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Effects of Tizanidine hydrochloride, a centrally acting muscle relaxant, on central nervous system
Effects of Tizanidine hydrochloride, a centrally acting muscle relaxant, on central nervous systemopenaire
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Cyclobenzaprine: A novel centrally acting skeletal muscle relaxant
Neuropharmacology, 1975Abstract The muscle relaxant activity of cyclobenzaprine relative to chlorpromazine and diazepam in several animal models manifesting hypertonic skeletal muscle activity is described. In mice subjected to electrical and chemical induced tonic-extensor seizures, only cyclobenzaprine achieved a protective index greater than unity in all preparations ...
N N, Share, C S, McFarlane
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Muscle Relaxant Action of MS-322, a New Centrally Acting Muscle Relaxant, in Rats
General Pharmacology: The Vascular System, 19981. The pharmacological properties of (R)-(+)-3-phenyl-5-¿2-(1-pyrrolidinylmethyl)-butyryl¿isoxazole hydrochloride (MS-322) were investigated and compared with those of other muscle relaxants. 2. MS-322 (3-12 mg/kg, IV) reduced spinal reflex potentials in acutely spinalized rats dose dependently.
T, Otsu, T, Nagao, H, Ono
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Centrally acting oral skeletal muscle relaxants
American Journal of Health-System Pharmacy, 1980A critical examination of the literature on centrally acting, orally administered skeletal muscle relaxants (SMRs) is presented. The available comparative clinical studies are reviewed, and the pharmacology, metabolism and adverse effects of the oral SMRs are discussed briefly. The drugs covered are carisoprodol, chlorphenesin carbamate, chlorzoxazone,
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Pharmacological properties of NK433, a new centrally acting muscle relaxant
European Journal of Pharmacology, 1995The pharmacological properties of NK433 ((-)-(R)-2-methyl-3-(1-pyrrolidinyl)-4'-trifluoromethylpropiophenone+ ++ monohydrochloride), a novel muscle relaxant, were investigated. NK433 inhibited intercollicular decerebrate rigidity (gamma-rigidity) and anemic decerebrate rigidity (alpha-rigidity) dose dependently.
K, Sakitama +4 more
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Central Nervous System Effects of Intrathecal Muscle Relaxants in Rats
Anesthesia & Analgesia, 1993When given for a sufficient time and dose intravenously, neuromuscular blocking drugs eventually can enter the cerebrospinal fluid (CSF). To study the potential pharmacologic consequences of neuromuscular blocking drugs in the CSF, a model was developed in the rat by using an intrathecal infusion of these drugs.
J, Szenohradszky +6 more
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Glyceryl Guaiacolate: a Centrally Acting Muscle Relaxant
Equine Veterinary Journal, 1970Summary A review of the history of centrally‐acting muscle relaxants has been given. The centrally‐acting muscle relaxant glyceryl guaiacolate has been used extensively in continental Europe and, within recent years, has attracted the attention of North American workers.
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Three novel benzothiazine-fused triazoles as potential centrally acting muscle relaxants
Acta Crystallographica Section C Crystal Structure Communications, 2012The structures of the novel triazolobenzothiazines 2,4-dihydro-1H-benzo[b][1,2,4]triazolo[4,3-d][1,4]thiazin-1-one (IDPH-791), C9H7N3OS, (I), a potential muscle relaxant, its benzoyl derivative, 2-(2-oxo-2-phenylethyl)-2,4-dihydro-1H-benzo[b][1,2,4]triazolo[4,3-d][1,4]thiazin-1-one, C20H17N3O4S, (II), and the β-keto ester derivative, ethyl 3-oxo-2-(1 ...
Krishnan, Ravikumar +3 more
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Cyclobenzaprine, a centrally acting muscle relaxant, acts on descending serotonergic systems
European Journal of Pharmacology, 1996The centrally acting muscle relaxant cyclobenzaprine was thought to be an alpha 2-adrenoceptor agonist that reduced muscle tone by decreasing the activity of descending noradrenergic neurons. In the present study, we examined the effects of cyclobenzaprine on descending neurons by measuring the monosynaptic reflex in rats.
H, Kobayashi, Y, Hasegawa, H, Ono
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