Results 51 to 60 of about 407,530 (312)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Frontiers in Neurology, 2020 Activation of skeletal muscle contractions require that action potentials can be excited and propagated along the muscle fibers. Recent studies have revealed that muscle fiber excitability is regulated during repeated firing of action potentials by ...
Pieter Arnold Leermakers +9 more
doaj +1 more source
Functional and Structural Adaptations of Skeletal Muscle to Microgravity [PDF]
, 2001 Our purpose is to summarize the major effects of space travel on skeletal muscle with particular emphasis on factors that alter function. The primary deleterious changes are muscle atrophy and the associated decline in peak force and power.
Fitts, Robert +2 more
core +1 more source
Three-Dimensional Myoarchitecture of the Lower Esophageal Sphincter and Esophageal Hiatus Using Optical Sectioning Microscopy. [PDF]
, 2017 Studies to date have failed to reveal the anatomical counterpart of the lower esophageal sphincter (LES). We assessed the LES and esophageal hiatus morphology using a block containing the human LES and crural diaphragm, serially sectioned at 50 μm ...
Cheng, Leo K +3 more
core +2 more sources
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Journal of Physical Fitness and Sports Medicine, 2015 Heat shock protein 25 (Hsp25) phosphorylation plays a protective role following mechanical stress in skeletal muscle fibers. We previously reported that phosphorylation at serine 15 of Hsp25 (p-Ser15) was enhanced during regrowth of muscle fibers in rats
Fuminori Kawano +4 more
doaj +1 more source
Connectivity of the Superficial Muscles of the Human Perineum: A Diffusion Tensor Imaging-Based Global Tractography Study. [PDF]
, 2018 Despite the importance of pelvic floor muscles, significant controversy still exists about the true structural details of these muscles. We provide an objective analysis of the architecture and orientation of the superficial muscles of the perineum using
Cory, Esther +6 more
core +3 more sources
FEBS Open Bio, EarlyView.14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa +2 more
wiley +1 more source
Scientific Reports, 2022 Synchrotron X-ray computed tomography (SXCT) allows 3D imaging of tissue with a very large field of view and an excellent micron resolution and enables the investigation of muscle fiber atrophy in 3D.
Jessica Pingel +4 more
doaj +1 more source
Muscle fiber typology substantially influences time to recover from high-intensity exercise [PDF]
, 2020 Human fast-twitch muscle fi- bers generate high power in a short amount of time but are easily fatigued, whereas slow-twitch fibers are more fatigue resistant.
Bex, Tine +3 more
core +2 more sources