Results 1 to 10 of about 64,866 (299)

Development and validation of a clinically applicable score to classify cachexia stages in advanced cancer patients

Journal of Cachexia, Sarcopenia and Muscle, 2018
Background Cachexia is a multifactorial syndrome that is highly prevalent in advanced cancer patients and leads to progressive functional impairments. The classification of cachexia stages is essential for diagnosing and treating cachexia. However, there
Zhou Ting, Bangyan Wang, Shiying Yu
exaly   +2 more sources

Tumor-derived MG53 aggravates gastrointestinal cancer cachexia related muscle atrophy by inhibiting the TLR4/PI3K/AKT/FOXO3a signaling pathway [PDF]

Frontiers in Oncology
BackgroundCancer cachexia is a multisystem syndrome characterized by progressive skeletal muscle atrophy, anorexia, and weight loss, imposing a substantial global health burden.
Yong-Fei Wang, Yong-Fei Wang, Yong-Fei Wang, Yuan-Yuan Xin, Si-Yuan Wang, Zi-Yi An, Dong-Yang Qi, Wen- Li, Wei-Lin Jin, Wen-Zhen Yuan, Wen-Zhen Yuan   +10 more
doaj   +2 more sources

Association Between Cachexia Defined by the Asian Working Group for Cachexia Criteria and One-Year Post-Discharge Mortality in Older Adults with Acute Decompensated Heart Failure [PDF]

Geriatrics
Background: Cachexia is a well-known clinically important condition in older adults with heart failure, but evidence regarding cachexia defined by the Asian Working Group for Cachexia (AWGC) criteria in those with acute decompensated heart failure (ADHF)
Daisuke Suzuki, Toshimi Sato, Yuichiro Sasamoto, Shun Monoe, Keita Kaneko, Shinichiro Morishita   +5 more
doaj   +2 more sources

Identification of circulating plasma ceramides as a potential sexually dimorphic biomarker of pancreatic cancer‐induced cachexia

JCSM Rapid Communications, 2022
Background Cancer patients who exhibit cachexia lose weight and have low treatment tolerance and poor outcomes compared with cancer patients without weight loss.
Jeffery M. Chakedis, Mary E. Dillhoff, Carl R. Schmidt, Priyani V. Rajasekera, David C. Evans, Terence M. Williams, Denis C. Guttridge, Erin E. Talbert   +7 more
doaj   +1 more source

Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice

Journal of Cachexia, Sarcopenia and Muscle, 2021
Background Disuse decreases muscle size and is predictive of mortality across multiple pathologies. Detriments to mitochondrial function are hypothesized to underlie disuse‐induced muscle atrophy.
Megan E. Rosa‐Caldwell, Seongkyun Lim, Wesley S. Haynie, Jacob L. Brown, David E. Lee, Kirsten R. Dunlap, Lisa T. Jansen, Tyrone A. Washington, Michael P. Wiggs, Nicholas P. Greene   +9 more
doaj   +1 more source

Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy

Journal of Cachexia, Sarcopenia and Muscle, 2021
Background Muscle atrophy is a common pathology associated with disuse, such as prolonged bed rest or spaceflight, and is associated with detrimental health outcomes.
Megan E. Rosa‐Caldwell, Seongkyun Lim, Wesley A. Haynie, Jacob L. Brown, John William Deaver, Francielly Morena Da Silva, Lisa T. Jansen, David E. Lee, Michael P. Wiggs, Tyrone A. Washington, Nicholas P. Greene   +10 more
doaj   +1 more source

Screening Assessment and Therapy Intervention of Cancer Cachexia in Adult Patients——Based on the Interpretation of Cancer Cachexia in Adult Patients: ESMO Clinical Practice Guidelines [PDF]

Zhongguo quanke yixue, 2023
Cancer cachexia is a cancer-related, multi-factorial, irreversible clinical syndrome characterized by progressive nutritional consumption, which greatly reduces the survival expectation and quality of life of cancer patient.
WANG Rui, WANG Xiaomei, PENG Guoqing, YU Huan, WANG Sihan, XIA Jin
doaj   +1 more source

Survival and biomarkers for cachexia in non‐small cell lung cancer receiving immune checkpoint inhibitors

Cancer Medicine, 2023
Background The presence of cachexia negatively impacts the prognosis of patients with cancer. However, the mechanisms behind the development of cachexia and its prognostic impact on immunotherapy efficacy are not fully understood.
Daiki Murata, Koichi Azuma, Norikazu Matsuo, Kenta Murotani, Goushi Matama, Akihiko Kawahara, Tetsuro Sasada, Takaaki Tokito, Tomoaki Hoshino   +8 more
doaj   +1 more source

Cachexia in Cancer Patients: Systematic Literature Review

Asian Journal of Oncology, 2020
Introduction Cachexia in cancer patients, especially in advanced stage, is recently known as an emerging problem. Cachexia occurs in about half of all patients with neoplastic disease.
Timotius I. Hariyanto, Andree Kurniawan
doaj   +1 more source

Early Decrease in Respiration and Uncoupling Event Independent of Cytochrome c Release in PC12 Cells Undergoing Apoptosis

International Journal of Cell Biology, 2012
Cytochrome c is a key molecule in mitochondria-mediated apoptosis. It also plays a pivotal role in cell respiration. The switch between these two functions occurs at the moment of its release from mitochondria.
Libera Berghella, Elisabetta Ferraro
doaj   +1 more source