Results 231 to 240 of about 132,920 (293)

Cell Apoptosis and Glucocorticoid‐Induced Osteonecrosis

open access: yesMed Research, EarlyView.
The review identifies glucocorticoid‐induced osteocyte/osteoblast apoptosis as central to femoral head osteonecrosis (GION), mediated through STAT1‐caspase‐3, PI3K/Akt, Wnt/β‐catenin, and oxidative stress pathways. Emerging therapies targeting these pathways (e.g., HIF‐1α stabilization, AMPK activation, and exosome‐mediated miRNA delivery) show ...
Xiumei Tang   +7 more
wiley   +1 more source

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

open access: yesMed Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin   +8 more
wiley   +1 more source

Variants in CLCN1 and PDE4C Associated with Muscle Hypertrophy, Dysphagia, and Gait Abnormalities in Young French Bulldogs. [PDF]

open access: yesAnimals (Basel)
Shelton GD   +7 more
europepmc   +1 more source

Time‐resolved mapping of myocardial stiffness using 2D multifrequency spiral MR elastography with and without external vibration

open access: yesMagnetic Resonance in Medicine, EarlyView.
Abstract Purpose There is a clinical need for stiffness mapping of the heart; however, current cardiac magnetic resonance elastography (cMRE) has limited spatiotemporal resolution. Therefore, we developed 2D spiral multifrequency MRE of the human heart and conducted a study to analyze the consistency and reproducibility of motion‐encoding and stiffness
Matthias S. Anders   +14 more
wiley   +1 more source

Detrusor Overactivity and Urodynamics

open access: yesNeurourology and Urodynamics, EarlyView.
ABSTRACT While overactive bladder (OAB) is a clinical diagnosis, detrusor overactivity is identified through urodynamic testing. UDS is usually considered when primary treatment for OAB fails, because UDS is expensive, time consuming, invasive, and sometimes inaccurate, and it is not considered to influence treatment strategy substantially.
Laura N. Nguyen, Geneviève Nadeau
wiley   +1 more source

Acute Chemodenervation of the Bladder With Botulinum Toxin After Spinal Cord Injury Resulted in Preserved Bladder Function in Rodents

open access: yesNeurourology and Urodynamics, EarlyView.
ABSTRACT Despite modern bladder management methods, lower and upper urinary tract complications still contribute significantly to morbidity and diminished quality of life in persons with spinal cord injuries (SCI). Neurogenic overactive bladders often develop after SCI and this can result in loss of compliance, with concomitant urinary tract ...
Noor Al‐Khayat   +5 more
wiley   +1 more source

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