Results 81 to 90 of about 983,311 (294)

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Use of local muscle flaps to cover leg bone exposures

Revista do Colégio Brasileiro de Cirurgiões, 2014
Objective: To evaluate the use of the medial gastrocnemius muscle and/or soleus muscle flaps as surgical treatment of the leg bone exposure.Methods: We retrospectively analyzed the medical records of patients undergoing transposition of the medial ...
Francisco d'Avila, Diogo Franco, Bianca d'Avila, Marcio Arnaut Jr.   +3 more
doaj   +1 more source

Surgical debridement with muscle flap transposition and systemic teicoplanin therapy for infected hip arthroplasty

, 2010
The use of muscle flaps is now accepted as a method for coverage of infected wounds. To obtain complete eradication of infection following hip arthroplasty surgery is combined with antibiotic treatment.
VENDITTI, Mario, CECCARELLI, GIANCARLO, Giancarlo Ceccarelli, Vincenzo Vullo, VULLO, Vincenzo, TIERNO, FRANCESCA, D'ETTORRE, Gabriella, Mario Venditti, CARLESIMO, Bruno, F. Marchetti, Gabriella D'Ettorre, GIZZI, FRANCESCA, Francesco Marchetti, Francesca Tierno, Francesca Gizzi, FALCONE, MARCO, Marco Falcone, Bruno Carlesimo   +17 more
core   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source

Navigating the challenge: Successful management of inferior rectus hypoplasia and supernumerary lateral rectus

Indian Journal of Ophthalmology. Case Reports
Congenital isolated absence and hypoplasia of extraocular muscles is a rare condition that is frequently linked to craniofacial syndromes. The superior oblique muscle is most commonly noted to be absent, followed by the inferior rectus (IR) muscle.
Aparna Krishnan, Neelam Pawar, Ravindran Meenakshi, A Fathima   +3 more
doaj   +1 more source

TRANSPOSITION OF LATISSIMUS DORSI FOR PARALYSIS OF TRICEPS BRACHII

, 1967
1 . A case is described in which complete transposition of the latissimus dorsi muscle with its neurovascular pedicle was performed to compensate for complete paralysis of the triceps and partial paralysis of the posterior part of the deltoid muscle. 2.
S. J. Levy, G. T. du Toit
core   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Rates of Reoperation in Duane Retraction Syndrome

Ophthalmology Science
Purpose: To investigate the types of strabismus surgeries performed and the reoperation rate in patients with Duane retraction syndrome (DRS). Design: Retrospective cohort analysis. Participants: An insurance claims data set was used to identify patients
Han Woong Lim, MD, PhD, Bryce Hwang, MD, Cyril Archambault, MD, Scott R. Lambert, MD   +3 more
doaj   +1 more source

"Between Structure and Incident. A Sociological-Institutionalist Approach to the Riddle of Transposition Delays of European Food Safety Directives" [PDF]

, 2005
[From the Introduction]. The Dutch cannot expand their highway system as they like, because that gets them in conflict with European air quality standards; strictly enforcing the latter could also deal a death blow to the huge Dutch chicken industry ...
Ieva Gange, Waarden, Frans van., Frans Van Waarden, Gange, Ieva   +3 more
core