Results 111 to 120 of about 1,566,168 (324)

Altered Dopamine Metabolism and Response to Treatment with Levodopa/Carbidopa in MCT8 Deficiency

open access: yesMovement Disorders, EarlyView.
Abstract Background Allan‐Herndon‐Dudley syndrome (AHDS)/monocarboxylate transporter 8 (MCT8) deficiency is a rare X‐linked encephalopathy caused by SLC16A2 variants, impairing thyroid hormone (TH) transport into the brain. This leads to early central nervous system (CNS) TH deficiency, affecting brain maturation.
Fabio Bruschi   +12 more
wiley   +1 more source

Ultrasound Guidance to Augment Needle Electromyography Precision in the Complex Nerve Injury Setting

open access: yesMuscle &Nerve, EarlyView.
ABSTRACT The rise in popularity of nerve transfer surgery in individuals with peripheral nerve and spinal cord injuries has elevated the importance of the preoperative electrodiagnostic examination. Needle electromyography (EMG) provides peripheral nerve surgeons with precise information about donor and recipient muscle health, aiding in decisions ...
Nelson Saddler   +4 more
wiley   +1 more source

Relief of pain associated with spasticity in adult patients after treatment with onabotulinumtoxinA: Post hoc observational results from the ASPIRE study

open access: yesPM&R, EarlyView.
Abstract Background Pain is often observed in patients with spasticity, but little is known about the relationship between pain and spasticity and the effectiveness of treating pain with botulinum toxins in these patients. Objective To explore onabotulinumtoxinA (onabotA) use and pain relief in patients with spasticity with pain at baseline.
Jörg Wissel   +5 more
wiley   +1 more source

From Yeast to Therapeutics: Modeling Neurodegenerative Diseases in Saccharomyces cerevisiae

open access: yesYeast, EarlyView.
Yeast plasmids expressing human Aβ‐42, α‐syn, htt, and TDP‐43. Their fate includes an equilibrium between the endocytic pathway and aggregates that potentially disrupt endocytosis, vesicular transport, vacuolar autophagy, and mitochondrial activity. ABSTRACT Here, we review the use of Saccharomyces cerevisiae as a powerful model organism for studying ...
Jose Ribamar Ferreira‐Junior   +2 more
wiley   +1 more source

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