Results 51 to 60 of about 431,326 (355)

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Multi-scale modeling and simulation of skeletal muscles with different fatigue degrees based on microphysiology

Scientific Reports
The ability for skeletal muscle to constantly generate force is limited by the muscle fatigue. The calcium ion plays a significant role of the cross-bridge cycle under fatigue conditions in the force generation of skeletal muscle.
Monan Wang, Daixin Jin, Haibin Wang, Xinyi Xu, Siyuan Zheng   +4 more
doaj   +1 more source

Knee joint neuromuscular activation performance during muscle damage and superimposed fatigue [PDF]

, 2012
This study examined the concurrent effects of exercise-induced muscle damage and superimposed acute fatigue on the neuromuscular activation performance of the knee flexors of nine males (age: 26.7 ± 6.1yrs; height 1.81 ± 0.05m; body mass 81.2 ± 11.7kg ...
Behm D. G., Brockett C. L., Claire Minshull, David Rees, Enoka R. M., Foley J. M., Gleeson N. P., Hopkins J. T, Hortobagyi T., Morgan D. L., Nigel Gleeson, Roger Eston, Saxton J. M.   +12 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Exploration and Application of a Muscle Fatigue Assessment Model Based on NMF for Multi-Muscle Synergistic Movements

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Muscle fatigue significantly impacts coordination, stability, and speed in daily activities. Accurate assessment of muscle fatigue is vital for effective exercise programs, injury prevention, and sports performance enhancement.
Jinxu Yu, Lijie Zhang, Yihao Du, Xiaoran Wang, Jianhua Yan, Jie Chen, Ping Xie   +6 more
doaj   +1 more source

Sex Differences in Fatigability of Dynamic Contractions [PDF]

, 2016
Women are usually less fatigable than men during single-limb isometric contractions, primarily because of sex-related differences in contractile mechanisms.
Hunter, Sandra K.
core   +1 more source

Muscle Fatigue Analysis Using OpenSim

, 2017
In this research, attempts are made to conduct concrete muscle fatigue analysis of arbitrary motions on OpenSim, a digital human modeling platform. A plug-in is written on the base of a muscle fatigue model, which makes it possible to calculate the ...
B Bigland-Ritchie, DB Chaffin, DB Chaffin, DG Thelen, FE Zajac, JA Kent-Braun, JM Winters, JR Fuller, L Ma, L Ma, L Ma, L Ma, L Ma, M Damsgaard, R Feyen, R Ma, S Sakka, SL Delp, SR Hamner, T Yoon, TJ Armstrong   +20 more
core   +2 more sources

Exercise-induced abdominal muscle fatigue in healthy humans [PDF]

, 2006
Exercise-induced abdominal muscle fatigue in healthy humans. J Appl Physiol 100: 1554–1562, 2006. First published January 19, 2006; doi:10.1152/japplphysiol.01389.2005.—The abdominal muscles have been shown to fatigue in response to voluntary ...
How, SC, Romer, LM, Taylor, BJ
core   +2 more sources

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source

Evaluation of Forearm Muscle Fatigue from Operating a Motorcycle Clutch [PDF]

, 2014
A laboratory experiment evaluated the effect of motorcycle clutch design on the electromyography (EMG) activity of the primary agonist finger flexor muscle in the forearm.
Conrad, Megan O., Marklin, Richard W.
core   +1 more source