Results 61 to 70 of about 2,506,948 (303)
Scientific ReportsThe ability for skeletal muscle to constantly generate force is limited by the muscle fatigue. The calcium ion plays a significant role of the cross-bridge cycle under fatigue conditions in the force generation of skeletal muscle.
Monan Wang +4 more
doaj +1 more source
Journal of Physical Therapy Science, 2016 [Purpose] The effect of duration of smartphone use on neck and shoulder muscle fatigue and pain was investigated in adults with forward head posture.
Seong-Yeol Kim, S. Koo
semanticscholar +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Neural Contributions to Muscle Fatigue: From the Brain to the Muscle and Back Again
Medicine & Science in Sports & Exercise, 2016 During exercise, there is a progressive reduction in the ability to produce muscle forces. Processes within the nervous system, as well as within the muscles contribute to this fatigue.
Janet L. Taylor +4 more
semanticscholar +1 more source
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
IEEE Transactions on Neural Systems and Rehabilitation EngineeringMuscle fatigue significantly impacts coordination, stability, and speed in daily activities. Accurate assessment of muscle fatigue is vital for effective exercise programs, injury prevention, and sports performance enhancement.
Jinxu Yu +6 more
doaj +1 more source
Postgraduate Medical Journal, 1975 Summary Muscle fatigue is a common symptom but there are no universally accepted methods for quantitating the function of voluntary muscle. This paper describes three main methods of assessment: simple clinical tests of muscle function; thermal probe measurements of metabolic heat production during muscular contraction; needle biopsy ...
openaire +1 more source
Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova +9 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem +9 more
wiley +1 more source
PLoS ONE, 2016 Background Rapid muscle fatigue during functional electrical stimulation (FES)-evoked muscle contractions in individuals with spinal cord injury (SCI) is a significant limitation to attaining health benefits of FES-exercise.
M. O. Ibitoye +4 more
semanticscholar +1 more source