Results 251 to 260 of about 17,821 (298)
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Cyclobenzaprine: A novel centrally acting skeletal muscle relaxant
Neuropharmacology, 1975Abstract The muscle relaxant activity of cyclobenzaprine relative to chlorpromazine and diazepam in several animal models manifesting hypertonic skeletal muscle activity is described. In mice subjected to electrical and chemical induced tonic-extensor seizures, only cyclobenzaprine achieved a protective index greater than unity in all preparations ...
N.N. Share, C.S. McFarlane
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Central Nervous System Effects of Intrathecal Muscle Relaxants in Rats
Anesthesia & Analgesia, 1993When given for a sufficient time and dose intravenously, neuromuscular blocking drugs eventually can enter the cerebrospinal fluid (CSF). To study the potential pharmacologic consequences of neuromuscular blocking drugs in the CSF, a model was developed in the rat by using an intrathecal infusion of these drugs.
Anthony J. Trevor +6 more
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Pharmacological properties of NK433, a new centrally acting muscle relaxant
European Journal of Pharmacology, 1995The pharmacological properties of NK433 ((-)-(R)-2-methyl-3-(1-pyrrolidinyl)-4'-trifluoromethylpropiophenone+ ++ monohydrochloride), a novel muscle relaxant, were investigated. NK433 inhibited intercollicular decerebrate rigidity (gamma-rigidity) and anemic decerebrate rigidity (alpha-rigidity) dose dependently.
Michio Ishikawa +4 more
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Centrally acting oral skeletal muscle relaxants
American Journal of Health-System Pharmacy, 1980A critical examination of the literature on centrally acting, orally administered skeletal muscle relaxants (SMRs) is presented. The available comparative clinical studies are reviewed, and the pharmacology, metabolism and adverse effects of the oral SMRs are discussed briefly. The drugs covered are carisoprodol, chlorphenesin carbamate, chlorzoxazone,
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Effects of tizanidine, a centrally acting muscle relaxant, on motor systems
General Pharmacology: The Vascular System, 1986Effects of tizanidine were studied with special reference to the effect on motor systems. The drug effectively reduced the intercollicular decerebrate rigidity and gamma-activity indirectly recorded from muscle spindle afferent discharges without showing the direct inhibitory effect on muscle spindles in rats.
Koki Kato +8 more
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Differential sensitivity of the flexor reflex to centrally acting muscle relaxants
Toxicology and Applied Pharmacology, 1960Abstract Mephenesin, methocarbamol, styramate, and chlorzoxazone are alike in their ability to depress the flexor reflex of the intact chloralose-urethane-anesthetized cat at doses that leave the patellar reflex unchanged.
Patrick Spitaletta, Lloyd B. Witkin
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Glyceryl Guaiacolate: a Centrally Acting Muscle Relaxant
Equine Veterinary Journal, 1970SummaryA review of the history of centrally‐acting muscle relaxants has been given. The centrally‐acting muscle relaxant glyceryl guaiacolate has been used extensively in continental Europe and, within recent years, has attracted the attention of North American workers. The pharmacological properties of the drug have been described.
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Biofeedback and Self-Regulation, 1980
The relationship of "awareness of muscle tension" to depth of relaxation was explored. In one experiment, accuracy of forearm flexor control was assessed using the psychophysical method of magnitude production, and depth of flexor relaxation was measured using the integrated EMG before and after EMG biofeedback training.
Irwin Matus +2 more
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The relationship of "awareness of muscle tension" to depth of relaxation was explored. In one experiment, accuracy of forearm flexor control was assessed using the psychophysical method of magnitude production, and depth of flexor relaxation was measured using the integrated EMG before and after EMG biofeedback training.
Irwin Matus +2 more
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Effects of NK433, a new centrally acting muscle relaxant, on masticatory muscle reflexes in rats
European Journal of Pharmacology, 1996The effects of (-)-(R)-2-methyl-3-(1-pyrrolidinyl)-4'- trifluoromethylpropiophenone monohydrochloride (NK433), a novel centrally acting muscle relaxant, on masticatory muscle reflexes were investigated in rats. NK433 inhibited the monosynaptic tonic vibration reflex of the masseter muscle and the polysynaptic tonic periodontal masseteric reflex.
Michio Ishikawa +3 more
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Neuropharmacology, 2006
Thiocolchicoside (TCC) is used clinically for its muscle relaxant, anti-inflammatory, and analgesic properties, and it has been shown to interact with gamma-aminobutyric acid (GABA) type A receptors (GABAARs) and strychnine-sensitive glycine receptors in the rat central nervous system.
Carta Mario +7 more
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Thiocolchicoside (TCC) is used clinically for its muscle relaxant, anti-inflammatory, and analgesic properties, and it has been shown to interact with gamma-aminobutyric acid (GABA) type A receptors (GABAARs) and strychnine-sensitive glycine receptors in the rat central nervous system.
Carta Mario +7 more
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