Results 241 to 250 of about 1,130,859 (302)

A Photothermally Amplified Enzyme–Nitric Oxide Co‐Regulatory System Reprograms Pathological ECM–Fibroblast Crosstalk to Alleviate Hypertrophic Scarring

Advanced Science, EarlyView.
An enzyme–nitric oxide (NO) co‐regulatory strategy reprograms pathological extracellular matrix (ECM)–fibroblast crosstalk in hypertrophic scars. Enzymatic degradation of pre‐existing ECM relieves aberrant mechanical cues, while NO‐mediated fibroblast phenotypic modulation restrains excessive collagen synthesis.
Junzhe Fu, Fan Jia, Yixian Mu, Wanzhe Liu, Dingqi Tang, Qiao Jin, Jian Ji, Youxiang Wang   +7 more
wiley   +1 more source

Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis

Advanced Science, EarlyView.
Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Shuo Zhang, Siteng Li, Wenzhong Chen, Qingcheng Song, Haiyue Zhao, Peng Wang, Yiran Zhang, Wenquan Liang, Shaowei Zheng, Juan Wang, Wei Chen, Yanbin Zhu, Yingze Zhang   +12 more
wiley   +1 more source

Genetic and Pharmacologic Inhibition of Myostatin Restores Muscle Mass in a Dynamin 2-Related Centronuclear Myopathy Mouse Model. [PDF]

J Cachexia Sarcopenia Muscle
Anne-Cécile D, David A, Mathias V, Valentine A, Chloé P, Quentin D, Esra K, Sidney C, Emmanuelle G, Louise C, Alexandre G, Josiane C, Aja P, Maximilien B, Baptiste M, Christophe H, Schaeffer L, Olli R, Marc B, Rémi M, Damien F.   +20 more
europepmc   +1 more source

Oxidative eustress is associated with AMPK and AKT activation, GLUT4 translocation and glucose uptake in skeletal muscle cells and fibres. [PDF]

Redox Rep
Martín-Prieto E, Catalano-Iniesta LA, Fernández-Puente E, Palomero J.   +3 more
europepmc   +1 more source

Predicting axial muscle-fibre strains in larval zebrafish. [PDF]

J Exp Biol
van Leeuwen JL, van Meer NMME, Lankheet MJ.   +2 more
europepmc   +1 more source

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Muscle fibre number is a possible determinant of muscle fibre composition in rats

Acta Physiologica Scandinavica, 1999
The purpose of the present study was to investigate whether the muscle fibre composition is related to the number of muscle fibres. To resolve this issue, we developed fast‐twitch fibre dominant rats (FFDR) by selective breeding and compared the findings to those of control rats (CR) obtained by random breeding.
M, Suwa, T, Nakamura, S, Katsuta
openaire   +2 more sources

Observations on “Detubulated” Muscle Fibres

Nature New Biology, 1972
GLYCEROL treatment of striated muscle1–3 has been widely assumed to be a means of disconnecting the transverse tubular system from the surface membrane. Exposure of a sartorius muscle to Ringer plus 400 mM glycerol followed by a return to Ringer, reduces the membrane capacity of superficial fibres and the muscle is mechanically inactive even though the
J, Zachar, D, Zacharova, R H, Adrian
openaire   +2 more sources