP-1 activation contributes to airway smooth muscle growth and asthma severity [PDF]

open access: yes, 2016
Introduction: Matrix metalloproteinase-1 and mast cells are present in the airways of people with asthma. We hypothesised that matrix metalloproteinase-1 could be activated by mast cells and increase asthma severity.
Berger P   +16 more
core   +2 more sources

Vanadate and smooth muscles.

open access: yesJapanese Journal of Smooth Muscle Research, 1988
Vanadate is a trace element in biological tissues which has inhibitory actions on various enzymes. It inhibits Na, K-ATPase of smooth muscle membrane. Ca-ATPase and Ca-uptake of membranous systems of smooth muscle cells are also inhibited by vanadate. Vanadate induces contractions in various smooth muscles.
openaire   +4 more sources

Electrophysiology of Syncytial Smooth Muscle [PDF]

open access: yesJournal of Experimental Neuroscience, 2019
As in other excitable tissues, two classes of electrical signals are of fundamental importance to the functioning of smooth muscles: junction potentials, which arise from neurotransmission and represent the initiation of excitation (or in some instances inhibition) of the tissue, and spikes or action potentials, which represent the accomplishment of ...
Rohit Manchanda   +2 more
openaire   +4 more sources

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

open access: yesMolecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski   +19 more
wiley   +1 more source

Smooth muscle cells largely develop independently of functional hemogenic endothelium

open access: yesStem Cell Research, 2014
Vascular smooth muscle cells represent a major component of the cardiovascular system. In vitro studies have shown that FLK1+ cells derived from embryonic stem (ES) cells can differentiate into both endothelial and smooth muscle cells.
Monika Stefanska   +4 more
doaj   +1 more source

Smooth Muscle-Targeted Overexpression of Peroxisome Proliferator Activated Receptor-γ Disrupts Vascular Wall Structure and Function. [PDF]

open access: yesPLoS ONE, 2015
Activation of the nuclear hormone receptor, PPARγ, with pharmacological agonists promotes a contractile vascular smooth muscle cell phenotype and reduces oxidative stress and cell proliferation, particularly under pathological conditions including ...
Jennifer M Kleinhenz   +10 more
doaj   +1 more source

The Atypical Cadherin FAT1 Limits Mitochondrial Respiration and Proliferation of Vascular Smooth Muscle Cells

open access: yesFrontiers in Cardiovascular Medicine, 2022
Smooth muscle cells contribute to cardiovascular disease, the leading cause of death worldwide. The capacity of these cells to undergo phenotypic switching in mature arteries of the systemic circulation underlies their pathogenic role in atherosclerosis ...
Dario F. Riascos-Bernal   +4 more
doaj   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

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