Results 1 to 10 of about 50,388 (119)

Development and validation of a clinically applicable score to classify cachexia stages in advanced cancer patients

Journal of Cachexia, Sarcopenia and Muscle, 2018
Background Cachexia is a multifactorial syndrome that is highly prevalent in advanced cancer patients and leads to progressive functional impairments. The classification of cachexia stages is essential for diagnosing and treating cachexia. However, there
Zhou Ting, Bangyan Wang, Huiquan Liu
exaly   +2 more sources

Identification of circulating plasma ceramides as a potential sexually dimorphic biomarker of pancreatic cancer‐induced cachexia

JCSM Rapid Communications, 2022
Background Cancer patients who exhibit cachexia lose weight and have low treatment tolerance and poor outcomes compared with cancer patients without weight loss.
Jeffery M. Chakedis, Mary E. Dillhoff, Carl R. Schmidt, Priyani V. Rajasekera, David C. Evans, Terence M. Williams, Denis C. Guttridge, Erin E. Talbert   +7 more
doaj   +1 more source

Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice

Journal of Cachexia, Sarcopenia and Muscle, 2021
Background Disuse decreases muscle size and is predictive of mortality across multiple pathologies. Detriments to mitochondrial function are hypothesized to underlie disuse‐induced muscle atrophy.
Megan E. Rosa‐Caldwell, Seongkyun Lim, Wesley S. Haynie, Jacob L. Brown, David E. Lee, Kirsten R. Dunlap, Lisa T. Jansen, Tyrone A. Washington, Michael P. Wiggs, Nicholas P. Greene   +9 more
doaj   +1 more source

Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy

Journal of Cachexia, Sarcopenia and Muscle, 2021
Background Muscle atrophy is a common pathology associated with disuse, such as prolonged bed rest or spaceflight, and is associated with detrimental health outcomes.
Megan E. Rosa‐Caldwell, Seongkyun Lim, Wesley A. Haynie, Jacob L. Brown, John William Deaver, Francielly Morena Da Silva, Lisa T. Jansen, David E. Lee, Michael P. Wiggs, Tyrone A. Washington, Nicholas P. Greene   +10 more
doaj   +1 more source

Screening Assessment and Therapy Intervention of Cancer Cachexia in Adult Patients——Based on the Interpretation of Cancer Cachexia in Adult Patients: ESMO Clinical Practice Guidelines [PDF]

Zhongguo quanke yixue, 2023
Cancer cachexia is a cancer-related, multi-factorial, irreversible clinical syndrome characterized by progressive nutritional consumption, which greatly reduces the survival expectation and quality of life of cancer patient.
WANG Rui, WANG Xiaomei, PENG Guoqing, YU Huan, WANG Sihan, XIA Jin
doaj   +1 more source

Survival and biomarkers for cachexia in non‐small cell lung cancer receiving immune checkpoint inhibitors

Cancer Medicine, 2023
Background The presence of cachexia negatively impacts the prognosis of patients with cancer. However, the mechanisms behind the development of cachexia and its prognostic impact on immunotherapy efficacy are not fully understood.
Daiki Murata, Koichi Azuma, Norikazu Matsuo, Kenta Murotani, Goushi Matama, Akihiko Kawahara, Tetsuro Sasada, Takaaki Tokito, Tomoaki Hoshino   +8 more
doaj   +1 more source

Cachexia in Cancer Patients: Systematic Literature Review

Asian Journal of Oncology, 2020
Introduction Cachexia in cancer patients, especially in advanced stage, is recently known as an emerging problem. Cachexia occurs in about half of all patients with neoplastic disease.
Timotius I. Hariyanto, Andree Kurniawan
doaj   +1 more source

Comparative plasma proteomics in muscle atrophy during cancer‐cachexia and disuse: The search for atrokines

Physiological Reports, 2020
Skeletal muscle atrophy is common across a variety of pathologies. Underlying mechanisms of atrophy differ between pathologies, and in many conditions, circulating factors are tied to muscle atrophy.
Seongkyun Lim, Kirsten R. Dunlap, Megan E. Rosa‐Caldwell, Wesley S. Haynie, Lisa T. Jansen, Tyrone A. Washington, Nicholas P. Greene   +6 more
doaj   +1 more source

Cardiac Remodeling in Cancer-Induced Cachexia: Functional, Structural, and Metabolic Contributors

Cells, 2022
Cancer cachexia is a syndrome of progressive weight loss and muscle wasting occurring in many advanced cancer patients. Cachexia significantly impairs quality of life and increases mortality. Cardiac atrophy and dysfunction have been observed in patients
Michael P. Wiggs, Anna G. Beaudry, Michelle L. Law   +2 more
doaj   +1 more source

Prognostic effect of cachexia in patients with non‐small cell lung cancer receiving immune checkpoint inhibitors

Thoracic Cancer, 2023
Background The presence of cachexia in cancer patients negatively affects the quality of life and survival. However, the impact of cachexia on immunotherapy, such as PD‐1/L1 inhibitors, is not fully understood.
Norikazu Matsuo, Koichi Azuma, Kenta Murotani, Daiki Murata, Goushi Matama, Akihiko Kawahara, Takashi Kojima, Takaaki Tokito, Tomoaki Hoshino   +8 more
doaj   +1 more source