Results 191 to 200 of about 663,430 (263)

ELABELA Targets Mitochondria to Modulate Heart Development

Advanced Science, EarlyView.
The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang, Qingjie Wang, Zhikang Xu, Shuang Zhou, Yue Zhou, Junjie Yang, Lingfeng Tong, Zhuo Meng, Mei Yang, Wen Zhao, Tie Yang, Hualin Wang, Jun Zhang, Rubin Tan, Lei Wang, Yuqiang Huang, Bin Zhou, Sun Chen, Bing Zhang, Jinxiang Yuan, Jianyuan Zhao, Alex F. Chen, Kun Sun   +22 more
wiley   +1 more source

Exercise and Skeletal Muscle-Derived Extracellular Vesicles: Their Cargo, Release, and Role in Metabolic Regulation. [PDF]

J Extracell Biol
Boulestreau J, Ferguson SK, Nelson L, Polgar N.   +3 more
europepmc   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

The pleiotropic impact of chaperone-mediated autophagy on skeletal muscle integrity. [PDF]

Autophagy
Dialynaki D, Klionsky DJ.
europepmc   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Impact of Freezing on the Nanoarchitecture and Techno-Functional Properties of Camel Myofibrillar Proteins: Insights From Atomic Force Microscopy. [PDF]

Food Sci Nutr
Hamza AL, Abderrahmen R, Nora C, Sandra B, Nacira R, Sajid M, Jafari SM.   +6 more
europepmc   +1 more source

Characterization of Fiber-Type Composition and Phosphoproteins of Fast- and Slow-Growing Broilers. [PDF]

Animals (Basel)
Li Y, Huo W, Weng K, Liu J, Gu Y, Cai Y, Zhang Y, Zhang Y, Hu X, Chen G, Xu Q.   +10 more
europepmc   +1 more source

Unfolding Resilience: Molecular Integration of the Integrated Stress Response and Mitochondrial UPR in Skeletal Muscle Homeostasis. [PDF]

Muscles
Sanfrancesco VC, Della Mea D, Hood DA.
europepmc   +1 more source

From homeostasis to pathology, organelle-specific autophagy in skeletal muscle: a PRISMA-ScR scoping review. [PDF]

Front Physiol
Wang C, Liu G, Guo C, Li Q, Wang F, Zhang M.   +5 more
europepmc   +1 more source

Formation of Liver Metastases Is Accompanied by Accelerated Musculoskeletal Deficits in LLC Tumor Hosts. [PDF]

Int J Mol Sci
Gonzalez PO, Miller AM, Polo LFC, Plotkin LI, Pin F, Huot JR.   +5 more
europepmc   +1 more source