Results 281 to 290 of about 44,957 (351)

SOX6 enhances vascular smooth muscle cell phenotypic switching and elevates blood pressure by activating autophagy

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Sox6 expression is elevated in hypertensive conditions and promotes vascular smooth muscle cell phenotypic switching through autophagy activation. Using gain‐ and loss‐of‐function approaches both in vitro and in vivo, we demonstrate that Sox6 regulates blood pressure and vascular remodeling, highlighting its potential as a novel therapeutic target for ...
Qianhui Ling   +7 more
wiley   +1 more source

TRACHEAL SMOOTH MUSCLE RELAXANT EFFECT OF KETAMINE

open access: bronze, 1974
Paul M. Lundy   +2 more
openalex   +1 more source

Research advances in dysphagia animal models

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This review systematically summarizes the establishment, evaluation, and detection of dysphagia animal models in stroke, Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) in three kinds of experimental animals (including rodents, nonhuman primates, and other mammals), providing a basis for the selection of appropriate animal models of ...
Junhui Bai   +5 more
wiley   +1 more source

Cyclo‐Octasulfur Crystals as Light‐Controlled Molecular Muscles

open access: yesAngewandte Chemie, EarlyView.
Bending and stretching effect provoked by the repeated application of 385‐nm radiation (purple) and 475‐nm radiation (blue) on sulfur microcrystals. Abstract Here, we describe the synthesis and photo‐responsive properties of 2D cyclo‐octasulfur microcrystals (α‐S8 MCs), produced using a quick, simple, cost‐effective, and environmentally friendly ...
Enrique Solano‐Rodríguez   +5 more
wiley   +2 more sources

Development of an efficient mice model of cancer‐associated cardiac cachexia

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This work establishes a preclinical framework for targeting ubiquitin pathways to mitigate the morbidity of cancer‐related cardiopathy. Our integrated approach delineates a hierarchical progression from subcellular dysfunction to macroscopic cardiac deterioration. These findings mechanistically link tumor‐induced cachexia to cardiac dysfunction through
Shijie Xiong   +9 more
wiley   +1 more source

Bioprinting‐Assisted Tissue Assembly to Investigate Endothelial Cell Contributions in Cardiac Fibrosis and Focal Fibrosis Modeling

open access: yesAdvanced NanoBiomed Research, EarlyView.
GA: Bioprinting‐assisted tissue assembly, a method for generating versatile and complex tissue constructs, is employed to investigate the contribution of endothelial cells (ECs) in cardiac fibrosis. ECs modulate fibrotic responses not only by preventing significant tissue stiffening and contractile impairment but also by exhibiting endothelial‐to ...
Dong Gyu Hwang   +6 more
wiley   +1 more source

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