Results 31 to 40 of about 64,866 (299)
European Heart Journal Supplements, 2019 AbstractCachexia is a multifactorial disease characterized by a pathologic shift of metabolism towards a more catabolic state. It frequently occurs in patients with chronic diseases such as chronic heart failure and is especially common in the elderly. In patients at risk, cardiac cachexia is found in about 10% of heart failure patients.
Lena, Alessia +2 more
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Nutritional, pharmacological and hormonal manipulation of muscle metabolism [PDF]
, 2010 PhDSarcopenia and cachexia occur when there is a deficit between the rates of muscle protein synthesis and breakdown, such that a negative balance exists.
Wilkes, Emilie Anne
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Journal of Cachexia, Sarcopenia and Muscle, 2010 Ghrelin, a natural ligand for the growth hormone (GH)‐secretagogue receptor, is primarily produced in the stomach. Administration of ghrelin stimulates food intake and GH secretion in both animals and humans. Ghrelin is the only circulating hormone known to stimulate appetite in humans.
Akamizu, Takashi, Kangawa, Kenji
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Targeting cancer cachexia: Molecular mechanisms and clinical study
MedComm, 2022 Cancer cachexia is a complex systemic catabolism syndrome characterized by muscle wasting. It affects multiple distant organs and their crosstalk with cancer constitute cancer cachexia environment. During the occurrence and progression of cancer cachexia,
Yong‐Fei Wang +3 more
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Journal of Oral and Maxillofacial Pathology, 2011 Cancer cachexia is a wasting syndrome characterized by weight loss, anorexia, asthenia and anemia. The pathogenicity of this syndrome is multifactorial, due to a complex interaction of tumor and host factors. The signs and symptoms of cachexia are considered as the prognostic parameters in cancer patients.
Dhanapal, Raghu +2 more
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British Journal of Cancer, 1991 Cachexia is a common problem in the clinical management of cancer patients, particularly those with solid tumors. Cachexia is most obviously manifested as weight loss with massive depletion of both adipose tissue and muscle mass, and death is probably due to loss of lean body tissue.
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Appetite and dietary intake endpoints in cancer cachexia clinical trials: Systematic Review 2 of the cachexia endpoints series. [PDF]
There is no consensus on the optimal endpoint(s) in cancer cachexia trials. Endpoint variation is an obstacle when comparing interventions and their clinical value.
Hjermstad, MJ +24 more
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Applied Biological Chemistry, 2019 Cachexia is a wasting syndrome associated with high mortality in cancer patients through inducing the failure of normal metabolism and reducing the efficacy of cancer treatment. Thus, it is critically important to diagnose cancer cachexia early.
Jae Eun Ju +7 more
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EMBO Molecular MedicineCancer cachexia is a debilitating syndrome characterized by the progressive loss of skeletal muscle mass with or without fat loss. Recent studies have implicated dysregulation of the endoplasmic reticulum (ER) stress-induced unfolded protein response ...
Aniket S Joshi +5 more
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Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono +7 more
wiley +1 more source