Results 31 to 40 of about 18,960 (304)

Pediatric fibromyalgia

Reumatismo, 2012
Fibromyalgia (FM) is currently defined as chronic widespread pain (CWP) with allodynia or hyperalgesia to pressure pain. It is classified as one of the large group of soft-tissue pain syndromes.
J. Ablin, D. Buskila
doaj   +1 more source

Review of Anesthesia for Middle Ear Surgery [PDF]

, 2010
Special considerations for middle ear surgery include a bloodless surgical field, attention to patient head positioning, facial nerve monitoring, and management of postoperative nausea and vomiting.
Irwin, MG, Liang, S
core   +1 more source

Skeletal muscle relaxants as adjunctive pain control following cardiothoracic surgery: a systematic review protocol

BMJ Open
Introduction Multimodal pain control following cardiothoracic surgery remains a focus in international guidelines. We hypothesise that non-depolarising skeletal muscle relaxants can prove to be a useful adjunct for this population.Methods/analysis This ...
Travis W Murphy, Shadman Kabir, Quinn Whaley, Melissa Fernandez   +3 more
doaj   +1 more source

A health-system-embedded deprescribing intervention targeting patients and providers to prevent falls in older adults (STOP-FALLS trial): study protocol for a pragmatic cluster-randomized controlled trial

Trials, 2023
Background Central nervous system (CNS) active medications have been consistently linked to falls in older people. However, few randomized trials have evaluated whether CNS-active medication reduction reduces falls and fall-related injuries.
Benjamin H. Balderson, Shelly L. Gray, Monica M. Fujii, Kanichi G. Nakata, Brian D. Williamson, Andrea J. Cook, Robert Wellman, Mary Kay Theis, Cara C. Lewis, Dustin Key, Elizabeth A. Phelan   +10 more
doaj   +1 more source

Pediatric fulminant malignant hyperthermia with severe electroencephalographic abnormality and brain damage: a case report

Journal of Medical Case Reports, 2023
Background Malignant hyperthermia is an extremely dangerous condition that can occur with exposure to volatile inhalant anesthetics and depolarizing muscle relaxants, and that requires immediate intervention.
Sakura Minami, Azusa Ikeda, Kaori Yamada, Aya Kajihama, Hiroyuki Shimizu, Hiroyuki Nagafuchi   +5 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Efficacy and acceptability of pharmacological and non-pharmacological interventions for non-specific chronic low back pain: a protocol for a systematic review and network meta-analysis

Systematic Reviews, 2020
Background Despite the enormous financial and humanistic burden of chronic low back pain (CLBP), there is little consensus on what constitutes the best treatment options from a multitude of competing interventions.
Trevor Thompson, Sofia Dias, Damian Poulter, Sharon Weldon, Lucy Marsh, Claire Rossato, Jae Il Shin, Joseph Firth, Nicola Veronese, Elena Dragioti, Brendon Stubbs, Marco Solmi, Christopher G. Maher, Andrea Cipriani, John P. A. Ioannidis   +14 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Update on fibromyalgia

Italian Journal of Medicine, 2012
IntroductionFibromyalgia (FM) is a chronic pain syndrome characterized by widespread pain, fatigue, sleep alterations, and distress. It affects at least 2% of the adult population.
Fabiola Atzeni, Marco Cazzola, Piercarlo Sarzi-Puttini   +2 more
doaj   +1 more source

Molecular genetic analysis for malignant hyperthermia : a thesis presented to Massey University in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry [PDF]

, 2004
Malignant hyperthermia (MH) is a rare pharmacogenetic disorder in humans caused by inhalational general anaesthetics and depolarising muscle relaxants. An MH reaction shows abnormal calcium homeostasis in skeletal muscle leading to a hypermetabolic state
Sato, Keisaku
core