Results 11 to 20 of about 50,600 (264)
Mediators of Inflammation, 2015 Cachexia is a complex wasting syndrome associated with a marked detrimental effect upon life quality and survival in patients with cancer, chronic obstructive pulmonary disease (COPD), chronic heart failure, AIDS, and chronic kidney disease, among other conditions. Its prevalence is of around 5 to 15% in cardiac patients at end stage, rising up to 30%,
Seelaender M. +5 more
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Annals of Medicine, 2004 Chronic heart failure (CHF) remains an important and increasing public health care problem. It is a complex syndrome affecting many body systems. Body wasting (i.e., cardiac cachexia) has long been recognised as a serious complication of CHF. Cardiac cachexia is associated with poor prognosis, independently of functional disease severity, age, and ...
Stefan D, Anker +2 more
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International Journal of Cell Biology, 2012 Cytochrome c is a key molecule in mitochondria-mediated apoptosis. It also plays a pivotal role in cell respiration. The switch between these two functions occurs at the moment of its release from mitochondria.
Libera Berghella, Elisabetta Ferraro
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Thoracic Cancer, 2023 Background The presence of cachexia in cancer patients negatively affects the quality of life and survival. However, the impact of cachexia on immunotherapy, such as PD‐1/L1 inhibitors, is not fully understood.
Norikazu Matsuo +8 more
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Journal of Cachexia, Sarcopenia and Muscle, 2018 Background Cancer‐associated wasting, termed cancer cachexia, has a profound effect on the morbidity and mortality of cancer patients but remains difficult to recognize and diagnose.
Erin E. Talbert +15 more
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Cardiac Remodeling in Cancer-Induced Cachexia: Functional, Structural, and Metabolic Contributors
Cells, 2022 Cancer cachexia is a syndrome of progressive weight loss and muscle wasting occurring in many advanced cancer patients. Cachexia significantly impairs quality of life and increases mortality. Cardiac atrophy and dysfunction have been observed in patients
Michael P. Wiggs +2 more
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Mediators and clinical treatment for cancer cachexia: a systematic review
JCSM Rapid Communications, 2021 Background Cachexia, a complex multi‐organ syndrome, shortens survival time of patients, particularly those with cancer. Many studies and clinical trials have been carried out to identify cachexia‐inducing factors and potential treatments for cancer ...
Zhipeng Cao +3 more
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Physiological Reports, 2020 Skeletal muscle atrophy is common across a variety of pathologies. Underlying mechanisms of atrophy differ between pathologies, and in many conditions, circulating factors are tied to muscle atrophy.
Seongkyun Lim +6 more
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Journal of Oral and Maxillofacial Pathology, 2011 Cancer cachexia is a wasting syndrome characterized by weight loss, anorexia, asthenia and anemia. The pathogenicity of this syndrome is multifactorial, due to a complex interaction of tumor and host factors. The signs and symptoms of cachexia are considered as the prognostic parameters in cancer patients.
Dhanapal, Raghu +2 more
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Targeting cancer cachexia: Molecular mechanisms and clinical study
MedComm, 2022 Cancer cachexia is a complex systemic catabolism syndrome characterized by muscle wasting. It affects multiple distant organs and their crosstalk with cancer constitute cancer cachexia environment. During the occurrence and progression of cancer cachexia,
Yong‐Fei Wang +3 more
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