Results 111 to 120 of about 8,631,981 (422)
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
Increased skeletal muscle 11βHSD1 mRNA is associated with lower muscle strength in ageing. [PDF]
PLoS ONE, 2013 BACKGROUND:Sarcopenia, the loss of muscle mass and function with age, is associated with increased morbidity and mortality. Current understanding of the underlying mechanisms is limited.
Alixe H M Kilgour +13 more
doaj +1 more source
Automatic Mammogram image Breast Region Extraction and Removal of Pectoral Muscle [PDF]
International Journal of Scientific & Engineering Research, Volume
4, Issue 5, May-2013 1727, 2013 Currently Mammography is a most effective imaging modality used by radiologists for the screening of breast cancer. Finding an accurate, robust and efficient breast region segmentation technique still remains a challenging problem in digital mammography.
arxiv
MUSCLE: Strengthening Semi-Supervised Learning Via Concurrent Unsupervised Learning Using Mutual Information Maximization [PDF]
arXiv, 2020 Deep neural networks are powerful, massively parameterized machine learning models that have been shown to perform well in supervised learning tasks. However, very large amounts of labeled data are usually needed to train deep neural networks. Several semi-supervised learning approaches have been proposed to train neural networks using smaller amounts ...
arxiv
THE-FAME: THreshold based Energy-efficient FAtigue MEasurment for Wireless Body Area Sensor Networks using Multiple Sinks [PDF]
, 2013 Wireless Body Area Sensor Network (WBASN) is a technology employed mainly for patient health monitoring. New research is being done to take the technology to the next level i.e. player's fatigue monitoring in sports. Muscle fatigue is the main cause of player's performance degradation. This type of fatigue can be measured by sensing the accumulation of
arxiv +1 more source
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
Bipedal Robot Running: Human-like Actuation Timing Using Fast and Slow Adaptations [PDF]
arXiv, 2023 We have been developing human-sized biped robots based on passive dynamic mechanisms. In human locomotion, the muscles activate at the same rate relative to the gait cycle during running. To achieve adaptive running for robots, such characteristics should be reproduced to yield the desired effect, In this study, we designed a central pattern generator (
arxiv
Size of the Extracellular Compartment of Skeletal Muscle
Experimental Biology and Medicine, 1939 The water of the animal body may be roughly divided into that contained within the cells, the intercellular fluid, and that contained in the fluid which bathes the cells but is not enclosed by the cell membrane, the extracellular fluid. There have been numerous attempts in recent years to determine the relative size of each of these compartments.
A. M. Lands, P. S. Larson, R. A. Cutting
openaire +2 more sources
Interplay of integrins and selectins in metastasis
Molecular Oncology, EarlyView.Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva +2 more
wiley +1 more source
Frontiers in Computational Neuroscience, 2012 The fibers in a skeletal muscle are divided into groups called "muscle units" whereby each muscle unit is innervated by a single neuron. It was found that neurons with low activation thresholds have smaller muscle units than neurons with higher
Irit eNowik, Shmuel eZamir, Idan eSegev
doaj +1 more source