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The role of extracellular vesicles in skeletal muscle wasting

Journal of Cachexia, Sarcopenia and Muscle, 2023
Skeletal muscle wasting is a complicated metabolic syndrome accompanied by multiple diseases ranging from cancer to metabolic disorders and infectious conditions. The loss of muscle mass significantly impairs muscle function, resulting in poor quality of
Xiaohui Zhang, Yanxia Zhao, Wei Yan
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MicroRNAs in muscle wasting [PDF]

Journal of Cachexia, Sarcopenia and Muscle, 2018
Skeletal muscle makes up approximately 40% of the total body mass; it is essential in providing structural support, to regulate motion and as an energy store, thereby playing a major role in the overall metabolism. Skeletal muscle retains a high plasticity in order to respond to various stimuli, which subsequently lead to changes in gene transcription ...
Tsuyoshi Suzuki, Jochen Springer
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Protective association of renin‐angiotensin system inhibitor use with skeletal muscle wasting in diabetic heart failure [PDF]

Journal of Diabetes Investigation
Aims Muscle wasting is common in heart failure (HF) patients, particularly those with diabetes mellitus (DM). Renin‐angiotensin system inhibitors (RASI) may have muscle‐protective effects, but their association with muscle wasting in diabetic HF patients
Hidemichi Kouzu, Toshiyuki Yano, Satoshi Katano, Wataru Kawaharata, Ryo Numazawa, Ryohei Nagaoka, Hiroki Aida, Katsuhiko Ohori, Takefumi Fujito, Nobutaka Nagano, Masato Furuhashi   +10 more
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Role of mitochondrial dysfunction in muscle wasting in cancer cachexia: a narrative review [PDF]

Journal of Translational Medicine
Background Cancer cachexia is a complex syndrome characterized by significant muscle loss, weight loss, and impaired physical function. One of the core causes of excessive muscle wasting in cancer cachexia patients is mitochondrial dysfunction, which ...
Xiaoyu Su, Sutong Wang, Yiwei Qu, Yong Wang, Zhihan Tian, Xingliang Chao, Ziyuan Li, Dufang Ma   +7 more
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Transcriptomic insights into aerobic exercise-mediated attenuation of high-fat diet–induced muscle wasting [PDF]

Frontiers in Physiology
Chronic consumption of high-fat diets (HFDs) induces obesity and metabolic dysfunction and is accompanied by progressive skeletal muscle wasting. Although aerobic exercise is generally considered less effective for maintaining muscle mass, accumulating ...
Weihao Hong, Weihao Hong, Jianrong Zheng, Yisheng Luan, Haibin Yu, Yueyun Xu, Bing Zhang   +6 more
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Chemotherapy-induced muscle wasting: an update

European Journal of Translational Myology, 2018
The majority of cancers are associated to cachexia, a severe form of weight loss mostly accounted for by skeletal muscle wasting. Cancer patients are often treated with chemotherapy, whose side effects are at times neglected or underestimated ...
Dario Coletti
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Targeting Dio3 to enhance mitophagy and ameliorate skeletal muscle wasting in sepsis [PDF]

Redox Biology
Recent studies highlight the role of skeletal muscle wasting in the sepsis-associated long-term mortality. Despite clinical recommendations for increased protein intake to counteract muscle wasting, the outcomes have been suboptimal, suggesting that ...
Gang Wang, Ming Chen, Yuheng Zhang, Dacheng Wang, Tao Gao, Jianfeng Duan, Huimin Lu, Minhua Cheng, Yun Xu, Xiaoyao Li, Yan Wang, Ke Cao, Wenkui Yu   +12 more
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Sepsis-associated skeletal muscle wasting is ameliorated by pharmacological inhibition of the STAT3 signaling pathway in mice [PDF]

Scientific Reports
Patients with sepsis frequently experience skeletal muscle atrophy and weakness, which adversely affect survival and hinder functional recovery. Currently, no approved treatments are available for sepsis-associated muscle wasting.
Yuko Ono, Masafumi Saito, Ikumi Yoshihara, Yutaka Kondo, Kazuho Sakamoto, Jun Sugiyama, Nobuto Nakanishi, Shigeaki Inoue, Joji Kotani   +8 more
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Cathepsin L as a dual-target to mitigate muscle wasting while enhancing anti-tumor efficacy of anti-PD-L1 [PDF]

Nature Communications
Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy; however, their use is frequently associated with immune-related adverse events (irAEs).
Se-Young Park, Kyuwon Son, Jiwoo Kim, Kyeongah Kim, Sungmin Joo, Bomi Kim, Myunggyo Lee, Wankyu Kim, Won-Jung Jung, Byung Kwan Choi, Nakyung Jeon, Won-Yoon Chung, Yinling Hu, Haeseung Lee, Na-Young Song   +14 more
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Beneficial Effects of Resveratrol in Mouse Gastrocnemius: A Hint to Muscle Phenotype and Proteolysis

Cells, 2021
We hypothesized that the phenolic compound resveratrol mitigates muscle protein degradation and loss and improves muscle fiber cross-sectional area (CSA) in gastrocnemius of mice exposed to unloading (7dI).
Laura Mañas-García, Charlotte Denhard, Javier Mateu, Xavier Duran, Joaquim Gea, Esther Barreiro   +5 more
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