Results 271 to 280 of about 250,975 (359)

Lung‐Derived Small Extracellular Vesicles Containing miR‐15a‐5p/miR‐96‐5p Promote Myocardial Fibrosis in Hypertrophic Cardiomyopathy via Targeting SMAD7

open access: yesSmall, EarlyView.
Small extracellular vesicles (sEVs) are critical regulators of inter‐tissue communication in cardiovascular diseases. In this study, it is found that lung‐derived sEVs enhance cardiac fibroblasts activation and aggravates myocardial fibrosis progression in hypertrophic cardiomyopathy (HCM). sEVmiR‐15a‐5p and sEVmiR‐96‐5p exert this effect via targeting
Minwen Long   +10 more
wiley   +1 more source

Skeletal muscle hypertrophy rewires glucose metabolism: An experimental investigation and systematic review. [PDF]

open access: yesJ Cachexia Sarcopenia Muscle
Baumert P   +16 more
europepmc   +1 more source

Substrate Stiffness Modulates Fibroblast Extracellular Vesicle Secretion Via Mechanotransduction Pathways

open access: yesSmall, EarlyView.
Substrate stiffness shows modulation of the size and proteomic composition of mammary and cardiac fibroblast‐derived extracellular vesicles (EVs). Proteomics analyses and key protein inhibition studies reveal mechanotransduction pathways that regulate this stiffness‐tuned EV biogenesis in fibroblasts, offer new insight into how mechanical cues shape ...
Jun Yang   +4 more
wiley   +1 more source

Integrated Use of Oxidative Stress and Histological Biomarkers of T. tinca as Indicators of 17‐Alpha‐Ethynylestradiol Exposure

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT The potential adverse effects of 17‐alpha‐ethynylestradiol (50, 100, and 500 μg EE2/kg b.w., for 30 days) on tench (Tinca tinca) were evaluated by integrating biomarkers including physiological (hepato‐somatic index, spleen‐somatic index, and hematocrit), oxidative stress (catalase, glutathione peroxidase, and glutathione reductase activities;
Ana L. Oropesa   +3 more
wiley   +1 more source

Integrated multi‐omics analysis reveals metabolic reprogramming as a key driver of angiotensin II‐induced vascular remodeling

open access: yesVIEW, EarlyView.
This study investigates the molecular alterations underlying angiotensin II (Ang II)‐induced vascular remodeling in cardiovascular diseases using a multi‐omics approach. Through data exploration and integrated multi‐omics analysis, our findings reveal that Ang II‐driven vascular injury in vascular smooth muscle cells is mediated by metabolic ...
Yiwei Hu   +8 more
wiley   +1 more source

Intracavernous Drug Delivery System [PDF]

open access: yes, 1990
Kulvelis, F.   +5 more
core  

Abdominal squamous cell carcinoma in an adult domestic pig (Sus scrofa domesticus) with multiorgan metastases

open access: yesVeterinary Record Case Reports, EarlyView.
Abstract A variety of neoplasms are reported in pigs and should be considered as a cause of ill health in individuals. Squamous cell carcinomas are a common neoplasm of many domestic species, but are rarely reported in pigs. This report describes a case of a very large abdominal squamous cell carcinoma, detected on postmortem examination of a mature ...
Henry George Miller   +3 more
wiley   +1 more source

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