Results 91 to 100 of about 7,792,195 (427)

Identification of an FHL1 protein complex containing gamma-actin and non-muscle myosin IIB by analysis of protein-protein interactions. [PDF]

PLoS ONE, 2013
FHL1 is multifunctional and serves as a modular protein binding interface to mediate protein-protein interactions. In skeletal muscle, FHL1 is involved in sarcomere assembly, differentiation, growth, and biomechanical stress.
Lili Wang, Jianing Miao, Lianyong Li, Di Wu, Yi Zhang, Zhaohong Peng, Lijun Zhang, Zhengwei Yuan, Kailai Sun   +8 more
doaj   +1 more source

Post-transcriptional regulation of satellite cell quiescence by TTP-mediated mRNA decay. [PDF]

, 2015
Skeletal muscle satellite cells in their niche are quiescent and upon muscle injury, exit quiescence, proliferate to repair muscle tissue, and self-renew to replenish the satellite cell population.
Blackshear, Perry J, Cadwallader, Adam B, Clement, Sandra L, Doles, Jason D, Hall, Monica N, Hausburg, Melissa A, Lykke-Andersen, Jens, Olwin, Bradley B   +7 more
core   +2 more sources

HCT116 colorectal liver metastases exacerbate muscle wasting in a mouse model for the study of colorectal cancer cachexia [PDF]

, 2020
Colorectal cancer (CRC) is often accompanied by formation of liver metastases (LM) and skeletal muscle wasting, i.e. cachexia. Despite affecting the majority of CRC patients, cachexia remains underserved, understudied and uncured.
Bonetto, Andrea, Huot, Joshua R., Novinger, Leah J., Pin, Fabrizio   +3 more
core   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

The effect of strength training on muscle cellular stress in prostate cancer patients on ADT

Endocrine Connections, 2016
Background Androgen deprivation therapy (ADT) for prostate cancer (PCa) is associated with several side effects, including loss of muscle mass. Muscle atrophy is associated with reduced mitochondrial function and increased muscle cellular stress that may
T S Nilsen, L Thorsen, C Kirkegaard, I Ugelstad, S D Fosså, T Raastad   +5 more
doaj   +1 more source

FHL1 activates myostatin signalling in skeletal muscle and promotes atrophy [PDF]

, 2015
Myostatin is a TGFβ family ligand that reduces muscle mass. In cancer cells, TGFβ signalling is increased by the protein FHL1. Consequently, FHL1 may promote signalling by myostatin. We therefore tested the ability of FHL1 to regulate myostatin function.
Bloch, Brown, Carlson, Cowling, Cruz-Jentoft, Dedieu, Degens, Dennler, Ding, Durieux, Ellis, Favot, Gollins, Gregorevic, Grobet, Hennebry, Jespersen, Larsson, Lee, McFarlane, McMahon, McPherron, Mosher, Natanek, Niwa, Okabe, Plant, Raffaello, Reisz-Porszasz, Riddoch Contreras, Roth, Sirca, Sullivan, Swallow, Windpassinger, Zhang   +35 more
core   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Age-related deficits in skeletal muscle recovery following disuse are associated with neuromuscular junction instability and ER stress, not impaired protein synthesis. [PDF]

, 2016
Age-related loss of muscle mass and strength can be accelerated by impaired recovery of muscle mass following a transient atrophic stimulus. The aim of this study was to identify the mechanisms underlying the attenuated recovery of muscle mass and ...
Baar, Keith, Baehr, Leslie M, Bodine, Sue C, De Sousa, Luis Gustavo, Marcotte, George, Marshall, Andrea G, West, Daniel WD   +6 more
core   +2 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

The secretome of skeletal muscle cells: A systematic review

Osteoarthritis and Cartilage Open, 2020
Background: Proteomic studies of the secretome of skeletal muscle cells can help us understand the processes that govern the synthesis, systemic interactions and organization of skeletal muscle and identify proteins that are involved in muscular ...
Antoine Florin, Cécile Lambert, Christelle Sanchez, Jérémie Zappia, Nancy Durieux, Antonio Martins Tieppo, Ali Mobasheri, Yves Henrotin   +7 more
doaj