Results 221 to 230 of about 105,201 (288)
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[Combination of central and peripheral muscle relaxants in the treatment of post-stroke spasticity].
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2019AIM To study the electromiographic (EMG) parameters and to evaluate the therapeutic efficacy of a combination of central (baclofen, baclosan) and peripheral (incobotulotoxinA, xeomin) muscle relaxants in the treatment of post-stroke spasticity (PSS ...
D. Iskra +3 more
semanticscholar +3 more sources
A peripheral component of centrally acting muscle relaxants: chlormezanone and mephenesin.
The Journal of Pharmacology and Experimental Therapeutics, 1967Blockade of the polysynaptic reflex arc has been used as an assay for the actions of " central muscle relaxants" and other noncurariform relaxants. A modification of Eccles stimulus interval contraction curve has been utilized to elucidate the peripheral
F. Rosenberg, W. Cooke
semanticscholar +3 more sources
Spine, 2023
Study Design. Retrospective, single-center, cohort study. Objective. Investigate whether the incidence of postoperative delirium in older adults undergoing spinal fusion surgery is associated with postoperative muscle relaxant administration.
E. Perez +10 more
semanticscholar +1 more source
Study Design. Retrospective, single-center, cohort study. Objective. Investigate whether the incidence of postoperative delirium in older adults undergoing spinal fusion surgery is associated with postoperative muscle relaxant administration.
E. Perez +10 more
semanticscholar +1 more source
Clinical pharmacology and therapy, 2020
The recent opioid prescribing guideline cautions about the concomitant prescribing of opioids and skeletal muscle relaxants (SMRs) given the additive central nervous system depressant effect. However, the clinical relevance remains unclear.
Yan Li +6 more
semanticscholar +1 more source
The recent opioid prescribing guideline cautions about the concomitant prescribing of opioids and skeletal muscle relaxants (SMRs) given the additive central nervous system depressant effect. However, the clinical relevance remains unclear.
Yan Li +6 more
semanticscholar +1 more source
Muscle Relaxant Action of MS-322, a New Centrally Acting Muscle Relaxant, in Rats
General Pharmacology: The Vascular System, 19981. The pharmacological properties of (R)-(+)-3-phenyl-5-¿2-(1-pyrrolidinylmethyl)-butyryl¿isoxazole hydrochloride (MS-322) were investigated and compared with those of other muscle relaxants. 2. MS-322 (3-12 mg/kg, IV) reduced spinal reflex potentials in acutely spinalized rats dose dependently.
T, Otsu, T, Nagao, H, Ono
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Cyclobenzaprine: A novel centrally acting skeletal muscle relaxant
Neuropharmacology, 1975Abstract The muscle relaxant activity of cyclobenzaprine relative to chlorpromazine and diazepam in several animal models manifesting hypertonic skeletal muscle activity is described. In mice subjected to electrical and chemical induced tonic-extensor seizures, only cyclobenzaprine achieved a protective index greater than unity in all preparations ...
N N, Share, C S, McFarlane
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Centrally acting oral skeletal muscle relaxants
American Journal of Health-System Pharmacy, 1980A critical examination of the literature on centrally acting, orally administered skeletal muscle relaxants (SMRs) is presented. The available comparative clinical studies are reviewed, and the pharmacology, metabolism and adverse effects of the oral SMRs are discussed briefly. The drugs covered are carisoprodol, chlorphenesin carbamate, chlorzoxazone,
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Pharmacological properties of NK433, a new centrally acting muscle relaxant
European Journal of Pharmacology, 1995The pharmacological properties of NK433 ((-)-(R)-2-methyl-3-(1-pyrrolidinyl)-4'-trifluoromethylpropiophenone+ ++ monohydrochloride), a novel muscle relaxant, were investigated. NK433 inhibited intercollicular decerebrate rigidity (gamma-rigidity) and anemic decerebrate rigidity (alpha-rigidity) dose dependently.
K, Sakitama +4 more
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Differential sensitivity of the flexor reflex to centrally acting muscle relaxants
Toxicology and Applied Pharmacology, 1960Abstract Mephenesin, methocarbamol, styramate, and chlorzoxazone are alike in their ability to depress the flexor reflex of the intact chloralose-urethane-anesthetized cat at doses that leave the patellar reflex unchanged.
L B, WITKIN, P, SPITALETTA
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