The role of extracellular vesicles in skeletal muscle wasting
Journal of Cachexia, Sarcopenia and Muscle, 2023 Skeletal muscle wasting is a complicated metabolic syndrome accompanied by multiple diseases ranging from cancer to metabolic disorders and infectious conditions. The loss of muscle mass significantly impairs muscle function, resulting in poor quality of
Xiaohui Zhang, Yanxia Zhao, Wei Yan
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Role of mitochondrial dysfunction in muscle wasting in cancer cachexia: a narrative review [PDF]
Journal of Translational MedicineBackground Cancer cachexia is a complex syndrome characterized by significant muscle loss, weight loss, and impaired physical function. One of the core causes of excessive muscle wasting in cancer cachexia patients is mitochondrial dysfunction, which ...
Xiaoyu Su +7 more
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Protective association of renin‐angiotensin system inhibitor use with skeletal muscle wasting in diabetic heart failure [PDF]
Journal of Diabetes InvestigationAims Muscle wasting is common in heart failure (HF) patients, particularly those with diabetes mellitus (DM). Renin‐angiotensin system inhibitors (RASI) may have muscle‐protective effects, but their association with muscle wasting in diabetic HF patients
Hidemichi Kouzu +10 more
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Transcriptomic insights into aerobic exercise-mediated attenuation of high-fat diet–induced muscle wasting [PDF]
Frontiers in PhysiologyChronic consumption of high-fat diets (HFDs) induces obesity and metabolic dysfunction and is accompanied by progressive skeletal muscle wasting. Although aerobic exercise is generally considered less effective for maintaining muscle mass, accumulating ...
Weihao Hong +6 more
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Targeting Dio3 to enhance mitophagy and ameliorate skeletal muscle wasting in sepsis [PDF]
Redox BiologyRecent studies highlight the role of skeletal muscle wasting in the sepsis-associated long-term mortality. Despite clinical recommendations for increased protein intake to counteract muscle wasting, the outcomes have been suboptimal, suggesting that ...
Gang Wang +12 more
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Sepsis-associated skeletal muscle wasting is ameliorated by pharmacological inhibition of the STAT3 signaling pathway in mice [PDF]
Scientific ReportsPatients with sepsis frequently experience skeletal muscle atrophy and weakness, which adversely affect survival and hinder functional recovery. Currently, no approved treatments are available for sepsis-associated muscle wasting.
Yuko Ono +8 more
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Vitamin D binding protein induces skeletal muscle atrophy and contributes to cancer-associated muscle wasting independently of vitamin D status in preclinical models [PDF]
Nature CommunicationsThe maintenance of skeletal muscle is of pivotal importance, as its loss is often associated with progressive pathologies, generally worsening the prognosis.
Tommaso Raiteri +14 more
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Cathepsin L as a dual-target to mitigate muscle wasting while enhancing anti-tumor efficacy of anti-PD-L1 [PDF]
Nature CommunicationsImmune checkpoint inhibitors (ICIs) have revolutionized cancer therapy; however, their use is frequently associated with immune-related adverse events (irAEs).
Se-Young Park +14 more
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Beneficial Effects of Resveratrol in Mouse Gastrocnemius: A Hint to Muscle Phenotype and Proteolysis
Cells, 2021 We hypothesized that the phenolic compound resveratrol mitigates muscle protein degradation and loss and improves muscle fiber cross-sectional area (CSA) in gastrocnemius of mice exposed to unloading (7dI).
Laura Mañas-García +5 more
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Biomedicines, 2022 As demonstrated in COPD, bronchiectasis patients may experience respiratory and peripheral muscle dysfunction. We hypothesized that respiratory and peripheral (upper and lower limbs) muscle function and nutritional status may be more significantly ...
Xuejie Wang +7 more
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