Results 141 to 150 of about 508,818 (314)

Conditioned Media from Mechanically Stimulated Macrophages Upregulate Osteogenic Genes in Human Mesenchymal Stromal Cells

open access: yesAdvanced Healthcare Materials, EarlyView.
Bone fracture healing is a complex, timely orchestrated scenario involving multiple cell types and a plethora of cytokines and regulatory factors. To gain further insight, an in vitro model to a) study macrophage polarization under mechanical load in a fibrin hydrogel and b) subsequently assess the effect of conditioned media derived from macrophages ...
Anne Géraldine Guex   +4 more
wiley   +1 more source

Multifunctional Biomedical Devices with Closed‐Loop Systems for Precision Therapy

open access: yesAdvanced Healthcare Materials, EarlyView.
This review explores two major types of closed‐loop therapeutic systems: self‐sustained and externally triggered. It highlights recent advances in stimuli‐responsive materials, integrated bioelectronics, and data‐driven control strategies, offering insight into emerging strategies for personalized, responsive drug delivery.
Yixuan Leng, Rujie Sun
wiley   +1 more source

Cell Surface Thiol Engineering Mechanoregulates Myogenic Differentiation via the FAK–PI3K–AKT Axis

open access: yesAdvanced Healthcare Materials, EarlyView.
Schematic diagram illustrating how cell surface modification of skeletal muscle progenitor cells through TCEP treatment reveals enhanced cell adhesion, intracellular tension, and myogenesis at 19.66 kPa stiffness, leading to optimal cell fusion. In contrast, no significant changes are observed in the softer (10.61 kPa) or stiffer (49.4 kPa) matrices ...
Juyeon Kim   +10 more
wiley   +1 more source

A Computational Journey Toward an Optimal Design for Metamaterial Epicardial Passive Sleeves

open access: yesAdvanced Healthcare Materials, EarlyView.
Passive epicardial sleeves are evaluated in 3D in‐silico heart models to reveal how sleeve geometry, stiffness, anisotropy, and metamaterial architecture influence cardiac mechanics after myocardial infarction. A continuum‐to‐auxetic design exploration shows that region‐specific mechanical engagement can reduce infarct bulging and modulate torsional ...
Vahid Naeini   +8 more
wiley   +1 more source

Reliability of Eelectromyography of Abdominal Muscles During Abdominal Manoeuvre with and without Pelvic Floor Muscle Contraction

open access: yesJournal of Rehabilitation, 2012
Objective: The purpose of this study was to determine the reliability of electromyography measurements of abdominal muscles activity during different manoeuvres (pelvic floor muscle (PFM) contraction, abdominal hollowing and abdominal bracing with and ...
Motahareh Hashem-Boroujerdi   +3 more
doaj  

Sensitivity to Hand Path Curvature during Reaching [PDF]

open access: yes, 2003
People optimize reaching to make straight and smooth movements. We performed experiments characterizing human sensitivity to hand path deviations from a straight reach. Vision of the arm was blocked.
Lillis, Kyle P., Scheidt, Robert A.
core   +1 more source

C60 fullerene helps restore muscle soleus contraction dynamics after achillotomy-induced atrophy

open access: yesБіологічні студії
Background. The search for new means that would effectively influence the pathological consequences of muscle immobilization is an urgent priority request of modern biomedicine.
Dmytro Nozdrenko   +4 more
doaj   +1 more source

Tapered Pillar Design for High‐Precision Force Readout in Miniaturized Engineered Heart Tissues From Human Pluripotent Stem Cells

open access: yesAdvanced Healthcare Materials, EarlyView.
Engineered heart tissues (EHTs) are a valuable approach in capturing human cardiac physiology and drug responses in vitro. Here, a novel tapered pillar design is developed in an EHT platform to confine tissues in a predefined position‐ at the middle of the pillar height.
Milica Dostanić   +9 more
wiley   +1 more source

Home - About - Disclaimer - Privacy