Results 91 to 100 of about 945,377 (287)

A Novel KCNA1 Variant in a Patient With Tremor and Autism Spectrum Disorder Causes Mixed LOF/GOF Defects of Kv1.1 Channels

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Variants in KCNA1, encoding the Kv1.1 potassium channel, cause neurological disorders including episodic ataxia and developmental and epileptic encephalopathy. We identified a novel KCNA1 variant (A401T) in a 16‐year‐old patient with autism spectrum disorder, borderline intellectual disability, and tremor, without episodic ataxia or epilepsy ...
Juan Darío Ortigoza‐Escobar, Laura Marti‐Sánchez, Loreto Martorell, Giorgia Dinoi, Antonio Vittorio Buono, Annamaria De Luca, Antonella Liantonio, Paola Imbrici   +7 more
wiley   +1 more source

miR-424-5p reduces ribosomal RNA and protein synthesis in muscle wasting [PDF]

, 2017
Background: A loss of muscle mass occurs as a consequence of a range of chronic and acute diseases as well as in older age. This wasting results from an imbalance of protein synthesis and degradation with a reduction in synthesis and resistance to ...
Polkey, Lee, J, Patel, H, Natanek, Sayer, A, Paul, R, lorenzo, Connolly, Wort, Cooper, C, Farre Garros, R, Griffiths, Bloch, Kemp, P   +13 more
core   +1 more source

Formoterol reduces muscle wasting in mice undergoing doxorubicin chemotherapy

Frontiers in Oncology
BackgroundEven though doxorubicin (DOX) chemotherapy promotes intense muscle wasting, this drug is still widely used in clinical practice due to its remarkable efficiency in managing cancer.
Edson Alves de Lima Junior, Alexandre Abilio de Souza Teixeira, Loreana Sanches Silveira, Queralt Jové, Natalia Álvarez Ladrón, Marcelo G. Pereira, Francisco Javier López-Soriano, Josep M. Argilés, Patrícia Chakur Brum, Silvia Busquets, José Cesar Rosa Neto   +10 more
doaj   +1 more source

PPARβ/δ regulates glucocorticoid- and sepsis-induced FOXO1 activation and muscle wasting.

PLoS ONE, 2013
FOXO1 is involved in glucocorticoid- and sepsis-induced muscle wasting, in part reflecting regulation of atrogin-1 and MuRF1. Mechanisms influencing FOXO1 expression in muscle wasting are poorly understood.
Estibaliz Castillero, Nima Alamdari, Zaira Aversa, Aniket Gurav, Per-Olof Hasselgren   +4 more
doaj   +1 more source

Characteristics and Outcomes of Male Participants in a Multicenter Longitudinal Australian Study Cohort

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to determine the differences in demographic, serologic, and clinical characteristics between male and female patients with systemic sclerosis (SSc) in an Australian cohort. Methods This was a retrospective observational study using data from the Australian Scleroderma Cohort Study.
Emily Lin, Dylan Hansen, Laura Ross, Gene‐Siew Ngian, Susanna Proudman, Gabor Major, Maryam Tabesh, Mandana Nikpour, Jennifer Walker, Lauren Host, Nava Ferdowsi, Alannah Quinlivan, Wendy Stevens, Joanne Sahhar, Diane Apostolopoulos   +14 more
wiley   +1 more source

Obesity Subtypes and Longitudinal Trajectories of Function Over Seven Years of Follow‐Up: Data From the Multicenter Osteoarthritis Study

Arthritis Care &Research, EarlyView.
Objective Obesity, defined by body mass index (BMI) ≥30 kg/m2, is a risk factor for functional limitations in people with knee osteoarthritis (OA). However, function varies among such individuals. Our objective was to evaluate the implications of obesity subtypes on longitudinal patterns of physical functioning in people with or at risk for knee OA ...
Kristine Godziuk, Sarah Tilley, Michael LaValley, Michael C. Nevitt, Cora E. Lewis, James C. Torner, Tuhina Neogi, for the Multicenter Osteoarthritis Study Group   +7 more
wiley   +1 more source

Anorectal Dysfunction in Systemic Sclerosis: Clinical Phenotypes and Functional Patterns

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to characterize specific physiologic defects in anorectal dysfunction in systemic sclerosis (SSc) using anorectal manometry (ARM), evaluate associations with gastrointestinal (GI) and extraintestinal clinical phenotypes, and explore potential serologic markers for risk stratification.
Timothy Kaniecki, Alireza Amindarolzarbi, Tsion Abdi, John Clarke, Michael Hughes, Ami A. Shah, Zsuzsanna H. McMahan   +6 more
wiley   +1 more source

Growth differentiation factor-15 is associated with muscle mass in chronic obstructive pulmonary disease and promotes muscle wasting in vivo. [PDF]

, 2015
BACKGROUND: Loss of muscle mass is a co-morbidity common to a range of chronic diseases including chronic obstructive pulmonary disease (COPD). Several systemic features of COPD including increased inflammatory signalling, oxidative stress, and hypoxia ...
Wells, C E, Natanek, SA, Lee, J, Amanda Natanek, Benjamin E. Garfield, Man, W, Dominic J. Wells, Hopkinson, NS, Mehul S. Patel, Anna V. Donaldson, Paul R. Kemp, Bloch, S, Garfield, BE, Baz, M, Wells, DJ, Polkey, MI, Baker, E H, Kemp, P R, Baker, EH, Garfield, B, Garfield, B E, Wells, D J, Lewis, A, Donaldson, AV, Kemp, PR, Donaldson, A V, Kemp, P, William D‐C Man, Patel, MS, Man, WD-C, Patel, M S, Wells, D, Polkey, M I, Manuel Baz, Claire E. Wells, Michael I. Polkey, Hopkinson, N S, Natanek, A, Nicholas S. Hopkinson, Wells, CE, Emma H. Baker, Amy Lewis, Jen Lee, Man, W D C, Susannah Bloch   +44 more
core   +1 more source

Increased fat accumulation may be associated with severe muscle wasting in critically ill patients: a prospective observational study

Scientific Reports
Obesity has been hypothesized to attenuate muscle wasting in critically ill patients due to increased ketogenesis. This study examined the associations between fat mass volume, ketone bodies, and muscle wasting in critically ill patients.
Yasutaka Koga, Motoki Fujita, Kayoko Harada, Masaru Shin, Ryo Ayata, Tomoaki Inoue, Kotaro Kaneda, Ryosuke Tsuruta   +7 more
doaj   +1 more source

Fabrication Routes for Ionic Conducting Fiber Strain Sensors

Advanced Engineering Materials, EarlyView.
Ionic conducting fiber strain sensors (ICFSs) offer compliant, textile‐integrable sensing. Thus far, the commercialization of ICFSs has been constrained by fiber fabrication routes. This review provides a fabrication‐centric analysis of ICFSs correlating processing strategies with material properties and scalability.
Leo John Kershaw, Zhanhong Yang, Anne Ladegaard Skov, Magdalena Skowyra   +3 more
wiley   +1 more source