Results 41 to 50 of about 779,091 (316)

Increasing muscle mass to improve metabolism [PDF]

Adipocyte, 2013
Skeletal muscle insulin resistance is a predictor of the development of type 2 diabetes and maintenance of adequate muscle glucose disposal in muscle may help to prevent diabetes. Lipodystrophy is a type of diabetes caused by a reduction of white adipose tissue and the adipokine leptin.
McPherron, Alexandra C., Guo, Tingqing, Bond, Nichole D., Gavrilova, Oksana   +3 more
openaire   +2 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Transcriptomic analysis demonstrates moderators of muscle quality are altered in age-related sarcopenic obesity

BMC Genomics
Background Sarcopenic obesity (SO) is the combined condition of sarcopenia and obesity, which commonly occurs in the older adult population. SO is associated with poor physical function, increased risk of musculoskeletal injury, and reduced quality of ...
Eleanor R. Schrems, Ana Regina Cabrera, Ronald G. Jones, Francielly Morena, Kevin A. Murach, Nicholas P. Greene, Tyrone A. Washington   +6 more
doaj   +1 more source

Body Composition Characteristics of Community-Dwelling Older Adults With Dynapenia

Frontiers in Nutrition, 2022
This study aimed to determine the differences in muscle and fat masses of the arm and leg between older adults with dynapenia, sarcopenia, or presarcopenia and normal individuals.
Hungu Jung, Hungu Jung, Shigeharu Tanaka, Shigeharu Tanaka, Ryo Tanaka   +4 more
doaj   +1 more source

Bioelectrical Impedance Analysis and Mid-Upper Arm Muscle Circumference Can Be Used to Detect Low Muscle Mass in Clinical Practice [PDF]

, 2021
Dorienke Gort‐van Dijk, Linda B.M. Weerink, Miloš Milovanović, Jan-Willem Haveman, Patrick Hemmer, Gerard Dijkstra, Robert Lindeboom, Marjo Campmans‐Kuijpers   +7 more
openalex   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Impact of probiotics on muscle mass, muscle strength and lean mass: a systematic review and meta‐analysis of randomized controlled trials

Journal of Cachexia, Sarcopenia and Muscle, 2023
Probiotics have shown potential to counteract sarcopenia, although the extent to which they can influence domains of sarcopenia such as muscle mass and strength in humans is unclear.
Konstantinos Prokopidis, Panagiotis Giannos, Richard Kirwan, Theocharis Ispoglou, Francesco Galli, Oliver C. Witard, Konstantinos K. Triantafyllidis, Konstantinos S. Kechagias, Jordi Morwani‐Mangnani, Andrea Ticinesi, Masoud Isanejad   +10 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Mitochondrial Quality Control and Muscle Mass Maintenance [PDF]

Frontiers in Physiology, 2016
Loss of muscle mass and force occurs in many diseases such as disuse/inactivity, diabetes, cancer, renal, and cardiac failure and in aging-sarcopenia. In these catabolic conditions the mitochondrial content, morphology and function are greatly affected.
Vanina eRomanello, Marco eSandri, Marco eSandri, Marco eSandri, Marco eSandri   +4 more
openaire   +4 more sources