Results 21 to 30 of about 93,078 (303)
Eicosapentaenoic acid and oxypurinol in the treatment of muscle wasting in a mouse model of cancer cachexia [PDF]
, 2012 Cancer cachexia is a wasting condition, driven by systemic inflammation and oxidative stress. This study investigated eicosapentaenoic acid (EPA) in combination with oxypurinol as a treatment in a mouse model of cancer cachexia. Mice with cancer cachexia
Hinch, Edward +4 more
core +2 more sources
Journal of Oral and Maxillofacial Pathology, 2011 Cancer cachexia is a wasting syndrome characterized by weight loss, anorexia, asthenia and anemia. The pathogenicity of this syndrome is multifactorial, due to a complex interaction of tumor and host factors. The signs and symptoms of cachexia are considered as the prognostic parameters in cancer patients.
Dhanapal, Raghu +2 more
openaire +3 more sources
Journal of Cachexia, Sarcopenia and Muscle, 2018 Background Cancer‐associated wasting, termed cancer cachexia, has a profound effect on the morbidity and mortality of cancer patients but remains difficult to recognize and diagnose.
Erin E. Talbert +15 more
doaj +1 more source
Human cachexia induces changes in mitochondria, autophagy and apoptosis in the skeletal muscle [PDF]
, 2019 Cachexia is a wasting syndrome characterized by the continuous loss of skeletal muscle mass due to imbalance between protein synthesis and degradation, which is related with poor prognosis and compromised quality of life.
Alcantara, P. S. +9 more
core +1 more source
Mediators and clinical treatment for cancer cachexia: a systematic review
JCSM Rapid Communications, 2021 Background Cachexia, a complex multi‐organ syndrome, shortens survival time of patients, particularly those with cancer. Many studies and clinical trials have been carried out to identify cachexia‐inducing factors and potential treatments for cancer ...
Zhipeng Cao +3 more
doaj +1 more source
Cardiac Remodeling in Cancer-Induced Cachexia: Functional, Structural, and Metabolic Contributors
Cells, 2022 Cancer cachexia is a syndrome of progressive weight loss and muscle wasting occurring in many advanced cancer patients. Cachexia significantly impairs quality of life and increases mortality. Cardiac atrophy and dysfunction have been observed in patients
Michael P. Wiggs +2 more
doaj +1 more source
Pharmacological strategies in lung cancer-induced cachexia: effects on muscle proteolysis, autophagy, structure, and weakness [PDF]
, 2014 Muscle wasting and cachexia are important systemic manifestations of highly prevalent conditions including cancer. Inflammation, oxidative stress, autophagy, ubiquitin-proteasome system, nuclear factor (NF)-kB, and mitogen activated protein kinases (MAPK)
Bal, Elisa Dora +7 more
core +1 more source
Annals of Medicine, 2004 Chronic heart failure (CHF) remains an important and increasing public health care problem. It is a complex syndrome affecting many body systems. Body wasting (i.e., cardiac cachexia) has long been recognised as a serious complication of CHF. Cardiac cachexia is associated with poor prognosis, independently of functional disease severity, age, and ...
Stefan D, Anker +2 more
openaire +2 more sources
Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk [PDF]
, 2019 BACKGROUND: Muscle wasting from chronic kidney disease (CKD) or from defective insulin signalling results in morbidity and, ultimately, mortality. We have identified an endogenous mediator of insulin resistance, signal regulatory protein alpha (SIRPα ...
Dong, Jiangling +7 more
core +2 more sources
Myocardial Dysfunction in an Animal Model of Cancer Cachexia [PDF]
, 2011 Aims Fatigue is a common occurrence in cancer patients regardless of tumor type or anti-tumor therapies and is an especially problematic symptom in persons with incurable tumor disease.
Crawford, Danielle +7 more
core +2 more sources