Results 51 to 60 of about 64,866 (299)

Body weight and composition endpoints in cancer cachexia clinical trials: Systematic Review 4 of the cachexia endpoints series. [PDF]

Significant variation exists in the outcomes used in cancer cachexia trials, including measures of body composition, which are often selected as primary or secondary endpoints.
McMillan, DC, Hjermstad, MJ, Maddocks, M, Bye, A, Arends, J, Sayers, J, Sousa, MS, Simpson, MR, Skipworth, RJE, Ottestad, IO, Balstad, TR, Greil, C, McDonald, J, Cancer Cachexia Endpoints Working Group,, Brown, LR, Vagnildhaug, OM, Laird, BJA, Solheim, TS, Baracos, VE, Dolan, RD, Jakobsen, G, Phillips, I, Dajani, O, Fallon, MT, Yule, MS   +24 more
core   +1 more source

Signaling networks governing skeletal muscle growth, atrophy, and cachexia

Skeletal Muscle
Maintaining skeletal muscle mass and strength is essential for healthy aging and overall longevity. Muscle mass is governed by a complex network of signaling pathways that coordinate proteostasis and regulate the expression of anabolic and catabolic ...
Aniket S Joshi, Meiricris Tomaz da Silva, Savita Kumar, Ashok Kumar   +3 more
doaj   +1 more source

Associations of low hand grip strength with 1 year mortality of cancer cachexia: a multicentre observational study

Journal of Cachexia, Sarcopenia and Muscle, 2021
Backgrounds Hand grip strength (HGS) is one of diagnose criteria factors of sarcopenia and is associated with the survival of patients with cancer. However, few studies have addressed the association of HGS and 1 year mortality of patients with cancer ...
Mengmeng Song, Qi Zhang, Meng Tang, Xi Zhang, Guotian Ruan, Xiaowei Zhang, Kangping Zhang, Yizhong Ge, Ming Yang, Qinqin Li, Xiangrui Li, Xiaoyue Liu, Wei Li, Minghua Cong, Kunhua Wang, Chunhua Song, Hanping Shi   +16 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Sex specificity of pancreatic cancer cachexia phenotypes, mechanisms, and treatment in mice and humans: role of Activin

, 2022
BACKGROUND: Cachexia is frequent, deadly, and untreatable for patients with pancreatic ductal adenocarcinoma (PDAC). The reproductive hormone and cytokine Activin is a mediator of PDAC cachexia, and Activin receptor targeting was clinically tested for ...
Safi Shahda, Narasimhan, Ashok, Liu, Sheng, Koniaris, Leonidas G., Andrew R. Young, Xiaoling Zhong, Shahda, Safi, Ashok Narasimhan, Sheng Liu, Leonidas G. Koniaris, Liu, Yunlong, Jun Wan, Wan, Jun, Young, Andrew R., Yunlong Liu, Teresa A. Zimmers, Zimmers, Teresa A., Zhong, Xiaoling, Silverman, Libbie M., Libbie M. Silverman   +19 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Tumour-derived transforming growth factor-beta signalling contributes to fibrosis in patients with cancer cachexia

, 2020
Background Cachexia is a paraneoplastic syndrome related with poor prognosis. The tumour micro-environment contributes to systemic inflammation and increased oxidative stress as well as to fibrosis.
Tokeshi, Flavio, Seelaender, Marilia, Laviano, Alessandro, Zorn, Telma M. T., Otoch, Jose P., Pinto, Nelson, I., Alcantara, Paulo, Lima, Joanna D. C. C., Alves, Michele J., de Castro, Gabriela, Felipe-Silva, Aloisio S., Morais, Mychel Raony P. T., Figueredo, Raquel G., Cabral, Fernanda J., de Matos-Neto, Emidio M., Simoes, Estefania, Ferro, Emer S.   +16 more
core   +1 more source

PROTEOLYSIS AND AUTOPHAGY IN THE VASTUS LATERALIS OF PATIENTS WITH BRONCHIECTASIS-ASSOCIATED SARCOPENIA: ROLE IN TRAINING PROGRAMS

Open Respiratory Archives
Introduction: Muscle dysfunction or sarcopenia is a systemic manifestation of chronic respiratory diseases such as COPD and non-cystic fibrosis (non-CF) bronchiectasis.
Cinta Cumplí Gargallo, Adriana Núñez-Robainas, Mariela Alvarado-Miranda, Marina Sáinz, Esther Barreiro   +4 more
doaj   +1 more source

Respiratory and Peripheral Muscle Weakness and Body Composition Abnormalities in Non-Cystic Fibrosis Bronchiectasis Patients: Gender Differences

Biomedicines, 2022
As demonstrated in COPD, bronchiectasis patients may experience respiratory and peripheral muscle dysfunction. We hypothesized that respiratory and peripheral (upper and lower limbs) muscle function and nutritional status may be more significantly ...
Xuejie Wang, Ana Balaña-Corberó, Juana Martínez-Llorens, Liyun Qin, Yingchen Xia, Jianhua Zha, José María Maiques, Esther Barreiro   +7 more
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source