Results 81 to 90 of about 5,985,809 (299)

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Scallop swimming kinematics and muscle performance: modelling the effects of "within-animal" variation in temperature sensitivity [PDF]

, 2005
Escape behaviour was investigated in Queen scallops (Aequipecten opercularis) acclimated to 5, 10 or 15 degrees C and tested at their acclimation temperature.
Bailey, DM, Bailey, D.M., Johnstone, I.A., Johnston, Ian Alistair, Bailey, D, Johnston, Ian Alistair; id_orcid   +5 more
core   +1 more source

Nur77 deletion impairs muscle growth during developmental myogenesis and muscle regeneration in mice.

PLoS ONE, 2017
Muscle atrophy is a prevalent condition in illness and aging. Identifying novel pathways that control muscle mass may lead to therapeutic advancement. We previously identified Nur77 as a transcriptional regulator of glycolysis in skeletal muscle.
Omar Cortez-Toledo, Caitlin Schnair, Peer Sangngern, Daniel Metzger, Lily C Chao   +4 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

LIM and cysteine-rich domains 1 (LMCD1) regulates skeletal muscle hypertrophy, calcium handling, and force

, 2019
Background: Skeletal muscle mass and strength are crucial determinants of health. Muscle mass loss is associated with weakness, fatigue, and insulin resistance.
Cheng, Arthur J.,, Chaillou, Thomas,, Martínez-Redondo, Vicente,, Izadi, Manizheh,, Porsmyr-Palmertz, Margareta,, Ruas, Jorge L,, Lanner, Johanna T.,, Hansson, Alicia,, Cervenka, Igor,, Agudelo, Leandro Z.,, Nair, K. Sreekumaran,, Estall, Jennifer L.,, Ferreira, Duarte M. S.,, Robinson, Matthew M.,, Valente-Silva, Paula,, Correia, Jorge C.,, Pettersson-Klein, Amanda T.,   +16 more
core   +1 more source

Estimation of changes in volume of individual lower-limb muscles using magnetic resonance imaging (during bed-rest) [PDF]

, 2010
Muscle size in the lower limb is commonly assessed in neuromuscular research as it correlates with muscle function and some approaches have been assessed for their ability to provide valid estimates of muscle volume.
Miokovic, Tanja, Rittweger, Jörn, T Miokovic, Felsenberg, Dieter, J Rittweger, D L Belavý, Belavy, Daniel Ludovic, D Felsenberg   +7 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Muscle x-ray attenuation is not decreased during experimental bed rest. [PDF]

, 2013
Muscle X-ray attenuation (MXA) in Hounsfield units (HU) is decreased in dystrophy, aging, and immobilization. We hypothesized a decrease also during bed rest (BR).
Bareille, MARIE-PIERRE, Rittweger, Jörn, Felsenberg, Dieter, Müller, Klaus   +3 more
core   +1 more source

Longitudinal changes in hamstring muscle morphology in adolescent competitive alpine skiers are sex-specific: a 4-year cohort study

Annals of Medicine
Background The aim of this study was to investigate changes in hamstring architecture and size over a 4-year period, explore sex-specific differences, and examine associations with biological maturation in adolescent competitive alpine skiers.Materials ...
Daniel P. Fitze, Jonas Hanimann, Martino V. Franchi, Stefan Fröhlich, Johannes Scherr, Jess G. Snedeker, Reto Sutter, Jörg Spörri   +7 more
doaj   +1 more source